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Protein PLXNB1 PDB 2JPH.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
External IDs MGI: 2154238 HomoloGene: 130508 GeneCards: PLXNB1
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PLXNB1
Genomic location for PLXNB1
Band 3p21.31 Start 48,403,854 bp[1]
End 48,430,051 bp[1]
RNA expression pattern
PBB GE PLXNB1 215668 s at fs.png

PBB GE PLXNB1 215807 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 48.4 – 48.43 Mb Chr 3: 109.1 – 109.12 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.[5][6][7]


Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.[8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.[9]


PLXNB1 has been shown to interact with ARHGEF12,[10] Rnd1[11] and ARHGEF11.[10][11][12][13]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164050 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053646 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111Freely accessible. PMID 8570614. 
  6. ^ Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A. 97 (23): 12457–62. doi:10.1073/pnas.220421797. PMC 18785Freely accessible. PMID 11035813. 
  7. ^ "Entrez Gene: PLXNB1 plexin B1". 
  8. ^ Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Letters. 529 (2-3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594. 
  9. ^ Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway". Molecular and Cellular Biology. 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270Freely accessible. PMID 16055703. 
  10. ^ a b Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504. 
  11. ^ a b Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235. 
  12. ^ Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458. 
  13. ^ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. 

Further reading[edit]