Pyruvate dehydrogenase (cytochrome)
|pyruvate dehydrogenase (cytochrome)|
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- pyruvate + ferricytochrome b1 + H2O acetate + CO2 + ferrocytochrome b1
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is pyruvate:ferricytochrome-b1 oxidoreductase. Other names in common use include pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) dehydrogenase, pyruvate:ubiquinone-8-oxidoreductase, and pyruvate oxidase (ambiguous). This enzyme participates in pyruvate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.
- Williams FR; Hager LP (1961). "A crystalline flavin pyruvate oxidase". J. Biol. Chem. 236: PC36–PC37.
- Koland JG, Gennis RB (1982). "Identification of an active site cysteine residue in Escherichia coli pyruvate oxidase". J. Biol. Chem. 257 (11): 6023–7. PMID 7042705.