Pyruvate dehydrogenase (cytochrome)

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pyruvate dehydrogenase (cytochrome)
EC no.
CAS no.9079-84-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a pyruvate dehydrogenase (cytochrome) (EC is an enzyme that catalyzes the chemical reaction

pyruvate + ferricytochrome b1 + H2O acetate + CO2 + ferrocytochrome b1

The 3 substrates of this enzyme are pyruvate, ferricytochrome b1, and H2O, whereas its 3 products are acetate, CO2, and ferrocytochrome b1.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is pyruvate:ferricytochrome-b1 oxidoreductase. Other names in common use include pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) dehydrogenase, pyruvate:ubiquinone-8-oxidoreductase, and pyruvate oxidase (ambiguous). This enzyme participates in pyruvate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.


  • Williams FR; Hager LP (1961). "A crystalline flavin pyruvate oxidase". J. Biol. Chem. 236: PC36–PC37.
  • Koland JG, Gennis RB (1982). "Identification of an active site cysteine residue in Escherichia coli pyruvate oxidase". J. Biol. Chem. 257 (11): 6023–7. PMID 7042705.