REC8

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REC8 meiotic recombination protein
Identifiers
Symbols REC8 ; HR21spB; REC8L1; Rec8p
External IDs OMIM608193 MGI1929645 HomoloGene3768 GeneCards: REC8 Gene
RNA expression pattern
PBB GE REC8L1 218599 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9985 56739
Ensembl ENSG00000100918 ENSMUSG00000002324
UniProt O95072 Q8C5S7
RefSeq (mRNA) NM_001048205 NM_020002
RefSeq (protein) NP_001041670 NP_064386
Location (UCSC) Chr 14:
24.17 – 24.18 Mb
Chr 14:
55.62 – 55.63 Mb
PubMed search [1] [2]

Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.[1][2][3][4]

Function[edit]

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.[4]

Interactions[edit]

REC8 has been shown to interact with SMC3.[3]

References[edit]

  1. ^ Parisi S, McKay MJ, Molnar M, Thompson MA, van der Spek PJ, van Drunen-Schoenmaker E et al. (May 1999). "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans". Molecular and Cellular Biology 19 (5): 3515–28. PMC 84144. PMID 10207075. 
  2. ^ Xu H, Beasley MD, Warren WD, van der Horst GT, McKay MJ (Jun 2005). "Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis". Developmental Cell 8 (6): 949–61. doi:10.1016/j.devcel.2005.03.018. PMID 15935783. 
  3. ^ a b Lee J, Iwai T, Yokota T, Yamashita M (Jul 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". Journal of Cell Science 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374. 
  4. ^ a b "Entrez Gene: REC8L1 REC8-like 1 (yeast)". 

Further reading[edit]