Nucleus reuniens

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Nucleus reuniens
Nucleus Reuniens.svg
Latin Nucleus reuniens
NeuroLex ID Reuniens nucleus
TA A14.1.08.632
FMA 62153
Anatomical terms of neuroanatomy

The nucleus reuniens is a component of the thalamic midline nuclear group.[1] In the human brain, it is located in the interthalamic adhesion (massa intermedia).[2]

The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures.[3] It sends projections to the medial prefrontal cortex, the hippocampus, and the entorhinal cortex,[4][5] although there exist sparse connections to many of the afferent structures as well.[6]

The prefrontal cortical-hippocampal connection allows it to regulate neural traffic between them with changes in attentiveness,[7] as well as contribute to associative learning,[8] spatial route planning,[9] resilience to stress[10] and memory generalization.[11]


  1. ^ Griffin, Amy L. (2015-01-01). "Role of the thalamic nucleus reuniens in mediating interactions between the hippocampus and medial prefrontal cortex during spatial working memory". Frontiers in Systems Neuroscience. 9. ISSN 1662-5137. PMC 4354269Freely accessible. PMID 25805977. doi:10.3389/fnsys.2015.00029. 
  2. ^ Carpenter, Malcolm; Sutin, Jerome (1983). Human Neuroanatomy. Baltimore: Williams & Wilkins. pp. 504–510. ISBN 0-683-01461-7. 
  3. ^ McKenna, J. T.; Vertes, R. P. (2004). "Afferent projections to nucleus reuniens of the thalamus". The Journal of Comparative Neurology. 480 (2): 115–142. PMID 15514932. doi:10.1002/cne.20342. 
  4. ^ Wouterlood, F. G.; Saldana, E.; Witter, M. P. (1990). "Projection from the nucleus reuniens thalami to the hippocampal region: Light and electron microscopic tracing study in the rat with the anterograde tracerPhaseolus vulgaris-leucoagglutinin". The Journal of Comparative Neurology. 296 (2): 179–203. PMID 2358531. doi:10.1002/cne.902960202. 
  5. ^ Vertes, R. P. (2006). "Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat". Neuroscience. 142 (1): 1–20. PMID 16887277. doi:10.1016/j.neuroscience.2006.06.027. 
  6. ^ Herkenham, M. (1978). "The connections of the nucleus reuniens thalami: Evidence for a direct thalamo-hippocampal pathway in the rat". The Journal of Comparative Neurology. 177 (4): 589–610. PMID 624792. doi:10.1002/cne.901770405. 
  7. ^ Vertes, R. P.; Hoover, W. B.; Szigeti-Buck, K.; Leranth, C. (2007). "Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus". Brain Research Bulletin. 71 (6): 601–609. PMID 17292803. doi:10.1016/j.brainresbull.2006.12.002. 
  8. ^ Eleore, L.; López-Ramos, J. C.; Guerra-Narbona, R.; Delgado-García, J. M. (2011). Izquierdo, Ivan, ed. "Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning". PLoS ONE. 6 (8): e23538. PMC 3156136Freely accessible. PMID 21858159. doi:10.1371/journal.pone.0023538. 
  9. ^ Ito, H. T.; Zhang, S. J.; Witter, M. P.; Moser, E. I.; Moser, M. B. (2015). "A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation". Nature. 522 (7554): 50–5. PMID 26017312. doi:10.1038/nature14396. 
  10. ^ Kafetzopoulos, V.; Kokras, N.; Sotiropoulos, I.; Oliveira, J. F.; Leite-Almeida, H.; Vasalou, A.; Sardinha, V. M.; Papadopoulou-Daifoti, Z.; Almeida, O. F. X. (2017-04-11). "The nucleus reuniens: a key node in the neurocircuitry of stress and depression". Molecular Psychiatry. ISSN 1476-5578. PMID 28397837. doi:10.1038/mp.2017.55. 
  11. ^ Xu, W.; Sudhof, T. C. (14 March 2013). "A Neural Circuit for Memory Specificity and Generalization". Science. 339 (6125): 1290–1295. PMC 3651700Freely accessible. PMID 23493706. doi:10.1126/science.1229534.