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Aliases SCG5, 7B2, P7B2, SGNE1, SgV, secretogranin V
External IDs MGI: 98289 HomoloGene: 37722 GeneCards: SCG5
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SCG5
Genomic location for SCG5
Band 15q13.3 Start 32,641,676 bp[1]
End 32,697,098 bp[1]
RNA expression pattern
PBB GE SCG5 203889 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 32.64 – 32.7 Mb Chr 2: 113.78 – 113.83 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[5][6][7] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein and is required for the production of an active PC2 enzyme.[8][9] It is an intrinsically disordered protein that may also function as a chaperone for other proteins in addition to proPC2.


  1. ^ a b c ENSG00000166922, ENSG00000281931 GRCh38: Ensembl release 89: ENSG00000277614, ENSG00000166922, ENSG00000281931 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023236 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lloyd RV, Jin L (May 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol. 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254. 
  6. ^ Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med. 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671. 
  7. ^ Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Lett. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253. 
  8. ^ "Entrez Gene: SCG5 secretogranin V (7B2 protein)". 
  9. ^ Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". Biochem. J. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959Freely accessible. PMID 11439082. 

Further reading[edit]