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snRNP70

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Template:PBB snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[1] that in humans is encoded by the SNRNP70 gene.[2][3] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming part of the spliceosome.

Interactions

snRNP70 has been shown to interact with ASF/SF2,[4][5] SRPK1,[6][7] and ZRANB2.[8]

Role in autoimmunity

Antibodies towards snRNP70 are associated with mixed connective tissue disease.[9]

Template:PBB Summary

References

  1. ^ Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Res. 15 (24): 10373–91. doi:10.1093/nar/15.24.10373. PMC 339950. PMID 2447561.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)".
  3. ^ Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (October 1990). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics. 8 (2): 371–9. doi:10.1016/0888-7543(90)90295-6. PMID 2147422.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243.
  5. ^ Cao W, Garcia-Blanco MA (August 1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". J. Biol. Chem. 273 (32): 20629–35. doi:10.1074/jbc.273.32.20629. PMID 9685421.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (February 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Kamachi M, Le TM, Kim SJ, Geiger ME, Anderson P, Utz PJ (November 2002). "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". J. Exp. Med. 196 (9): 1213–25. doi:10.1084/jem.20021167. PMC 2194102. PMID 12417631.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Sato, T; Fujii, T; Yokoyama, T; Fujita, Y; Imura, Y; Yukawa, N; Kawabata, D; Nojima, T; Ohmura, K; Usui, T; Mimori, T (Dec 2010). "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease". Arthritis and rheumatism. 62 (12): 3730–40. doi:10.1002/art.27700. PMID 20722023.

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