Small nuclear ribonucleoprotein D1

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Protein SNRPD1 PDB 1b34.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesSNRPD1, HsT2456, SMD1, SNRPD, Sm-D1, Small nuclear ribonucleoprotein D1, small nuclear ribonucleoprotein D1 polypeptide
External IDsMGI: 98344 HomoloGene: 107532 GeneCards: SNRPD1
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for SNRPD1
Genomic location for SNRPD1
Band18q11.2Start21,612,267 bp[1]
End21,633,524 bp[1]
RNA expression pattern
PBB GE SNRPD1 202691 at fs.png

PBB GE SNRPD1 202690 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 18: 21.61 – 21.63 MbChr 18: 10.62 – 10.63 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.[5][6]


This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.[7]


Small nuclear ribonucleoprotein D1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167088 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002477 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lehmeier T, Raker V, Hermann H, Lührmann R (Dec 1994). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560.
  6. ^ Lehmeier T, Foulaki K, Lührmann R (Nov 1990). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Research. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240.
  7. ^ "Entrez Gene: SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa".
  8. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  9. ^ Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Molecular and Cellular Biology. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266.
  10. ^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
  11. ^ Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (Aug 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Human Molecular Genetics. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426.
  12. ^ Liu Q, Fischer U, Wang F, Dreyfuss G (Sep 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/s0092-8674(00)80367-0. PMID 9323129.
  13. ^ Friesen WJ, Dreyfuss G (Aug 2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". The Journal of Biological Chemistry. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
  14. ^ Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (Nov 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
  15. ^ Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (Feb 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/s0092-8674(00)80550-4. PMID 10025403.

Further reading[edit]