"Snake" achieved moderate success, reaching number sixteen at the United States' Hot 100, and the tenth position on the United Kingdom. A special double-A-side edition with "Thoia Thoing" was also released. The maxi-single charted at number ten in the Netherlands, number thirty in France, number sixteen in Australia and at number eighteen in Switzerland. A remix with actor and musician Cam'ron was also released.
R. Kelly and Big Tigger performed the song together during many live performances (including at Madison Square Garden in New York on the penultimate concert) during his 2003 tour and during the 2003 BET Awards. "Snake" received a special double A-side edition with "Thoia Thoing". The maxi-single charted at number ten in the Netherlands, number thirty in France, number sixteen in Australia and at number eighteen in Switzerland. A remix with Cam'ron was also released.
Cam'ron took R. Kelly to court in 2005 due to claims that he did not receive proper credit for his work on a remix of the song. Cam'ron filed a federallawsuit in New York. He had apparently written the introduction to the remix, as well as a part of the third verse but his songwriting contribution was not mentioned in the copyright when the song was featured on The R. in R&B Collection, Vol. 1, a greatest-hits album.