Reactive hypoglycemia

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Reactive hypoglycemia

Reactive hypoglycemia, postprandial hypoglycemia, or sugar crash is a term describing recurrent episodes of symptomatic hypoglycemia occurring within 4 hours[1] after a high carbohydrate meal in people who have diabetes.[2] It can also be present in non-diabetics.

The condition is related to homeostatic systems utilised by the body to control blood sugar levels. It is variously described as a sense of tiredness, lethargy, irritation, or hangover, although the effects can be less if a lot of physical activity is undertaken in the first few hours after food consumption.

The alleged mechanism for the feeling of a crash is correlated with an abnormally rapid rise in blood glucose after eating. This normally leads to insulin secretion (known as an insulin spike), which in turn initiates rapid glucose uptake by tissues either accumulating it as glycogen or utilizing it for energy production. The consequent fall in blood glucose is indicated as the reason for the "sugar crash".[3]. A deeper cause might be hysteresis effect of insulin action, i.e., the effect of insulin is still prominent even if both plasma glucose and insulin levels were already low, causing a plasma glucose level eventually much lower than the baseline level[4].

Sugar crashes are not to be confused with the after-effects of consuming large amounts of protein, which produces fatigue akin to a sugar crash, but are instead the result of the body prioritising the digestion of ingested food.[5]

The prevalence of this condition is difficult to ascertain because a number of stricter or looser definitions have been used. It is recommended that the term reactive hypoglycemia be reserved for the pattern of postprandial hypoglycemia which meets the Whipple criteria (symptoms correspond to measurably low glucose and are relieved by raising the glucose), and that the term idiopathic postprandial syndrome be used for similar patterns of symptoms where abnormally low glucose levels at the time of symptoms cannot be documented.

To assist diagnosis, a doctor can order an HbA1c test, which measures the blood sugar average over the two or three months before the test. The more specific 6-hour glucose tolerance test can be used to chart changes in the patient's blood sugar levels before ingestion of a special glucose drink and at regular intervals during the six hours following to see if an unusual rise or drop in blood glucose levels occurs.

According to the U.S. National Institute of Health (NIH), a blood glucose level below 70 mg/dL (3.9 mmol/L) at the time of symptoms followed by relief after eating confirms a diagnosis for reactive hypoglycemia.[1]

Signs and symptoms[edit]

Symptoms vary according to individuals' hydration level and sensitivity to the rate and/or magnitude of decline of their blood glucose concentration. A crash is usually felt within four hours or less of heavy carbohydrate consumption. Symptoms of reactive hypoglycemia include: [6] [7] [8]

  • double vision or blurry vision
  • unclear thinking
  • insomnia
  • heart palpitation or fibrillation
  • fatigue
  • dizziness
  • light-headedness
  • sweating
  • headaches
  • depression
  • nervousness
  • muscle twitches
  • irritability
  • tremors
  • flushing
  • craving sweets
  • increased appetite
  • rhinitis
  • nausea, vomiting
  • panic attack
  • numbness/coldness in the extremities
  • confusion
  • irrationality
  • bad temper
  • paleness
  • cold hands
  • disorientation
  • the need to sleep or 'crash'
  • coma can be a result in severe untreated episodes

The majority of these symptoms, often correlated with feelings of hunger, mimic the effect of inadequate sugar intake as the biology of a crash is similar in itself to the body’s response to low blood sugar levels following periods of glucose deficiency.[9]


The NIH states: "The causes of most cases of reactive hypoglycemia are still open to debate. Some researchers suggest that certain people may be more sensitive to the body’s normal release of the hormone epinephrine, which causes many of the symptoms of hypoglycemia. Others believe deficiencies in glucagon secretion might lead to reactive hypoglycemia.[1]

Stomach surgery or hereditary fructose intolerance are believed to be causes, albeit uncommon, of reactive hypoglycemia. myo-Inositol or D-chiro-inositol withdrawal can cause temporary reactive hypoglycemia.

There are several kinds of reactive hypoglycemia:[10]

  1. Alimentary hypoglycemia (consequence of dumping syndrome; it occurs in about 15% of people who have had stomach surgery)
  2. Hormonal hypoglycemia (e.g., hypothyroidism)
  3. Helicobacter pylori-induced gastritis (some reports suggest this bacteria may contribute to the occurrence of reactive hypoglycemia)[11]
  4. Congenital enzyme deficiencies (hereditary fructose intolerance, galactosemia, and leucine sensitivity of childhood)[12]
  5. Late hypoglycemia (occult diabetes; characterized by a delay in early insulin release from pancreatic β-cells, resulting in initial exaggeration of hyperglycemia during a glucose tolerance test)[13]

"Idiopathic reactive hypoglycemia" is a term no longer used because researchers now know the underlying causes of reactive hypoglycemia and have the tools to perform the diagnosis and the pathophysiological data explaining the mechanisms.[10]

To check if there is real hypoglycemia when symptoms occur, neither an oral glucose tolerance test nor a breakfast test is effective; instead, a hyperglucidic breakfast test or ambulatory glucose testing is the current standard.[10][14]

The body requires a relatively constant input of glucose, a sugar produced upon digestion of carbohydrates, for normal functioning. Glucagon and insulin are among the hormones that ensure a normal range of glucose in the human body.[15] Upon consumption of a meal, blood sugar normally rises, which triggers pancreatic cells to produce insulin. This hormone initiates the absorption of the just-digested blood glucose as glycogen into the liver for metabolism or storage, thereby lowering glucose levels in the blood. In contrast, the hormone glucagon is released by the pancreas as a response to lower than normal blood sugar levels. Glucagon initiates uptake of the stored glycogen in the liver into the bloodstream so as to increase glucose levels in the blood.[16] Sporadic, high-carbohydrate snacks and meals are deemed the specific causes of sugar crashes. The “crash” one feels is due to the rapid increase and subsequent decline of blood sugar in the body system as one begins and ceases consumption of high-sugar foods. More insulin than is actually needed is produced in response to the large, rapid ingestion of sugary foods.


To relieve reactive hypoglycemia, the NIH recommends taking the following steps:[1]

  • Avoiding or limiting sugar intake;[17]
  • Exercising regularly; exercise increases sugar uptake which decreases excessive insulin release
  • Eating a variety of foods, including meat, poultry, fish, or nonmeat sources of protein, foods such as whole-grains, fruits, nuts, vegetables, and dairy products;
  • Choosing high-fiber foods.

Other tips to prevent sugar crashes include:

  • Avoiding eating meals or snacks composed entirely of carbohydrates; simultaneously ingest fats and proteins, which have slower rates of absorption.
  • Consistently choosing longer lasting, complex carbohydrates to prevent rapid blood-sugar dips in the event that one does consume a disproportionately large amount of carbohydrates with a meal
  • Monitoring any effects medication may have on symptoms.[3]

Low-carbohydrate diet and/or frequent small split meals is the first treatment of this condition. The first important point is to add small meals at the middle of the morning and of the afternoon, when glycemia would start to decrease. If adequate composition of the meal is found, the fall in blood glucose is thus prevented. Patients should avoid rapidly absorbable sugars and thus avoid popular soft drinks rich in glucose or sucrose. They should also be cautious with drinks associating sugar and alcohol, mainly in the fasting state.[10]

As it is a short-term ailment, a sugar crash does not usually require medical intervention in most people. The most important factors to consider when addressing this issue are the composition and timing of foods.[18] Acute low blood sugar symptoms are best treated by consuming small amounts of sweet foods, so as to regain balance in the body’s carbohydrate metabolism. Suggestions include sugary foods that are quickly digested, such as:

  • Dried fruit
  • Soft drinks
  • Juice
  • Sugar as sweets, tablets or cubes.[19]

Postprandial syndrome[edit]

If there is no hypoglycemia at the time of the symptoms, this condition is called "postprandial syndrome." It might be an "adrenergic postprandial syndrome" — blood glucose levels are normal, but the symptoms are caused through autonomic adrenergic counterregulation.[20] Often, this syndrome is associated with emotional distress and anxious behaviour of the patient.[10] This is often seen in dysautonomic disorders as well. Dietary recommendations for reactive hypoglycemia can help to relieve symptoms of postprandial syndrome.

See also[edit]


  1. ^ a b c d "Hypoglycemia." It can also be referred to as "sugar crash" or "glucose crash." National Diabetes Information Clearinghouse, October 2008.
  2. ^ "Hypoglycemia". National Institute of Diabetes and Digestive and Kidney Diseases. October 2008. Retrieved 28 June 2015. 
  3. ^ a b Hendrickson, Kirstin. "Side Effects of a Sugar Overdose". Demand Media, Inc. Retrieved 8 November 2011. 
  4. ^ Wang, Guanyu (Oct 15, 2014). "Raison d'être of insulin resistance: the adjustable threshold hypothesis". J R Soc Interface. 11: 20140892. doi:10.1098/rsif.2014.0892. PMC 4223910Freely accessible – via The Royal Society. 
  5. ^ "The Truth about Tryptophan". WebMD. 
  6. ^ "Hypoglycemia". National Diabetes Information Clearinghouse. U.S. Department of Health and Human Services. Retrieved 8 November 2011. 
  7. ^ "Hypoglycemia". Mayo Foundation for Medical Education and Research. Mayo Clinic. Retrieved 8 November 2011. 
  8. ^ Simpson, Jamie. "Causes of Low Blood Sugar". Demand Media. Retrieved 8 November 2011. 
  9. ^ "Diabetes". American Dietetic Association. Retrieved 11 November 2011. 
  10. ^ a b c d e J.F. Brun, C. Fedou, J. Mercier, "Postprandial Reactive Hypoglycemia," Diabetes & Metabolism (Paris) 2000, 26, 337-351
  11. ^ Açbay O, Celik AF, Kadioğlu P, Göksel S, Gündoğdu S (1999). "Helicobacter pylori-induced gastritis may contribute to occurrence of postprandial symptomatic hypoglycemia". Dig. Dis. Sci. 44 (9): 1837–42. doi:10.1023/A:1018842606388. PMID 10505722. 
  12. ^ "eMedicine - Hypoglycemia : Article by Vasudevan A Raghavan". Retrieved 2007-07-06. 
  13. ^ Umesh Masharani (2007). "Postprandial Hypoglycemia (Reactive Hypoglycemia)". The Hypoglycemic states - Hypoglycemia. Armenian Medical Network. 
  14. ^ I Berlin, A Grimaldi, C Landault, F Cesselin and A J Puech, "Suspected postprandial hypoglycemia is associated with beta-adrenergic hypersensitivity and emotional distress," Journal of Clinical Endocrinology & Metabolism, November 1994
  15. ^ "How the Body Controls Blood Sugar". Web MD Diabetes. Healthwise Incorporated. Retrieved 8 November 2011. 
  16. ^ "Hypoglycemia". Hormonal and Metabolic Disorders. Merck Sharp & Dohme Corp. Retrieved 8 November 2011. 
  17. ^ Kenrose, S. The Reactive Hypoglycemia Sourcebook, 2009. ISBN 978-0-557-07407-5"
  18. ^ Collazo-Clavell, Maria. "Reactive Hypoglycemia". Mayo Foundation for Medical Education and Research. Retrieved 11 November 2011. 
  19. ^ "Hypoglycemia (Low Blood Sugar) in People Without Diabetes". Diabetes Health Center. WebMD, LLC. Retrieved 8 November 2011. 
  20. ^ "Postprandial Hypoglycemia". Retrieved 29 November 2011. 

Further reading[edit]

  • Açbay O, Celik AF, Kadioğlu P, Göksel S, Gündoğdu S (1999). "Helicobacter pylori-induced gastritis may contribute to occurrence of postprandial symptomatic hypoglycemia". Dig. Dis. Sci. 44 (9): 1837–42. doi:10.1023/A:1018842606388. PMID 10505722. 

External links[edit]