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TRNA (adenine57-N1/adenine58-N1)-methyltransferase

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TRNA (adenine57-N1/adenine58-N1)-methyltransferase
Identifiers
EC no.2.1.1.219
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

TRNA (adenine57-N1/adenine58-N1)-methyltransferase (EC 2.1.1.219, TrmI, PabTrmI, AqTrmI, MtTrmI) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine57/adenine58-N1)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction:

2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs .

References

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  1. ^ Roovers M, Wouters J, Bujnicki JM, Tricot C, Stalon V, Grosjean H, Droogmans L (2004). "A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase". Nucleic Acids Research. 32 (2): 465–76. doi:10.1093/nar/gkh191. PMC 373318. PMID 14739239.
  2. ^ Guelorget A, Roovers M, Guérineau V, Barbey C, Li X, Golinelli-Pimpaneau B (October 2010). "Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase". Nucleic Acids Research. 38 (18): 6206–18. doi:10.1093/nar/gkq381. PMC 2952851. PMID 20483913.
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