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why is its efficacy unknown? Somebody do a test! - ShadowyCabal 11:38, 6 September 2006 (UTC)

citing sources[edit]

There are many statements here that need specific references to particular studies or effects, please add them if you know the correct study for the source. thanks


The toxicity information is not accurate and requires reference. And the idea that it should be taken once a day is silly. Goldenseal should be used with care- I reserve it for pneumonia and diseases of the mucosa where it has an affinity. But it can be dosed throughout the day. KSVaughan 20:47, 11 May 2007 (UTC)

And elsewhere it said it could be taken as a vitamin or to recover from exercise. I removed that which is erroneous as this is not an adaptogen or even a food grade herb. Karen S Vaughan 04:45, 15 May 2007 (UTC)


This section contains information antithetical to the research cited as far as toxicity. I find no mention of any Hotaki study in Medline or Medscape, and if in vitro studies did show a reduction in sperm count it would only mean that you shouldn't put sperm in a testtube with goldenseal before implanting them. I am removing the section. Karen S Vaughan 01:22, 14 May 2007 (UTC)

The information on toxicity and LD50 of berberine are incorrect. Berberine chloride was used at 15mg/kg in rats with colitis and decreased intestinal inflammation, I don't think a dose of 27mg/kg would be lethal in humans.

The Effect of Berberine Chloride on Experimental Colitis in Rats In Vivo and In Vitro Haiyan Zhou and Satoru Mineshita (talk) 05:52, 11 December 2007 (UTC)David Hammond

Article Substantially Rewritten[edit]

The article has been substantially rewritten. Karen S Vaughan 16:48, 15 May 2007 (UTC)


Added links and backlinks to Berberine as they are deeply interesting and interelated pharmacological discussions going on here. Cheers, 22:19, 2 December 2007 (UTC)

Completely unclear sentence[edit]

This sentence could have any number of meanings, none of which is clear from its wording:

"According to Herbalist Paul Bergner,AHG, only 10% of goldenseal is used when it is appropriate and there are no better substitutes. [22] "

Perhaps someone knowledgeable in the subject who is also familiar with the fundamentals of clear writing could rephrase it. —Preceding unsigned comment added by Daqu (talkcontribs) 10:41, 3 November 2008 (UTC)

Endangered but Apparently Secure?[edit]

Why is there a whole section on how Endangered this plan is when it's listed as 'Apparently Secure' on the Conservation Status? One of these contradictory points should be changed shouldn't it? —Preceding unsigned comment added by (talk) 04:41, 8 April 2010 (UTC)

Yeah, I agree. It says it is secure but later in the article it says it is endangered and overharvested. (talk) 05:12, 18 May 2013 (UTC)


Apart from the intro and 'Endangered' section which discuss the plant, the rest of the article seems to discuss the medicinal extract. Can someone confirm the extract is just from the rhizome, and say how it is processed. Is it just ground and dried, or is it just the extracted alkaloids, extracted with what solvent ? Rod57 (talk) 10:06, 6 January 2011 (UTC)

How goldenseal works[edit]

Using this language ("How goldenseal works") in an encyclopedia gives the audience the impression that the section will discuss the reductionist mechanics of the process, and that goldenseal has been proven to be effective by the given mechanics. What follows however, is a correlation, and one study's guess involving more mucus flow. Perhaps the modern pharm section should be intigrated with all this into a "Possible Mechanics" section??? —Preceding unsigned comment added by (talk) 17:38, 18 March 2011 (UTC)

Goldenseal is dangerous!!![edit]

Goldenseal alkaloids are phototoxic to eye keratinocytes. A study on their effect on human lens and retinal pigment epithelial cells showed that human lens epithelial cells (HLE-B3) were severely damaged when incubated with berberine (25 microM) and exposed to UVA (5 J cm(-2)). The study concluded that eyewashes and lotions derived from Goldenseal or containing berberine must be used with caution when the eyes are exposed to bright sunlight, however oral preparations are not likely to cause ocular phototoxicity (1).

Botanical supplements containing goldenseal strongly inhibited CYP2D6 and CYP3A4/5 activity in vivo, so serious adverse interactions may result from the concomitant ingestion of goldenseal supplements and drugs that are CYP2D6 and CYP3A4/5 substrates (2).

A 2-year study showed there was clear evidence of carcinogenic activity of goldenseal root powder in male F344/N rats based on the increased incidences of hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined). There was also clear evidence of carcinogenic activity of goldenseal root powder in female F344/N rats based on the increased incidence of hepatocellular adenoma. There was some evidence of carcinogenic activity of goldenseal root powder in male B6C3F1 mice based on the increased incidences of hepatoblastoma and multiple hepatocellular adenoma. There was no evidence of carcinogenic activity of goldenseal root powder in female B6C3F1 mice exposed to 3,000, 9,000, or 25,000 ppm goldenseal root powder in feed for 2 years. The study concluded that administration of goldenseal root powder resulted in increased incidences of non-neoplastic lesions in the liver of male and female rats and male mice (3).

Another 2 years study was conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. The study showed that goldenseal root powder increased the risk for liver tumors in rats and mice. The increased tumorigenicity in rodents exposed to goldenseal root powder may be due in part to the topoisomerase inhibition properties of berberine, a major alkaloid constituent in goldenseal, or its metabolite, berberrubine (4).

According to the above, goldenseal, does not seem safe - especially if taken for long term, so its use is still not recommended. 688dim (talk) 11:44, 15 April 2011 (UTC)

1 * 2 * 3 * 4 *


"Interestingly, there is some evidence for other berberine-containing species synthesizing an efflux pump inhibitor that tends to prevent antibiotic resistance, a case of solid scientific evidence that the herb is superior to the isolated active principle." What is the word "superior" supposed to mean here?--Frglz (talk) 04:07, 28 May 2013 (UTC)

UpS Advertising Spam, Original Research and Endangered Status[edit]

Removed external link to United Plant Savers. Link was to an advertisement for Herb Pharm brand Goldenseal ($15/oz). "Organization" also claims that this plant is "at-risk" contray to NatureServe status and general consensus. The section of the article regarding status currently misrepresent the facts of the matter and is generally misleading. This plant is not endangered (Appendix I), although the living plant is partially regulated under Appendix II of CITES, which means it may be monitored (i.e. harvest from public land is prohibited) but it's trade is still deemed undetrimental to survival of wildlife populations. Since first being listed under schedule II in 1997 there have been several petitions from official orginizations appealing to have the plant droped from CITES schedule all together. Unlike the living plant, products containing goldenseal powder are currently unregulated for trade. Claims of overharvesting and extinction scare tactics are debatable at best, and in most cases verifiably false. The United Plant Saver organization seems to be at the center of an on-going advertisment (and possible misinformation) campaign that focuses on herbs that are currently being popularized in televised media (i.e. History Channel's Appalachian Outlaws) to boost site traffic via bulk external links and pagerank garnered from wikipedia during this period of increased public interest. (talk) 14:06, 13 January 2014 (UTC)


Added image of Goldenseal in fruit, it is a personal image, unsure if it needs a citation. Mustangracer05 (talk) 17:18, 28 June 2016 (UTC)

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