Talk:Grape seed extract

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Percent Resveratol in extracts?[edit]

Could someone add what the typical percent of the polyphenols in grape seed extracts are resveratol? —Preceding unsigned comment added by (talk) 22:35, 13 July 2008 (UTC)


This article really needs inline citations to support many of its claims. Please see Wikipedia:Verifiability and Wikipedia:Citing sources for guidance. Deli nk (talk) 20:42, 21 June 2008 (UTC)

List of papers by Ray[edit]

I've formatted a recently added list of papers for legibility [1]. I'm sure that they are not presented correctly, and may not even need to be in the article at all, but I'll leave that to those who are more involved. Meters (talk) 19:39, 11 July 2012 (UTC)

I don't think it is appropriate to include a long list of references that are not used to support any of the article text (particularly when all of them are from only one researcher). But they may be useful resources for anyone wishing to expand the article, so I have moved them here. -- Ed (Edgar181) 20:57, 11 July 2012 (UTC)
  • Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Current Neurovascular Research, 2012 Feb;9(1):58-71.
  • Bulku E, Zinkovsky D, Patel P, Javia V, Lahoti T, Khodos I, Stohs SJ and Ray SD. A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes. Oxidative Medicine & Cellular Longevity. 3(2):129-144, 2010.
  • Patel N, Joseph C, Corcoran GB and Ray SD. Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. Toxicol. Appl. Pharmacol. 245 143-152, 2010.
  • Ray SD, Parmar M, Rathod J, Ismail S, Zinkovsky D, Bulku E, Gigliotti J, Hackman RM and Stohs S J. Long Term Exposure Effect of a Unique Metabolic Nutrition System Containing a Diverse Group Of Phytochemicals on Serum Chemistry and Genomic and Non-Genomic Changes in the Liver of Female B6C3F1 Mice. Phytotherapy Research 22(4): 458-471, 2008.
  • Ray SD, Patel N, Nagori A, Naqvi A and Stohs SJ. Four week exposure to a novel nutritional mixture containing a series of polyphenolic phytochemicals antagonizes acetaminophen-induced programmed and unprogrammed cell death in the liver in vivo. Molecular and Cellular Biochemistry, 293(1-2):119-36, 2006.
  • Ray SD. et. al. Roles of Polyphenols, Flavonoids, and Oligomeric Proanthocyanidins in Cancer Chemoprevention’ in ‘Phytopharmaceuticals in Cancer Chemoprevention’, Eds. H. G. Preuss and D. Bagchi, CRC Press, Pp. 311-348, [ISBN#08493-1560-3], 2005. [Book Chapter]
  • Ray SD, Parikh H and Bagchi D. Long-Term grape seed proanthocyanidin extract exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths. Mutation Research 579 (1-2): 81-106, 2005.
  • Ray, SD et al. Oxidative Stress is the Master Operator of Drug & Chemically-Induced Programmed & Unprogrammed Cell Death: Implications of Natural Antioxidants In Vivo. Biofactors, 21(1-4):223-232, 2004.
  • Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG and Vinson JA. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutatation Research 523-524:87-97, 2003.
  • Bagchi D, Bagchi M, Stohs SJ, Ray SD, Sen CK and Preuss HG. Cellular protection with proanthocyanidins derived from grape seeds. Ann New York Acad Sciences 957:260-70; 2002.
  • Ray SD, Parikh H, Hickey E, Bagchi M, and Bagchi D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal CYP-4502E1 dependent aniline hydroxylation. Molecular & Cellular Biochemistry, 218: 27-33, 2001.
  • Ray S, Bagchi D, Lim PM, Bagchi M, Gross SM, Kothari SC, Preuss HG, Stohs SJ. Acute and long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract. Res Commun Mol Pathol Pharmacol., 109(3- 4):165-97, 2001.
  • Ray, S. D., Patel, D., Wong, V., Rinkovsky, A., Bagchi, M., Raje, R. R. and Bagchi, D. Unique organoprotective properties of a novel a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine-induced spleenotoxicity, and mocap-induced neurotoxicity in mice. Res. Commu. Mol. Pathol. & Pharmacol., 107: 105-128, 2000.
  • Ray, S. D., Patel, D., Wong, V. and Bagchi, D. In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract. Res. Commu. Mol. Pathol. & Pharmacol., 107: 137-166, 2000.
  • Bagchi, D., Ray, S. D., Patel, D. and Bagchi, M. Protection against drug- and chemically-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exptl. Clin. Res., 27: 3-15, 2000.
  • Bagchi, D ., Bagchi, M., Stohs, S., Das, D. K., Ray, S. D., Kuszynski, C. A., Joshi, S. and Preuss, H. G. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-197, 2000.
  • Ray, S.D., Kumar, A. and Bagchi, D. A novel proanthocyanidin IH636 extract increases in vivo bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch. Biochem. Biophys., 369: 42-58, 1999.

Relevance of other grape products here?[edit]

Under "Health effects", it says very little reliable scientific evidence available at this time that drinking red wine, eating grapes, or following the grape diet.

The first two and possibly the third don't seem to have much if anything to do wth grape seed extract. Am I missing something? Chriswaterguy talk 11:52, 30 April 2016 (UTC)

Agree. I removed that ACS reference as non-specific to GSE and edited the article with what is available as general information. Fyi, there are numerous assessments by the EFSA of GSE ineffectiveness for individual health conditions, such as this showing no cause and effect relationship can be demonstrated. --Zefr (talk) 14:55, 30 April 2016 (UTC)