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Needs expert opinion
This page, locus ceruleus, needs to be edited by an expert. I began to edit, but I am just a med student and do not have the time/expretise on the subject. Many of teh facts are fuzzy or questionable and there are no citations. __ I absolutely agree. This is a structure that plays a fundamental role not only in general arousal (i.e. alertness, drowsiness, etc.) but also plays a critical role in response selection during general task performance. The LC appears to play a large role in the extent to which we persist in optimizing human performance through the distribution of NE. It's a critical structure for behavior in general, and so some of that should be in here. I'm sure its role in PTSD is important, but that's perhaps a side-effect of what the structure actually DOES. Doesn't quite make sense that we have a little PTSD machine in our heads, eh? 184.108.40.206 05:05, 30 August 2007 (UTC)
As someone without any knowledge about this, I do not find the picture very enlightening. I would suggest that a picture with the LC clearly labeled would better fit in this article. The current picture seems quite old, and while that is not a bad thing on its own, maybe research has produced a more precise modern image. From the view of someone who is not a neurologist, its not even clear in what section of the brain this part is located. —Preceding unsigned comment added by 220.127.116.11 (talk) 07:11, 12 October 2010 (UTC)
PTSD candidate circuit?
I suggest changing the main usage in this page to coeruleus (with the "oe"), rather than ceruleus. Although some people do prefer the term "ceruleus" (without the "o" -- a la the color "cerulean"), it is not the term used by the majority of scientists and neuroanatomists.
For example, a search for "locus coeruleus" using PubMed (the major repository for all meaningful biomedical research articles world-wide) returned 6646 articles, whereas "locus ceruleus" returned 1015 (many of which in fact used "coeruleus" in their text, but included "ceruleus" as a "Keyword" so that their article would not be missed in a search using the uncommon term; restricting the search to titles only resulted in 2032 "coeruleus" to 212 "ceruleus"). To make sure that "coeruleus" wasn't simply the preferred term many years ago (as suggested by the present version of this Wikipedia article), I restricted the results to the past five years (2004-2009), and the difference was just as large: 937 articles with "coeruleus" to just 152 with "ceruleus" (again, a six-to-one ratio). As an aside, "locus caeruleus" returned only 62 total hits (10 from the last 5 years).
My recommendation: avoid confusion (it's not like omitting the "o" makes this word any less ugly!) and stick with the established -- and more common -- nomenclature. Joel.geerling (talk) 21:46, 10 February 2009 (UTC)
The current edition of Terminologia Anatomica dictates "Nucleus caeruleus" (A14.1.05.436) in its list of Latin expressions but mentions "caerulean nucleus" in its list of English equivalents. In this classification the term "Locus caeruleus" (A14.1.05.706) corresponds to an area of the rhomboid fossa (floor of fourth ventricle). A current search for the term in Pubmed gives the following results. "Locus coeruleus" 6598 articles "Locus ceruleus" 1171 "Locus caeruleus" 73 "Locus coeruleus complex" 44 "Locus caeruleus complex" 6 "Loci coerulei" 7 "Loci cerulei" 2 "Caerulean nucleus" 0 "Nucleus caeruleus" 0
New subsection: Possible role in ASD
Would something on these lines be appropriate?
Research at Albert Einstein College of Medicine of Yeshiva University has suggested that the locus coeruleus - noradrenergic system (LC-NA) may be involved in autistic spectrum symptoms. They note that, "What is unique about the locus coeruleus is that it activates almost all higher-order brain centers that are involved in complex cognitive tasks." Yeshiva University news release Davy p (talk) 00:15, 21 April 2009 (UTC)
It has been said that...
I removed a logical impossibility: "...a single noradrenergic neuron can innervate the entire cerebral cortex via its branches" which had recently been tagged citation needed. The author may have been thinking of Olson & Fuxe 1971 which says that one single noradrenergic neuron of the rat LC can innervate both the cerebral and cerebellar cortices. (Cited in Léger & Hernandez-Nicaise 1980) Anthony (talk) 12:46, 10 February 2010 (UTC)