Galactoside O-acetyltransferase

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Galactoside O-acetyltransferase
Identifiers
EC number 2.3.1.18
CAS number 9029-94-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Thiogalactoside acetyltransferase
Identifiers
Organism Escherichia coli
Symbol lacA
Entrez 945674
RefSeq (Prot) NP_414876
UniProt P07464

Galactoside O-acetyltransferase (also known as thiogalactoside transacetylase) is an enzyme encoded by the lacA gene in E. coli. The protein plays a role in cell detoxification.[1]

Reaction[edit]

It catalyzes the following reaction:

acetyl-CoA + beta-D-galactosideCoA + 6-acetyl-beta-D-galactoside

Structure[edit]

In E. coli, thiogalactoside transacetylase is a dimer. Its monomer consists of 202 amino acid residues. The protein has a molecular weight of 22,671.[2]

The amino terminus of the protein is heterogenous because the initiator methionine is only partially cleaved. The protein is found in the cell cytoplasm and contains a highly hydrophobic segment in its center.

See also[edit]

References[edit]

  1. ^ "Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification.". 1976. 
  2. ^ "The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.". Biochimie. 67 (1): 101–8. 1985. doi:10.1016/s0300-9084(85)80235-2. PMID 3922433.