Thymidine kinase from herpesvirus
| Thymidine kinase from herpesvirus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of thymidine kinase from herpesvirus.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | Herpes_TK | ||||||||||
| Pfam | PF00693 | ||||||||||
| InterPro | IPR001889 | ||||||||||
| SCOP2 | 1kin / SCOPe / SUPFAM | ||||||||||
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Thymidine kinase from herpesvirus is a sub-family of thymidine kinases.[2]
Its presence in herpesvirus-infected cells is used to activate a range of antivirals against herpes infection, and thus specifically target the therapy towards infected cells only.
Such antivirals include:
- Purine analogues of guanine: Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir
- Vidarabine
- Pyrimidine analogues of uridine: Idoxuridine, Trifluridine
- Brivudine
References
- ^ Champness JN, Bennett MS, Wien F; et al. (August 1998). "Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands". Proteins. 32 (3): 350–61. doi:10.1002/(SICI)1097-0134(19980815)32:3<350::AID-PROT10>3.0.CO;2-8. PMID 9715911.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Brown DG, Visse R, Sandhu G, Davies A, Rizkallah PJ, Melitz C, Summers WC, Sanderson MR (October 1995). "Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir". Nat. Struct. Biol. 2 (10): 876–81. doi:10.1038/nsb1095-876. PMID 7552712.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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