Tropine acyltransferase
| Tropine acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.185 | ||||||||
| CAS no. | 162535-29-7&title= 138440-79-6, 162535-29-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tropine acyltransferase (EC 2.3.1.185, tropine:acyl-CoA transferase, acetyl-CoA:tropan-3-ol acyltransferase, tropine acetyltransferase, tropine tigloyltransferase, TAT) is an enzyme with systematic name acyl-CoA:tropine O-acyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
This enzyme exhibits absolute specificity for the endo/3alpha configuration found in tropine as pseudotropine.
References
- ^ Robins, R.J.; Bachmann, P.; Robinson, T.; Rhodes, M.J.; Yamada, Y. (1991). "The formation of 3α- and 3β-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases". FEBS Lett. 292: 293–297. doi:10.1016/0014-5793(91)80887-9. PMID 1959620.
- ^ Robins, R.J.; Bachmann,P.; Peerless, A.C.J.; Rabot, S. (1994). "Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures". Plant Cell, Tissue Organ Cult. 38: 241–247. doi:10.1007/bf00033883.
- ^ Boswell, H.D.; Dräger, B.; McLauchlan, W.R.; Portsteffen, A.; Robins, D.J.; Robins, R.J.; Walton, N.J. (1999). "Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura". Phytochemistry. 52: 871–878. doi:10.1016/S0031-9422(99)00293-9. PMID 10626376.
- ^ Li, R.; Reed, D.W.; Liu, E.; Nowak, J.; Pelcher, L.E.; Page, J.E.; Covello, P.S. (2006). "Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement". Chem. Biol. 13: 513–520. doi:10.1016/j.chembiol.2006.03.005. PMID 16720272.
External links
- Tropine+acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)