Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 02:03, 11 October 2007 (UTC)[edit]
Conflict: Ambiguous Proteins (2)[edit]
Redirected Proteins (13)[edit]
Manual Inspection (Parsing Error) (12)[edit]
Manual Inspection (Page not found) (2)[edit]
Updated (1)[edit]
Protein Status Grid - Date: 02:03, 11 October 2007 (UTC)[edit]
Vebose Log - Date: 02:03, 11 October 2007 (UTC)[edit]
- INFO: Beginning work on ADIPOQ... {October 10, 2007 6:58:50 PM PDT}
- SEARCH: Multiple Conflicting Pages. Need Resolution. {October 10, 2007 6:59:24 PM PDT}
- AMBIGUITY: More than one potential page found for updating, Adiponectin Adiponectin Adiponectin {October 10, 2007 6:59:24 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1c28}}, {{PDB2|1c3h}}
| Name = Adiponectin, C1Q and collagen domain containing
| HGNCid = 13633
| Symbol = ADIPOQ
| AltSymbols =; ACDC; ACRP30; APM-1; APM1; GBP28; adiponectin
| OMIM = 605441
| ECnumber =
| Homologene = 3525
| MGIid = 106675
| GeneAtlas_image1 = PBB_GE_ADIPOQ_207175_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006635 |text = fatty acid beta-oxidation}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0009749 |text = response to glucose stimulus}} {{GNF_GO|id=GO:0042593 |text = glucose homeostasis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045721 |text = negative regulation of gluconeogenesis}} {{GNF_GO|id=GO:0045923 |text = positive regulation of fatty acid metabolic process}} {{GNF_GO|id=GO:0046326 |text = positive regulation of glucose import}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9370
| Hs_Ensembl = ENSG00000181092
| Hs_RefseqProtein = NP_004788
| Hs_RefseqmRNA = NM_004797
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 188043157
| Hs_GenLoc_end = 188058944
| Hs_Uniprot = Q15848
| Mm_EntrezGene = 11450
| Mm_Ensembl = ENSMUSG00000022878
| Mm_RefseqmRNA = NM_009605
| Mm_RefseqProtein = NP_033735
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 23061870
| Mm_GenLoc_end = 23073302
| Mm_Uniprot = Q6GTX4
}}
}}
'''Adiponectin, C1Q and collagen domain containing''', also known as '''ADIPOQ''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes.<ref>{{cite web | title = Entrez Gene: ADIPOQ adiponectin, C1Q and collagen domain containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9370| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ukkola O, Santaniemi M |title=Adiponectin: a link between excess adiposity and associated comorbidities? |journal=J. Mol. Med. |volume=80 |issue= 11 |pages= 696-702 |year= 2003 |pmid= 12436346 |doi= 10.1007/s00109-002-0378-7 }}
*{{cite journal | author=Díez JJ, Iglesias P |title=The role of the novel adipocyte-derived hormone adiponectin in human disease. |journal=Eur. J. Endocrinol. |volume=148 |issue= 3 |pages= 293-300 |year= 2003 |pmid= 12611609 |doi= }}
*{{cite journal | author=Vasseur F, Leprêtre F, Lacquemant C, Froguel P |title=The genetics of adiponectin. |journal=Curr. Diab. Rep. |volume=3 |issue= 2 |pages= 151-8 |year= 2003 |pmid= 12728641 |doi= }}
*{{cite journal | author=Matsuzawa Y, Funahashi T, Kihara S, Shimomura I |title=Adiponectin and metabolic syndrome. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 1 |pages= 29-33 |year= 2004 |pmid= 14551151 |doi= 10.1161/01.ATV.0000099786.99623.EF }}
*{{cite journal | author=Nedvídková J, Smitka K, Kopský V, Hainer V |title=Adiponectin, an adipocyte-derived protein. |journal=Physiological research / Academia Scientiarum Bohemoslovaca |volume=54 |issue= 2 |pages= 133-40 |year= 2006 |pmid= 15544426 |doi= }}
*{{cite journal | author=Hug C, Lodish HF |title=The role of the adipocyte hormone adiponectin in cardiovascular disease. |journal=Current opinion in pharmacology |volume=5 |issue= 2 |pages= 129-34 |year= 2005 |pmid= 15780820 |doi= 10.1016/j.coph.2005.01.001 }}
*{{cite journal | author=Hara K, Yamauchi T, Kadowaki T |title=Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans. |journal=Curr. Diab. Rep. |volume=5 |issue= 2 |pages= 136-40 |year= 2005 |pmid= 15794918 |doi= }}
*{{cite journal | author=Menzaghi C, Trischitta V, Doria A |title=Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. |journal=Diabetes |volume=56 |issue= 5 |pages= 1198-209 |year= 2007 |pmid= 17303804 |doi= 10.2337/db06-0506 }}
*{{cite journal | author=Lara-Castro C, Fu Y, Chung BH, Garvey WT |title=Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 263-70 |year= 2007 |pmid= 17495599 |doi= 10.1097/MOL.0b013e32814a645f }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ARNTL... {October 10, 2007 6:52:41 PM PDT}
- SEARCH REDIRECT: Control Box Found: ARNTL {October 10, 2007 6:53:15 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: ARNTL. Invoking a Mandantory Inspection. {October 10, 2007 6:53:17 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aryl hydrocarbon receptor nuclear translocator-like
| HGNCid = 701
| Symbol = ARNTL
| AltSymbols =; BMAL1; BMAL1c; JAP3; MGC47515; MOP3; PASD3; TIC
| OMIM = 602550
| ECnumber =
| Homologene = 910
| MGIid = 1096381
| GeneAtlas_image1 = PBB_GE_ARNTL_210971_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARNTL_209824_s_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 406
| Hs_Ensembl = ENSG00000133794
| Hs_RefseqProtein = NP_001025443
| Hs_RefseqmRNA = NM_001030272
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 13255921
| Hs_GenLoc_end = 13365345
| Hs_Uniprot = O00327
| Mm_EntrezGene = 11865
| Mm_Ensembl = ENSMUSG00000055116
| Mm_RefseqmRNA = NM_007489
| Mm_RefseqProtein = NP_031515
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 112998646
| Mm_GenLoc_end = 113105303
| Mm_Uniprot = Q3UHZ2
}}
}}
'''Aryl hydrocarbon receptor nuclear translocator-like''', also known as '''ARNTL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ARNTL aryl hydrocarbon receptor nuclear translocator-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=406| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CREBBP... {October 10, 2007 6:53:17 PM PDT}
- SEARCH REDIRECT: Control Box Found: CREB binding protein {October 10, 2007 6:53:43 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=CREB binding protein>CREB binding protein</a> {October 10, 2007 6:53:51 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 10, 2007 6:53:58 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 10, 2007 6:53:58 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 10, 2007 6:53:58 PM PDT}
- UPDATED: Updated protein page: CREB binding protein {October 10, 2007 6:54:05 PM PDT}
- INFO: Beginning work on CRY1... {October 10, 2007 6:54:05 PM PDT}
- SEARCH REDIRECT: Control Box Found: CRY1 {October 10, 2007 6:54:18 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: CRY1. Invoking a Mandantory Inspection. {October 10, 2007 6:54:21 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cryptochrome 1 (photolyase-like)
| HGNCid = 2384
| Symbol = CRY1
| AltSymbols =; PHLL1
| OMIM = 601933
| ECnumber =
| Homologene = 7042
| MGIid = 1270841
| GeneAtlas_image1 = PBB_GE_CRY1_209674_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003913 |text = DNA photolyase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008020 |text = G-protein coupled photoreceptor activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1407
| Hs_Ensembl = ENSG00000008405
| Hs_RefseqProtein = NP_004066
| Hs_RefseqmRNA = NM_004075
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 105909289
| Hs_GenLoc_end = 106011737
| Hs_Uniprot = Q16526
| Mm_EntrezGene = 12952
| Mm_Ensembl = ENSMUSG00000020038
| Mm_RefseqmRNA = NM_007771
| Mm_RefseqProtein = NP_031797
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 84561499
| Mm_GenLoc_end = 84614853
| Mm_Uniprot = P97784
}}
}}
'''Cryptochrome 1 (photolyase-like)''', also known as '''CRY1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRY2... {October 10, 2007 6:54:21 PM PDT}
- SEARCH REDIRECT: Control Box Found: CRY2 {October 10, 2007 6:54:39 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: CRY2. Invoking a Mandantory Inspection. {October 10, 2007 6:54:41 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cryptochrome 2 (photolyase-like)
| HGNCid = 2385
| Symbol = CRY2
| AltSymbols =; FLJ10332; HCRY2; KIAA0658; PHLL2
| OMIM = 603732
| ECnumber =
| Homologene = 56466
| MGIid = 1270859
| GeneAtlas_image1 = PBB_GE_CRY2_212695_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003913 |text = DNA photolyase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0048511 |text = rhythmic process}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1408
| Hs_Ensembl = ENSG00000121671
| Hs_RefseqProtein = NP_066940
| Hs_RefseqmRNA = NM_021117
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 45825605
| Hs_GenLoc_end = 45861372
| Hs_Uniprot = Q49AN0
| Mm_EntrezGene = 12953
| Mm_Ensembl = ENSMUSG00000068742
| Mm_RefseqmRNA = XM_994658
| Mm_RefseqProtein = XP_999752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 92204485
| Mm_GenLoc_end = 92234867
| Mm_Uniprot = Q99JJ1
}}
}}
'''Cryptochrome 2 (photolyase-like)''', also known as '''CRY2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSNK1E... {October 10, 2007 6:54:41 PM PDT}
- SEARCH REDIRECT: Control Box Found: CSNK1E {October 10, 2007 6:55:03 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: CSNK1E. Invoking a Mandantory Inspection. {October 10, 2007 6:55:05 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSNK1E_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cki.
| PDB = {{PDB2|1cki}}, {{PDB2|1ckj}}
| Name = Casein kinase 1, epsilon
| HGNCid = 2453
| Symbol = CSNK1E
| AltSymbols =; HCKIE; MGC10398
| OMIM = 600863
| ECnumber =
| Homologene = 37548
| MGIid = 1351660
| GeneAtlas_image1 = PBB_GE_CSNK1E_202332_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004681 |text = casein kinase I activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1454
| Hs_Ensembl = ENSG00000100181
| Hs_RefseqProtein = NP_001885
| Hs_RefseqmRNA = NM_001894
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 37017870
| Hs_GenLoc_end = 37124473
| Hs_Uniprot = P49674
| Mm_EntrezGene = 27373
| Mm_Ensembl = ENSMUSG00000022433
| Mm_RefseqmRNA = NM_013767
| Mm_RefseqProtein = NP_038795
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 79245107
| Mm_GenLoc_end = 79266120
| Mm_Uniprot = Q8CBH9
}}
}}
'''Casein kinase 1, epsilon''', also known as '''CSNK1E''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: CSNK1E casein kinase 1, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1454| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FAS... {October 10, 2007 6:51:49 PM PDT}
- SEARCH REDIRECT: Control Box Found: Fas receptor {October 10, 2007 6:52:38 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Fas receptor. Invoking a Mandantory Inspection. {October 10, 2007 6:52:41 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FAS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ddf.
| PDB = {{PDB2|1ddf}}
| Name = Fas (TNF receptor superfamily, member 6)
| HGNCid = 11920
| Symbol = FAS
| AltSymbols =; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
| OMIM = 134637
| ECnumber =
| Homologene = 27
| MGIid = 95484
| GeneAtlas_image1 = PBB_GE_FAS_204780_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FAS_204781_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_FAS_215719_x_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 355
| Hs_Ensembl = ENSG00000026103
| Hs_RefseqProtein = NP_000034
| Hs_RefseqmRNA = NM_000043
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 90739206
| Hs_GenLoc_end = 90765521
| Hs_Uniprot = P25445
| Mm_EntrezGene = 14102
| Mm_Ensembl = ENSMUSG00000024778
| Mm_RefseqmRNA = NM_007987
| Mm_RefseqProtein = NP_032013
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 34356663
| Mm_GenLoc_end = 34393767
| Mm_Uniprot = Q6GT31
}}
}}
'''Fas (TNF receptor superfamily, member 6)''', also known as '''FAS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.<ref>{{cite web | title = Entrez Gene: FAS Fas (TNF receptor superfamily, member 6)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=355| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagata S |title=Apoptosis by death factor. |journal=Cell |volume=88 |issue= 3 |pages= 355-65 |year= 1997 |pmid= 9039262 |doi= }}
*{{cite journal | author=Cascino I, Papoff G, Eramo A, Ruberti G |title=Soluble Fas/Apo-1 splicing variants and apoptosis. |journal=Front. Biosci. |volume=1 |issue= |pages= d12-8 |year= 2004 |pmid= 9159204 |doi= }}
*{{cite journal | author=Uckun FM |title=Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. |journal=Biochem. Pharmacol. |volume=56 |issue= 6 |pages= 683-91 |year= 1998 |pmid= 9751072 |doi= }}
*{{cite journal | author=Krammer PH |title=CD95's deadly mission in the immune system. |journal=Nature |volume=407 |issue= 6805 |pages= 789-95 |year= 2000 |pmid= 11048730 |doi= 10.1038/35037728 }}
*{{cite journal | author=Siegel RM, Chan FK, Chun HJ, Lenardo MJ |title=The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. |journal=Nat. Immunol. |volume=1 |issue= 6 |pages= 469-74 |year= 2001 |pmid= 11101867 |doi= 10.1038/82712 }}
*{{cite journal | author=Wajant H |title=The Fas signaling pathway: more than a paradigm. |journal=Science |volume=296 |issue= 5573 |pages= 1635-6 |year= 2002 |pmid= 12040174 |doi= 10.1126/science.1071553 }}
*{{cite journal | author=Yonehara S |title=Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 393-402 |year= 2003 |pmid= 12220552 |doi= }}
*{{cite journal | author=Choi C, Benveniste EN |title=Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. |journal=Brain Res. Brain Res. Rev. |volume=44 |issue= 1 |pages= 65-81 |year= 2004 |pmid= 14739003 |doi= }}
*{{cite journal | author=Poppema S, Maggio E, van den Berg A |title=Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. |journal=Leuk. Lymphoma |volume=45 |issue= 3 |pages= 423-31 |year= 2004 |pmid= 15160902 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HBA1... {October 10, 2007 6:55:05 PM PDT}
- SEARCH: Multiple Conflicting Pages. Need Resolution. {October 10, 2007 6:55:25 PM PDT}
- AMBIGUITY: More than one potential page found for updating, HBA1 HBA1 {October 10, 2007 6:55:25 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a00}}, {{PDB2|1a01}}, {{PDB2|1a0u}}, {{PDB2|1a0z}}, {{PDB2|1a3n}}, {{PDB2|1a3o}}, {{PDB2|1a9w}}, {{PDB2|1abw}}, {{PDB2|1aby}}, {{PDB2|1aj9}}, {{PDB2|1b86}}, {{PDB2|1bab}}, {{PDB2|1bbb}}, {{PDB2|1bij}}, {{PDB2|1buw}}, {{PDB2|1bz0}}, {{PDB2|1bz1}}, {{PDB2|1bzz}}, {{PDB2|1c7b}}, {{PDB2|1c7c}}, {{PDB2|1c7d}}, {{PDB2|1cls}}, {{PDB2|1cmy}}, {{PDB2|1coh}}, {{PDB2|1dke}}, {{PDB2|1dxt}}, {{PDB2|1dxu}}, {{PDB2|1dxv}}, {{PDB2|1fdh}}, {{PDB2|1fn3}}, {{PDB2|1g9v}}, {{PDB2|1gbu}}, {{PDB2|1gbv}}, {{PDB2|1gli}}, {{PDB2|1gzx}}, {{PDB2|1hab}}, {{PDB2|1hac}}, {{PDB2|1hba}}, {{PDB2|1hbb}}, {{PDB2|1hbs}}, {{PDB2|1hco}}, {{PDB2|1hdb}}, {{PDB2|1hga}}, {{PDB2|1hgb}}, {{PDB2|1hgc}}, {{PDB2|1hho}}, {{PDB2|1ird}}, {{PDB2|1j3y}}, {{PDB2|1j3z}}, {{PDB2|1j40}}, {{PDB2|1j41}}, {{PDB2|1j7s}}, {{PDB2|1j7w}}, {{PDB2|1j7y}}, {{PDB2|1jy7}}, {{PDB2|1k0y}}, {{PDB2|1k1k}}, {{PDB2|1kd2}}, {{PDB2|1lfl}}, {{PDB2|1lfq}}, {{PDB2|1lft}}, {{PDB2|1lfv}}, {{PDB2|1lfy}}, {{PDB2|1lfz}}, {{PDB2|1ljw}}, {{PDB2|1m9p}}, {{PDB2|1mko}}, {{PDB2|1nej}}, {{PDB2|1nih}}, {{PDB2|1nqp}}, {{PDB2|1o1i}}, {{PDB2|1o1j}}, {{PDB2|1o1k}}, {{PDB2|1o1l}}, {{PDB2|1o1m}}, {{PDB2|1o1n}}, {{PDB2|1o1o}}, {{PDB2|1o1p}}, {{PDB2|1qi8}}, {{PDB2|1qsh}}, {{PDB2|1qsi}}, {{PDB2|1qxd}}, {{PDB2|1qxe}}, {{PDB2|1r1x}}, {{PDB2|1r1y}}, {{PDB2|1rps}}, {{PDB2|1rq3}}, {{PDB2|1rq4}}, {{PDB2|1rqa}}, {{PDB2|1rvw}}, {{PDB2|1sdk}}, {{PDB2|1sdl}}, {{PDB2|1shr}}, {{PDB2|1si4}}, {{PDB2|1thb}}, {{PDB2|1uiw}}, {{PDB2|1vwt}}, {{PDB2|1xxt}}, {{PDB2|1xy0}}, {{PDB2|1xye}}, {{PDB2|1xz2}}, {{PDB2|1xz4}}, {{PDB2|1xz5}}, {{PDB2|1xz7}}, {{PDB2|1xzu}}, {{PDB2|1xzv}}, {{PDB2|1y01}}, {{PDB2|1y09}}, {{PDB2|1y0a}}, {{PDB2|1y0c}}, {{PDB2|1y0d}}, {{PDB2|1y0t}}, {{PDB2|1y0w}}, {{PDB2|1y22}}, {{PDB2|1y2z}}, {{PDB2|1y31}}, {{PDB2|1y35}}, {{PDB2|1y45}}, {{PDB2|1y46}}, {{PDB2|1y4b}}, {{PDB2|1y4f}}, {{PDB2|1y4g}}, {{PDB2|1y4p}}, {{PDB2|1y4q}}, {{PDB2|1y4r}}, {{PDB2|1y4v}}, {{PDB2|1y5f}}, {{PDB2|1y5j}}, {{PDB2|1y5k}}, {{PDB2|1y7c}}, {{PDB2|1y7d}}, {{PDB2|1y7g}}, {{PDB2|1y7z}}, {{PDB2|1y83}}, {{PDB2|1y85}}, {{PDB2|1y8w}}, {{PDB2|1ydz}}, {{PDB2|1ye0}}, {{PDB2|1ye1}}, {{PDB2|1ye2}}, {{PDB2|1yen}}, {{PDB2|1yeo}}, {{PDB2|1yeq}}, {{PDB2|1yeu}}, {{PDB2|1yev}}, {{PDB2|1yff}}, {{PDB2|1yg5}}, {{PDB2|1ygd}}, {{PDB2|1ygf}}, {{PDB2|1yh9}}, {{PDB2|1yhe}}, {{PDB2|1yhr}}, {{PDB2|1yie}}, {{PDB2|1yih}}, {{PDB2|1yvq}}, {{PDB2|1yvt}}, {{PDB2|1yzi}}, {{PDB2|1z8u}}, {{PDB2|2d5z}}, {{PDB2|2d60}}, {{PDB2|2dn1}}, {{PDB2|2dn2}}, {{PDB2|2dn3}}, {{PDB2|2h35}}, {{PDB2|2hbc}}, {{PDB2|2hbd}}, {{PDB2|2hbe}}, {{PDB2|2hbf}}, {{PDB2|2hbs}}, {{PDB2|2hco}}, {{PDB2|2hhb}}, {{PDB2|2hhd}}, {{PDB2|2hhe}}, {{PDB2|3hhb}}, {{PDB2|4hhb}}, {{PDB2|6hbw}}
| Name = Hemoglobin, alpha 1
| HGNCid = 4823
| Symbol = HBA1
| AltSymbols =; CD31; MGC126895; MGC126897; HBA1
| OMIM = 141800
| ECnumber =
| Homologene = 469
| MGIid = 96015
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0005344 |text = oxygen transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005833 |text = hemoglobin complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015671 |text = oxygen transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3039
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000549
| Hs_RefseqmRNA = NM_000558
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 15122
| Mm_Ensembl = ENSMUSG00000069917
| Mm_RefseqmRNA = NM_008218
| Mm_RefseqProtein = NP_032244
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 32196489
| Mm_GenLoc_end = 32197310
| Mm_Uniprot = Q61287
}}
}}
'''Hemoglobin, alpha 1''', also known as '''HBA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.<ref>{{cite web | title = Entrez Gene: HBA1 hemoglobin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3039| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schillirò G, Russo-Mancuso G, Dibenedetto SP, ''et al.'' |title=Six rare hemoglobin variants found in Sicily. |journal=Hemoglobin |volume=15 |issue= 5 |pages= 431-7 |year= 1992 |pmid= 1802885 |doi= }}
*{{cite journal | author=Higgs DR, Vickers MA, Wilkie AO, ''et al.'' |title=A review of the molecular genetics of the human alpha-globin gene cluster. |journal=Blood |volume=73 |issue= 5 |pages= 1081-104 |year= 1989 |pmid= 2649166 |doi= }}
*{{cite journal | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165-96 |year= 1995 |pmid= 7555018 |doi= }}
*{{cite journal | author=Yalçin A, Avcu F, Beyan C, ''et al.'' |title=A case of HB J-Meerut (or Hb J-Birmingham) [alpha 120(H3)Ala-->Glu] |journal=Hemoglobin |volume=18 |issue= 6 |pages= 433-5 |year= 1995 |pmid= 7713747 |doi= }}
*{{cite journal | author=Turbpaiboon C, Svasti S, Sawangareetakul P, ''et al.'' |title=Hb Siam [alpha15(A13)Gly-->Arg (alpha1) (GGT-->CGT)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect. |journal=Hemoglobin |volume=26 |issue= 1 |pages= 77-81 |year= 2002 |pmid= 11939517 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MTHFR... {October 10, 2007 6:55:25 PM PDT}
- SEARCH REDIRECT: Control Box Found: Methylenetetrahydrofolate reductase {October 10, 2007 6:55:49 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Methylenetetrahydrofolate reductase. Invoking a Mandantory Inspection. {October 10, 2007 6:55:51 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5,10-methylenetetrahydrofolate reductase (NADPH)
| HGNCid = 7436
| Symbol = MTHFR
| AltSymbols =;
| OMIM = 607093
| ECnumber =
| Homologene = 4349
| MGIid = 106639
| GeneAtlas_image1 = PBB_GE_MTHFR_206800_at_tn.png
| GeneAtlas_image2 = PBB_GE_MTHFR_217071_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MTHFR_217070_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004489 |text = methylenetetrahydrofolate reductase (NADPH) activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006555 |text = methionine metabolic process}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0009086 |text = methionine biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4524
| Hs_Ensembl = ENSG00000177000
| Hs_RefseqProtein = NP_005948
| Hs_RefseqmRNA = NM_005957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 11768367
| Hs_GenLoc_end = 11788702
| Hs_Uniprot = P42898
| Mm_EntrezGene = 17769
| Mm_Ensembl = ENSMUSG00000029009
| Mm_RefseqmRNA = NM_010840
| Mm_RefseqProtein = NP_034970
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 146882883
| Mm_GenLoc_end = 146903353
| Mm_Uniprot = Q3V399
}}
}}
'''5,10-methylenetetrahydrofolate reductase (NADPH)''', also known as '''MTHFR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Methylenetetrahydrofolate reductase (EC 1.5.1.20) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: MTHFR 5,10-methylenetetrahydrofolate reductase (NADPH)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4524| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Matthews RG |title=Methylenetetrahydrofolate reductase: a common human polymorphism and its biochemical implications. |journal=Chemical record (New York, N.Y.) |volume=2 |issue= 1 |pages= 4-12 |year= 2003 |pmid= 11933257 |doi= }}
*{{cite journal | author=Schwahn B, Rozen R |title=Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. |journal=American journal of pharmacogenomics : genomics-related research in drug development and clinical practice |volume=1 |issue= 3 |pages= 189-201 |year= 2002 |pmid= 12083967 |doi= }}
*{{cite journal | author=Iqbal MP, Frossard PM |title=Methylene tetrahydrofolate reductase gene and coronary artery disease. |journal=JPMA. The Journal of the Pakistan Medical Association |volume=53 |issue= 1 |pages= 33-6 |year= 2003 |pmid= 12666851 |doi= }}
*{{cite journal | author=Bailey LB |title=Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. |journal=J. Nutr. |volume=133 |issue= 11 Suppl 1 |pages= 3748S-3753S |year= 2003 |pmid= 14608109 |doi= }}
*{{cite journal | author=Wiwanitkit V |title=Roles of methylenetetrahydrofolate reductase C677T polymorphism in repeated pregnancy loss. |journal=Clin. Appl. Thromb. Hemost. |volume=11 |issue= 3 |pages= 343-5 |year= 2005 |pmid= 16015422 |doi= }}
*{{cite journal | author=Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M |title=Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 2 |pages= 143-9 |year= 2006 |pmid= 16172608 |doi= 10.1038/sj.mp.4001746 }}
*{{cite journal | author=Lewis SJ, Lawlor DA, Davey Smith G, ''et al.'' |title=The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 4 |pages= 352-60 |year= 2006 |pmid= 16402130 |doi= 10.1038/sj.mp.4001790 }}
*{{cite journal | author=Pereira TV, Rudnicki M, Pereira AC, ''et al.'' |title=5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 10 |pages= 1956-63 |year= 2007 |pmid= 17035405 |doi= 10.1158/1055-9965.EPI-06-0334 }}
*{{cite journal | author=Leclerc D, Rozen R |title=[Molecular genetics of MTHFR: polymorphisms are not all benign] |journal=Med Sci (Paris) |volume=23 |issue= 3 |pages= 297-302 |year= 2007 |pmid= 17349292 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1D2... {October 10, 2007 6:59:24 PM PDT}
- SEARCH REDIRECT: Control Box Found: NR1D2 {October 10, 2007 6:59:49 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=NR1D2>NR1D2</a> {October 10, 2007 6:59:57 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: NR1D2. Invoking a Mandantory Inspection. {October 10, 2007 7:00:04 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1D2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a6y.
| PDB = {{PDB2|1a6y}}, {{PDB2|1ga5}}, {{PDB2|1hlz}}
| Name = Nuclear receptor subfamily 1, group D, member 2
| HGNCid = 7963
| Symbol = NR1D2
| AltSymbols =; HZF2; BD73; EAR-1r; Hs.37288; RVR
| OMIM = 602304
| ECnumber =
| Homologene = 3763
| MGIid = 2449205
| GeneAtlas_image1 = PBB_GE_NR1D2_209750_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9975
| Hs_Ensembl = ENSG00000174738
| Hs_RefseqProtein = XP_001130839
| Hs_RefseqmRNA = XM_001130839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 23961810
| Hs_GenLoc_end = 23996240
| Hs_Uniprot = Q14995
| Mm_EntrezGene = 353187
| Mm_Ensembl = ENSMUSG00000021775
| Mm_RefseqmRNA = NM_011584
| Mm_RefseqProtein = NP_035714
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 16997124
| Mm_GenLoc_end = 17032066
| Mm_Uniprot = Q4VAB7
}}
}}
'''Nuclear receptor subfamily 1, group D, member 2''', also known as '''NR1D2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PER1... {October 10, 2007 6:55:51 PM PDT}
- SEARCH REDIRECT: Control Box Found: PER1 {October 10, 2007 6:56:09 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: PER1. Invoking a Mandantory Inspection. {October 10, 2007 6:56:12 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Period homolog 1 (Drosophila)
| HGNCid = 8845
| Symbol = PER1
| AltSymbols =; MGC88021; PER; RIGUI; hPER
| OMIM = 602260
| ECnumber =
| Homologene = 1966
| MGIid = 1098283
| GeneAtlas_image1 = PBB_GE_PER1_36829_at_tn.png
| GeneAtlas_image2 = PBB_GE_PER1_202861_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009649 |text = entrainment of circadian clock}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5187
| Hs_Ensembl = ENSG00000179094
| Hs_RefseqProtein = NP_002607
| Hs_RefseqmRNA = NM_002616
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 7984534
| Hs_GenLoc_end = 7996427
| Hs_Uniprot = O15534
| Mm_EntrezGene = 18626
| Mm_Ensembl = ENSMUSG00000020893
| Mm_RefseqmRNA = NM_011065
| Mm_RefseqProtein = NP_035195
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 68915129
| Mm_GenLoc_end = 68926158
| Mm_Uniprot = Q3U378
}}
}}
'''Period homolog 1 (Drosophila)''', also known as '''PER1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.<ref>{{cite web | title = Entrez Gene: PER1 period homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5187| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTEN... {October 10, 2007 6:56:12 PM PDT}
- SEARCH REDIRECT: Control Box Found: PTEN (gene) {October 10, 2007 6:56:39 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=PTEN (gene)>PTEN (gene)</a> {October 10, 2007 6:56:47 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: PTEN (gene). Invoking a Mandantory Inspection. {October 10, 2007 6:56:55 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTEN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d5r.
| PDB = {{PDB2|1d5r}}
| Name = Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
| HGNCid = 9588
| Symbol = PTEN
| AltSymbols =; BZS; MGC11227; MHAM; MMAC1; PTEN1; TEP1
| OMIM = 601728
| ECnumber =
| Homologene = 265
| MGIid = 109583
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004438 |text = phosphatidylinositol-3-phosphatase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008138 |text = protein tyrosine/serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016314 |text = phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0051717 |text = inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity}} {{GNF_GO|id=GO:0051800 |text = phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0031647 |text = regulation of protein stability}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0046855 |text = inositol phosphate dephosphorylation}} {{GNF_GO|id=GO:0046856 |text = phosphoinositide dephosphorylation}} {{GNF_GO|id=GO:0051895 |text = negative regulation of focal adhesion formation}} {{GNF_GO|id=GO:0051898 |text = negative regulation of protein kinase B signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5728
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000305
| Hs_RefseqmRNA = NM_000314
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 19211
| Mm_Ensembl = ENSMUSG00000013663
| Mm_RefseqmRNA = NM_008960
| Mm_RefseqProtein = NP_032986
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 32823574
| Mm_GenLoc_end = 32892157
| Mm_Uniprot = Q3UFB0
}}
}}
'''Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)''', also known as '''PTEN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.<ref>{{cite web | title = Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5728| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Waite KA, Eng C |title=Protean PTEN: form and function. |journal=Am. J. Hum. Genet. |volume=70 |issue= 4 |pages= 829-44 |year= 2002 |pmid= 11875759 |doi= }}
*{{cite journal | author=Knobbe CB, Merlo A, Reifenberger G |title=Pten signaling in gliomas. |journal=Neuro-oncology |volume=4 |issue= 3 |pages= 196-211 |year= 2002 |pmid= 12084351 |doi= }}
*{{cite journal | author=Eng C |title=Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis. |journal=Ann. N. Y. Acad. Sci. |volume=968 |issue= |pages= 213-21 |year= 2002 |pmid= 12119278 |doi= }}
*{{cite journal | author=Backman S, Stambolic V, Mak T |title=PTEN function in mammalian cell size regulation. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 5 |pages= 516-22 |year= 2002 |pmid= 12367630 |doi= }}
*{{cite journal | author=Wishart MJ, Dixon JE |title=PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. |journal=Trends Cell Biol. |volume=12 |issue= 12 |pages= 579-85 |year= 2003 |pmid= 12495846 |doi= }}
*{{cite journal | author=Deocampo ND, Huang H, Tindall DJ |title=The role of PTEN in the progression and survival of prostate cancer. |journal=Minerva Endocrinol. |volume=28 |issue= 2 |pages= 145-53 |year= 2003 |pmid= 12717346 |doi= }}
*{{cite journal | author=Downes CP, Walker S, McConnachie G, ''et al.'' |title=Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 338-42 |year= 2004 |pmid= 15046604 |doi= 10.1042/ }}
*{{cite journal | author=Maehama T, Okahara F, Kanaho Y |title=The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 343-7 |year= 2004 |pmid= 15046605 |doi= 10.1042/ }}
*{{cite journal | author=Parsons R |title=Human cancer, PTEN and the PI-3 kinase pathway. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 2 |pages= 171-6 |year= 2004 |pmid= 15209376 |doi= }}
*{{cite journal | author=Steelman LS, Bertrand FE, McCubrey JA |title=The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. |journal=Expert Opin. Ther. Targets |volume=8 |issue= 6 |pages= 537-50 |year= 2005 |pmid= 15584861 |doi= 10.1517/14728222.8.6.537 }}
*{{cite journal | author=Mulholland DJ, Dedhar S, Wu H, Nelson CC |title=PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. |journal=Oncogene |volume=25 |issue= 3 |pages= 329-37 |year= 2006 |pmid= 16421604 |doi= 10.1038/sj.onc.1209020 }}
*{{cite journal | author=Vazquez F, Devreotes P |title=Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1523-7 |year= 2006 |pmid= 16861931 |doi= }}
*{{cite journal | author=Mellinghoff IK, Cloughesy TF, Mischel PS |title=PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. |journal=Clin. Cancer Res. |volume=13 |issue= 2 Pt 1 |pages= 378-81 |year= 2007 |pmid= 17255257 |doi= 10.1158/1078-0432.CCR-06-1992 }}
*{{cite journal | author=Shen MM, Abate-Shen C |title=Pten inactivation and the emergence of androgen-independent prostate cancer. |journal=Cancer Res. |volume=67 |issue= 14 |pages= 6535-8 |year= 2007 |pmid= 17638861 |doi= 10.1158/0008-5472.CAN-07-1271 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SNCA... {October 10, 2007 6:56:55 PM PDT}
- SEARCH REDIRECT: Control Box Found: Alpha-synuclein {October 10, 2007 6:57:24 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Alpha-synuclein>Alpha-synuclein</a> {October 10, 2007 6:57:32 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Alpha-synuclein. Invoking a Mandantory Inspection. {October 10, 2007 6:57:39 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SNCA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xq8.
| PDB = {{PDB2|1xq8}}
| Name = Synuclein, alpha (non A4 component of amyloid precursor)
| HGNCid = 11138
| Symbol = SNCA
| AltSymbols =; PD1; MGC110988; NACP; PARK1; PARK4
| OMIM = 163890
| ECnumber =
| Homologene = 293
| MGIid = 1277151
| GeneAtlas_image1 = PBB_GE_SNCA_204466_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SNCA_204467_s_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0019717 |text = synaptosome}}
| Process = {{GNF_GO|id=GO:0001956 |text = positive regulation of neurotransmitter secretion}} {{GNF_GO|id=GO:0001963 |text = synaptic transmission, dopaminergic}} {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0040012 |text = regulation of locomotion}} {{GNF_GO|id=GO:0042416 |text = dopamine biosynthetic process}} {{GNF_GO|id=GO:0042493 |text = response to drug}} {{GNF_GO|id=GO:0048169 |text = regulation of long-term neuronal synaptic plasticity}} {{GNF_GO|id=GO:0048489 |text = synaptic vesicle transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6622
| Hs_Ensembl = ENSG00000145335
| Hs_RefseqProtein = NP_000336
| Hs_RefseqmRNA = NM_000345
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 90866479
| Hs_GenLoc_end = 90978470
| Hs_Uniprot = P37840
| Mm_EntrezGene = 20617
| Mm_Ensembl = ENSMUSG00000025889
| Mm_RefseqmRNA = NM_001042451
| Mm_RefseqProtein = NP_001035916
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 60661224
| Mm_GenLoc_end = 60759433
| Mm_Uniprot = Q3U130
}}
}}
'''Synuclein, alpha (non A4 component of amyloid precursor)''', also known as '''SNCA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.<ref>{{cite web | title = Entrez Gene: SNCA synuclein, alpha (non A4 component of amyloid precursor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6622| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lavedan C |title=The synuclein family. |journal=Genome Res. |volume=8 |issue= 9 |pages= 871-80 |year= 1998 |pmid= 9750188 |doi= }}
*{{cite journal | author=Ozawa T, Wakabayashi K, Oyanagi K |title=[Recent progress in the research of multiple system atrophy with special references to alpha-synuclein and suprachiasmatic nucleus] |journal=No To Shinkei |volume=54 |issue= 2 |pages= 111-7 |year= 2002 |pmid= 11889756 |doi= }}
*{{cite journal | author=Cole NB, Murphy DD |title=The cell biology of alpha-synuclein: a sticky problem? |journal=Neuromolecular Med. |volume=1 |issue= 2 |pages= 95-109 |year= 2002 |pmid= 12025860 |doi= }}
*{{cite journal | author=Iwatsubo T |title=[alpha-synuclein and Parkinson's disease] |journal=Seikagaku |volume=74 |issue= 6 |pages= 477-82 |year= 2002 |pmid= 12138709 |doi= }}
*{{cite journal | author=Trojanowski JQ, Lee VM |title=Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses. |journal=Neurotoxicology |volume=23 |issue= 4-5 |pages= 457-60 |year= 2002 |pmid= 12428717 |doi= }}
*{{cite journal | author=Alves da Costa C |title=Recent advances on alpha-synuclein cell biology: functions and dysfunctions. |journal=Curr. Mol. Med. |volume=3 |issue= 1 |pages= 17-24 |year= 2003 |pmid= 12558071 |doi= }}
*{{cite journal | author=Di Rosa G, Puzzo D, Sant'Angelo A, ''et al.'' |title=Alpha-synuclein: between synaptic function and dysfunction. |journal=Histol. Histopathol. |volume=18 |issue= 4 |pages= 1257-66 |year= 2004 |pmid= 12973692 |doi= }}
*{{cite journal | author=Baptista MJ, Cookson MR, Miller DW |title=Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 1 |pages= 63-72 |year= 2004 |pmid= 14987449 |doi= 10.1177/1073858403260392 }}
*{{cite journal | author=Kim S, Seo JH, Suh YH |title=Alpha-synuclein, Parkinson's disease, and Alzheimer's disease. |journal=Parkinsonism Relat. Disord. |volume=10 Suppl 1 |issue= |pages= S9-13 |year= 2004 |pmid= 15109581 |doi= 10.1016/j.parkreldis.2003.11.005 }}
*{{cite journal | author=Sidhu A, Wersinger C, Vernier P |title=alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. |journal=FEBS Lett. |volume=565 |issue= 1-3 |pages= 1-5 |year= 2004 |pmid= 15135042 |doi= 10.1016/j.febslet.2004.03.063 }}
*{{cite journal | author=Vekrellis K, Rideout HJ, Stefanis L |title=Neurobiology of alpha-synuclein. |journal=Mol. Neurobiol. |volume=30 |issue= 1 |pages= 1-21 |year= 2004 |pmid= 15247485 |doi= }}
*{{cite journal | author=Chiba-Falek O, Nussbaum RL |title=Regulation of alpha-synuclein expression: implications for Parkinson's disease. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=68 |issue= |pages= 409-15 |year= 2004 |pmid= 15338643 |doi= }}
*{{cite journal | author=Pankratz N, Foroud T |title=Genetics of Parkinson disease. |journal=NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics |volume=1 |issue= 2 |pages= 235-42 |year= 2005 |pmid= 15717024 |doi= }}
*{{cite journal | author=Singleton AB |title=Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin. |journal=Trends Neurosci. |volume=28 |issue= 8 |pages= 416-21 |year= 2005 |pmid= 15955578 |doi= 10.1016/j.tins.2005.05.009 }}
*{{cite journal | author=Lee HG, Zhu X, Takeda A, ''et al.'' |title=Emerging evidence for the neuroprotective role of alpha-synuclein. |journal=Exp. Neurol. |volume=200 |issue= 1 |pages= 1-7 |year= 2006 |pmid= 16780837 |doi= 10.1016/j.expneurol.2006.04.024 }}
*{{cite journal | author=Giorgi FS, Bandettini di Poggio A, Battaglia G, ''et al.'' |title=A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinson's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 70 |pages= 105-9 |year= 2006 |pmid= 17017516 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SP1... {October 10, 2007 6:57:39 PM PDT}
- SEARCH REDIRECT: Control Box Found: Sp1 {October 10, 2007 6:58:06 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Sp1>Sp1</a> {October 10, 2007 6:58:13 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Sp1. Invoking a Mandantory Inspection. {October 10, 2007 6:58:21 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1sp1.
| PDB = {{PDB2|1sp1}}, {{PDB2|1sp2}}, {{PDB2|1va1}}, {{PDB2|1va2}}, {{PDB2|1va3}}
| Name = Sp1 transcription factor
| HGNCid = 11205
| Symbol = SP1
| AltSymbols =;
| OMIM = 189906
| ECnumber =
| Homologene = 8276
| MGIid = 98372
| GeneAtlas_image1 = PBB_GE_SP1_214732_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045817 |text = positive regulation of global transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6667
| Hs_Ensembl = ENSG00000185591
| Hs_RefseqProtein = NP_612482
| Hs_RefseqmRNA = NM_138473
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 52060246
| Hs_GenLoc_end = 52096488
| Hs_Uniprot = P08047
| Mm_EntrezGene = 20683
| Mm_Ensembl = ENSMUSG00000001280
| Mm_RefseqmRNA = NM_013672
| Mm_RefseqProtein = NP_038700
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 102234414
| Mm_GenLoc_end = 102260419
| Mm_Uniprot = O89090
}}
}}
'''Sp1 transcription factor''', also known as '''SP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tseng L, Gao J, Mazella J, ''et al.'' |title=Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium. |journal=Ann. N. Y. Acad. Sci. |volume=828 |issue= |pages= 27-37 |year= 1997 |pmid= 9329821 |doi= }}
*{{cite journal | author=Dyson N |title=The regulation of E2F by pRB-family proteins. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2245-62 |year= 1998 |pmid= 9694791 |doi= }}
*{{cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401-14 |year= 2003 |pmid= 12943729 |doi= }}
*{{cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal | author=Seelamgari A, Maddukuri A, Berro R, ''et al.'' |title=Role of viral regulatory and accessory proteins in HIV-1 replication. |journal=Front. Biosci. |volume=9 |issue= |pages= 2388-413 |year= 2006 |pmid= 15353294 |doi= }}
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on STAT3... {October 10, 2007 6:58:21 PM PDT}
- SEARCH REDIRECT: Control Box Found: STAT3 {October 10, 2007 6:58:48 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: STAT3. Invoking a Mandantory Inspection. {October 10, 2007 6:58:50 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_STAT3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bg1.
| PDB = {{PDB2|1bg1}}
| Name = Signal transducer and activator of transcription 3 (acute-phase response factor)
| HGNCid = 11364
| Symbol = STAT3
| AltSymbols =; APRF; FLJ20882; MGC16063
| OMIM = 102582
| ECnumber =
| Homologene = 7960
| MGIid = 103038
| GeneAtlas_image1 = PBB_GE_STAT3_208991_at_tn.png
| GeneAtlas_image2 = PBB_GE_STAT3_208992_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STAT3_gnf1h01250_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005062 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6774
| Hs_Ensembl = ENSG00000168610
| Hs_RefseqProtein = NP_003141
| Hs_RefseqmRNA = NM_003150
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 37718869
| Hs_GenLoc_end = 37794039
| Hs_Uniprot = P40763
| Mm_EntrezGene = 20848
| Mm_Ensembl = ENSMUSG00000004040
| Mm_RefseqmRNA = XM_001005155
| Mm_RefseqProtein = XP_001005155
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 100701188
| Mm_GenLoc_end = 100755630
| Mm_Uniprot = Q8CFJ6
}}
}}
'''Signal transducer and activator of transcription 3 (acute-phase response factor)''', also known as '''STAT3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.<ref>{{cite web | title = Entrez Gene: STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6774| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoey T, Grusby MJ |title=STATs as mediators of cytokine-induced responses. |journal=Adv. Immunol. |volume=71 |issue= |pages= 145-62 |year= 1999 |pmid= 9917912 |doi= }}
*{{cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1-24 |year= 2002 |pmid= 12039028 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Inghirami G, Chiarle R, Simmons WJ, ''et al.'' |title=New and old functions of STAT3: a pivotal target for individualized treatment of cancer. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1131-3 |year= 2006 |pmid= 16082218 |doi= }}
*{{cite journal | author=Leeman RJ, Lui VW, Grandis JR |title=STAT3 as a therapeutic target in head and neck cancer. |journal=Expert opinion on biological therapy |volume=6 |issue= 3 |pages= 231-41 |year= 2006 |pmid= 16503733 |doi= 10.1517/14712598.6.3.231 }}
*{{cite journal | author=Aggarwal BB, Sethi G, Ahn KS, ''et al.'' |title=Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. |journal=Ann. N. Y. Acad. Sci. |volume=1091 |issue= |pages= 151-69 |year= 2007 |pmid= 17341611 |doi= 10.1196/annals.1378.063 }}
}}
{{refend}}
{{protein-stub}}
end log.
