Vascular organ of lamina terminalis

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Vascular organ of lamina terminalis
Details
Identifiers
Latin organum vasculosum laminae terminalis
NeuroNames 383
NeuroLex ID nlx_anat_100313
TA A14.1.08.940
FMA 62315
Anatomical terms of neuroanatomy

The vascular organ of lamina terminalis (VOLT), organum vasculosum of the lamina terminalis (OVLT), or supraoptic crest[1] is one of the four sensory circumventricular organs of the brain, the others being the subfornical organ, the median eminence, and the area postrema in the brainstem.[2]

Anteroventral third ventricle region[edit]

The OVLT, median eminence, and subfornical organ are interconnected with the mid-ventral hypothalamus, and together these three structures surround the third ventricle, a complex often called the "AV3V" region.[2][3][4] This region functions in the regulation of fluid and electrolyte balance by controlling thirst, sodium excretion, blood volume regulation, and vasopressin secretion.[3][5]

Function[edit]

The OVLT is one of the four sensory circumventricular organs providing information to other brain regions (others are median eminence, subfornical organ, and area postrema).[2][6][7]

OVLT capillaries do not have a blood-brain barrier, and so neurons in this region can respond to circulating factors present in the systemic circulation.[2][5]

Neurons in the OVLT are osmoreceptors sensitive to the sodium content and osmotic pressure of blood.[3] Neurons of the lamina terminalis project to the supraoptic nucleus and paraventricular nucleus to regulate the activity of vasopressin-secreting neurons.[5] In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates receptors in the OVLT and subfornical organ to complete a positive feedback loop.[5][8][9] These neurons also project to the median preoptic nucleus which is involved in controlling thirst.[2][5][8]

References[edit]

  1. ^ "Organum vasculosum". BrainInfo, University of Washington, Seattle. 
  2. ^ a b c d e Gross, P. M; Weindl, A (1987). "Peering through the windows of the brain (review)". Journal of Cerebral Blood Flow & Metabolism. 7 (6): 663–72. doi:10.1038/jcbfm.1987.120. PMID 2891718. 
  3. ^ a b c Johnson, A. K (1985). "The periventricular anteroventral third ventricle (AV3V): Its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis". Brain research bulletin. 15 (6): 595–601. PMID 3910170. 
  4. ^ Miyata, S (2015). "New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains". Frontiers in Neuroscience. 9: 390. doi:10.3389/fnins.2015.00390. PMC 4621430Freely accessible. PMID 26578857. 
  5. ^ a b c d e Johnson, A. K; Gross, P. M (1993). "Sensory circumventricular organs and brain homeostatic pathways". FASEB journal : Official publication of the Federation of American Societies for Experimental Biology. 7 (8): 678–86. PMID 8500693. 
  6. ^ Shaver, S. W; Pang, J. J; Wainman, D. S; Wall, K. M; Gross, P. M (1992). "Morphology and function of capillary networks in subregions of the rat tuber cinereum". Cell and Tissue Research. 267 (3): 437–48. doi:10.1007/bf00319366. PMID 1571958. 
  7. ^ Fry Mark, Ferguson Alastair V., (2007) The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior, Physiology & Behavior, Volume 91, Issue 4, 24 July 2007, Pages 413-423, ISSN 0031-9384, doi:10.1016/j.physbeh.2007.04.003.
  8. ^ a b McKinley, M. J; Allen, A. M; May, C. N; McAllen, R. M; Oldfield, B. J; Sly, D; Mendelsohn, F. A (2001). "Neural pathways from the lamina terminalis influencing cardiovascular and body fluid homeostasis". Clinical and Experimental Pharmacology and Physiology. 28 (12): 990–2. PMID 11903300. 
  9. ^ Fitzgerald, M J Turlough (2012). Clinical Neuroanatomy and Neuroscience. Philadelphia: Saunders Elsevier. p. 281. ISBN 978-0-7020-3738-2.