Vasoplegic syndrome

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Vasoplegic syndrome (VPS) is a postperfusion syndrome characterized by low systemic vascular resistance and a high cardiac output.


Vasoplegic syndrome is defined as low systemic vascular resistance (SVR index <1,600 dyn∙sec/cm5/m2) and high cardiac output (cardiac index >2.5 l/min/m2) within the first 4 postoperative hours.[1]


VPS occurs more frequently after on pump CABG surgery versus off pump CABG surgery.[2] Hypothermia during surgery may also increase ones risk of developing VPS post operatively.[3]


There is some evidence to support the use of methylene blue in the treatment of this condition. Dose 0.5mg/kg on cardiopulmonary bypass.[4][5]


One case series reports a rate of 1 in 120 cases.[6]


  1. ^ "Critical Care | Full text | Vasoplegic syndrome after cardiopulmonary bypass surgery – associated factors and clinical outcomes: a nested case-control study". 
  2. ^ Sun X, Zhang L, Hill PC, et al. (October 2008). "Is incidence of postoperative vasoplegic syndrome different between off-pump and on-pump coronary artery bypass grafting surgery?". Eur J Cardiothorac Surg. 34 (4): 820–5. PMID 18715792. doi:10.1016/j.ejcts.2008.07.012. 
  3. ^ Xu J, Long C, Qi R, Xie L, Shi S, Zhang Y (January 2002). "[Study of mechanism of vasoplegic syndrome for open heart surgery]". Zhonghua Yi Xue Za Zhi (in Chinese). 82 (2): 127–30. PMID 11953144. 
  4. ^ "BestBets: Is Methylene Blue of benefit in treating adult patients who develop vasoplegic syndrome during Cardiac Surgery". 
  5. ^ Stawicki SP, Sims C, Sarani B, Grossman MD, Gracias VH (May 2008). "Methylene blue and vasoplegia: who, when, and how?". Mini Rev Med Chem. 8 (5): 472–90. PMID 18473936. doi:10.2174/138955708784223477. 
  6. ^ Gomes WJ, Carvalho AC, Palma JH, Gonçalves Júnior I, Buffolo E (1994). "[Vasoplegic syndrome: a new dilemma]". Rev Assoc Med Bras. 40 (4): 304. PMID 7633508.