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Lovastatin nonaketide synthase

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lovastatin nonaketide synthase
Identifiers
EC no.2.3.1.161
CAS no.235426-97-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, lovastatin nonaketide synthase (EC 2.3.1.161) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H+, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO2, NADP+, S-adenosyl-L-homocysteine, and H2O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

References

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  • Heever JP, Hutchinson CR, Vederas JC (2000). "Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue". J. Am. Chem. Soc. 122 (46): 11519–11520. doi:10.1021/ja003216.