Avanafil

Avanafil

Systematic (IUPAC) name
4-[(3-Chloro-4-methoxybenzyl)amino]-2-
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	330784-47-9 Y
ATC code	None
PubChem	CID 9869929
ChemSpider	8045620 Y
UNII	DR5S136IVO Y
KEGG	D03217 Y
Chemical data
Formula	C23H26ClN7O3
Mol. mass	483.951 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1 Y Key:WEAJZXNPAWBCOA-INIZCTEOSA-N Y
Y (what is this?)  (verify)

Avanafil is a PDE5 inhibitor being developed for erectile dysfunction. Avanafil currently has no trademarked term associated with it but it is being developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil.

Synthesis

Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative:

See also

• Viagra
• Cialis
• Levitra

Further reading

• Faster-Working Erectile Dysfunction Drug? cbsnews.com Nov 25th 2009
• Vivus says men taking avanafil were more likely to be ready for sex within 15 minutes taragana.com business news Jan 11th 2010
• New Avanafil Works In 15 minutes Compared To Cialis And Viagra Taking 30 June 28th 2011