Mesembrenone

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Mesembrenone
Mesembrenone2DACS.svg
Mesembrenone3Dan.gif
Identifiers
CAS number 468-54-2 N
PubChem 216272
ChemSpider 187467 N
Jmol-3D images Image 1
Properties
Molecular formula C17H21NO3
Molar mass 287.35 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Mesembrenone is an alkaloid constituent of Sceletium tortuosum (Kanna). Similar to modern synthetic antidepressants, it is a potent (IC50 < 1 μM) selective inhibitor of the serotonin transporter (SERT) (that is, a selective serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).[1]

See also[edit]

  • Mesembrine another alkaloid constituent of Kanna.

References[edit]

  1. ^ Harvey, A. L.; Young, L. C.; Viljoen, A. M.; Gericke, N. P. (October 2011). "Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids". Journal of Ethnopharmacology 137 (3): 1124–1129. doi:10.1016/j.jep.2011.07.035. PMID 21798331.