Blanc chloromethylation

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The Blanc chloromethylation is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride catalyzed by zinc chloride to form chloromethyl arenes.[1][2][3] The reaction should be performed with care, as (like most chloromethylation reactions) it produces highly carcinogenic bis(chloromethyl) ether as a by-product.

The Blanc chloromethylation
Mechanism of Blanc chloromethylation

See also[edit]


  1. ^ Gustave Louis Blanc Bull. Soc. Chim. France 1923, 33, 313
  2. ^ Whitmore, F. C.; Ginsburg, Abram; Rueggeberg, Walter; Tharp, I.; Nottorf, H.; Cannon, M.; Carnahan, F.; Cryder, D.; FLeming, G.; Goldberg, G.; Haggard, H.; Herr, C.; Hoover, T.; Lovell, H.; Mraz, R.; Noll, C.; Oakwood, T.; Patterson, H.; Van Strien, R.; Walter, R.; Zook, H.; Wagner, R.; Weisgerber, C.; Wilkins, J. (May 1946). "Production of Benzyl Chloride by Chloromethylation of Benzene. Laboratory and Pilot Plant Studies". Industrial & Engineering Chemistry 38 (5): 478–485. doi:10.1021/ie50437a013. 
  3. ^ Belen'kii, Leonid I; Vol'kenshtein, Yu B; Karmanova, I B (30 September 1977). "New Data on the Chloromethylation of Aromatic and Heteroaromatic Compounds". Russian Chemical Reviews 46 (9): 891–903. doi:10.1070/RC1977v046n09ABEH002180.