Blanc chloromethylation

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The Blanc chloromethylation is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride catalyzed by zinc chloride to form chloromethyl arenes.[1][2]. The reaction should be performed with care, as (like most chloromethylation reactions) it produces highly carcinogenic bis(chloromethyl) ether as a by-product.

The Blanc chloromethylation


Mechanism of Blanc chloromethylation


  1. ^ Gustave Louis Blanc Bull. Soc. Chim. France 1923, 33, 313.
  2. ^ Fuson, R. C.; McKeever, C. H. Org. React. 1942, 1, 63. (Review)

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