FMO4

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Flavin containing monooxygenase 4
Identifiers
Symbols FMO4 ; FMO2
External IDs OMIM136131 MGI2429497 HomoloGene68219 GeneCards: FMO4 Gene
EC number 1.14.13.8
RNA expression pattern
PBB GE FMO4 206263 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2329 226564
Ensembl ENSG00000076258 ENSMUSG00000026692
UniProt P31512 Q8VHG0
RefSeq (mRNA) NM_002022 NM_144878
RefSeq (protein) NP_002013 NP_659127
Location (UCSC) Chr 1:
171.28 – 171.31 Mb
Chr 1:
162.79 – 162.81 Mb
PubMed search [1] [2]

Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme that in humans is encoded by the FMO4 gene.[1][2]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.[2]

References[edit]

  1. ^ Lawton MP, Cashman JR, Cresteil T, Dolphin CT, Elfarra AA, Hines RN, Hodgson E, Kimura T, Ozols J (Mar 1994). "A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities". Arch Biochem Biophys 308 (1): 254–7. doi:10.1006/abbi.1994.1035. PMID 8311461. 
  2. ^ a b "Entrez Gene: FMO4 flavin containing monooxygenase 4". 

Further reading[edit]