Kahweol

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Kahweol
Kahweol.svg
Names
IUPAC name
(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol
Identifiers
6894-43-5 YesY
ChemSpider 102755 YesY
Jmol-3D images Image
PubChem 114778
Properties
C20H26O3
Molar mass 314.42 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Kahweol is a diterpene molecule found in the beans of Coffea arabica. It is structurally related to cafestol.

Recent research suggests that kahweol may have beneficial effects on bone by inhibiting osteoclast differentiation.[1] Another recent study confirmed that kahweol has anti-inflammatory and anti-angiogenic effects, offering a possible mechanism for the association found in epidemiological studies between consumption of unfiltered coffee and decreased risk of cancer.[2]

References[edit]

  1. ^ Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T (Mar 2012). "The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation.". J Pharmacol Sci 23 (4): 479–86. doi:10.1254/jphs.11212FP. PMID 22447306. 
  2. ^ Cárdenas C, Quesada AR, Medina MA (Aug 2011). "Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene.". PLoS ONE 6 (8): e23407. doi:10.1371/annotation/38262cc6-07cc-4074-8ce7-2181d4d0fbdc. PMC 3153489. PMID 21858104.  open access publication - free to read