Kahweol

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Kahweol
Kahweol.svg
Identifiers
CAS number 6894-43-5 YesY
PubChem 114778
ChemSpider 102755 YesY
Jmol-3D images Image 1
Properties
Molecular formula C20H26O3
Molar mass 314.42 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Kahweol is a diterpene molecule found in the beans of Coffea arabica. It is structurally related to cafestol.

Recent research suggests that kahweol may have beneficial effects on bone by inhibiting osteoclast differentiation.[1] Another recent study confirmed that kahweol has anti-inflammatory and anti-angiogenic effects, offering a possible mechanism for the association found in epidemiological studies between consumption of unfiltered coffee and decreased risk of cancer.[2]

References[edit]

  1. ^ Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T (Mar 2012). "The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation.". J Pharmacol Sci 23. doi:10.1254/jphs.11212FP. PMID 22447306. 
  2. ^ Cárdenas C, Quesada AR, Medina MA (Aug 2011). "Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene.". PLoS ONE 6. doi:10.1371/annotation/38262cc6-07cc-4074-8ce7-2181d4d0fbdc. PMID 21858104.