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|Look up mainframe in Wiktionary, the free dictionary.|
Mainframe may refer to any of the following:
- Mainframe computer, large and powerful data processing systems
- Mainframe Entertainment, a Canadian computer animation and design company
- Mainframe is the name of two fictional characters from Marvel Comics:
- Mainframe (Transformers) is an Autobot character in the Transformers series
- Mainframe (G.I. Joe), a fictional character in the G.I. Joe universe
- A character from the game Gunman Chronicles
- Mainframe is the city in which the CGI cartoon ReBoot takes place
- A "character", mostly offstage, in Gene Wolfe's The Book of the Long Sun
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