Metisazone

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Metisazone
Methisazone.png
Names
IUPAC name
[(1-Methyl-2-oxoindol-3-ylidene)amino]thiourea
Other names
Metisazone
Identifiers
ATC code J05AA01
CAS number 1910-68-5 YesY
ChEMBL ChEMBL1512080 N
ChemSpider 5259074
EC number 217-616-2
Jmol-3D images Image
KEGG D02496
MeSH D008720
PubChem 6861563
UNII K3QML4J07E N
Properties
C10H10N4OS
Molar mass 234.28 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Methisazone (USAN) or metisazone (INN) is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. It has been used in the past to treat smallpox.[1]

Methisazone has been described as being used in prophylaxis since at least 1965.[2][3]

References[edit]

  1. ^ Methisazone, Merriam-Webster's Medical Dictionary
  2. ^ do Valle, LA; de Melo, PR; de Gomes, LF; Proença, LM (13 Nov 1965). "Methisazone in prevention of variola minor among contacts". Lancet 2 (7420): 976–8. PMID 4159212. 
  3. ^ Weiss MM, Weiss PD, Mathisen G, Guze P (December 2004). "Rethinking smallpox". Clin. Infect. Dis. 39 (11): 1668–73. doi:10.1086/425745. PMID 15578369.