Nicotinyl alcohol
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| Clinical data | |
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| AHFS/Drugs.com | Monograph |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.002.604 |
| Chemical and physical data | |
| Formula | C6H7NO |
| Molar mass | 109.126 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.[1]
It appears as a crystal that dissolves in water and alcohol with ease, also soluble in eter; melting range 147-148º.[citation needed]
Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper torax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans, Raynaud's disease, thromboangiitis obliterans (Buerger's disease), arterial embolism, chilblains or migraine associated with vascular spasm.[citation needed]
Fischer y Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in syntoms related to intermittent claudication, ulcer healing and others.[2]
References
- ^ "Ronicol Retard". Medical Dictionary Online. 2012. Retrieved July 27, 2012.
- ^ Fisher MM, Tebrock HW (1953). "Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations". New York State Journal of Medicine. 53 (1): 65–8. PMID 13025721.
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