Phenylpyruvate tautomerase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
phenylpyruvate tautomerase
Identifiers
EC number 5.3.2.1
CAS number 9023-54-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, phenylpyruvate tautomerase or Macrophage migration inhibitory factor (EC 5.3.2.1) is an enzyme that catalyzes the chemical reaction

keto-phenylpyruvate \rightleftharpoons enol-phenylpyruvate

Phenylpyruvate tautomerase has also been found to exhibit the same keto-enol tautomerism for 4-Hydroxyphenylpyruvic acid, which is structurally similar to phenylpyruvate but contains an additional hydroxyl moiety in the para position of the aromatic ring.[1]

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

Structural studies[edit]

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GYJ, 1GYX, 1GYY, 2GDG, 2OOH, 2OOW, and 2OOZ.

References[edit]

  • Blasi F, Fragomele F, Covelli I (1969). "Thyroidal phenylpyruvate tautomerase. Isolation and characterization". J. Biol. Chem. 244 (18): 4864–70. PMID 5824560. 
  • Knox WE (1955). "p-Hydroxyphenylpyruvate enol-keto tautomerase". Methods Enzymol. 2: 289–295. 
  • KNOX WE, PITT BM (1957). "Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids". J. Biol. Chem. 225 (2): 675–88. PMID 13416270.