Yoshitaka made her acting debut in 2006. She was given the lead role in the live-action adaptation of Hitomi Kanehara's award-winning novel Snakes and Earrings in 2007. Portraying Lui, a teenager whose life goes into a downward spiral after meeting the forked-tongued and tattooed Ama, the role was Yoshitaka's breakthrough role. The Japanese public began to take notice of her, and in a poll conducted by Oricon, Yoshitaka was the fifth promising young actress of 2009 and 2009's freshest female celebrity. In 2010, Oricon again conducted a poll on the most promising actress and she managed climb up to top the poll.
Yoshitaka began to receive more work in 2008 as she appeared in Flow'smusic video "Arigatō" (ありがとう?, "Thanks"), was given her first lead role in the comedy drama Konno-san to Asobo(紺野さんと遊ぼう,Let’s Play with Konno-san?) and took up the lead role in the film Yubae Shōjo(夕映え少女,A Girl in the Sunset?) before the theatrical release of her other lead film Snakes and Earrings.
In 2009, Yoshitaka was given the role of the suicidal Kairi Hayakawa in the romantic-comedy dramaLove Shuffle. Later in the year, she portrayed Yūki Matsunaga (松永 由岐,Matsunaga Yūki?) in the police drama Tokyo Dogs with Shun Oguri and Hiro Mizushima as her co-stars.
In 2010, she starred as all three sisters in a short drama series titled Tofu Shimai(豆腐姉妹,lit. Tofu Sisters?). It was announced on May 13, 2010 that Yoshitaka was given her first lead role in a network television drama series called Mioka(美丘?), portraying a university student with an incurable illness.
She played Tae Kojima in the two-part 2011 live-action adaptation of the sci-fi and action manga Gantz. She also took the lead role in Kōji Maeda's movie Konzen Tokkyū, portraying a young woman dating multiple men in hopes of finding the right one to marry. It premiered in Spring 2011.
While she was preparing for her role in Snakes and Earrings, Yoshitaka was involved with a traffic accident in September 2007, and she suffered a fractured jaw. She stayed in the Intensive-care unit (ICU) for five days as a result.