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== Research ==
== Research ==
Sainis' studies in immunobiology have covered how [[T Cells]] and their receptors influence immune response to [[DNA]] in [[mycobacterial]] [[antigen]]s and [[lupus nephritis]], an [[autoimmune disease]].<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research |page=71 |date=1999}}</ref> He headed a group of scientists at BARC who were involved in research on [[Immunotherapy|immunomodulators]] based on plants.<ref name="PHISPCChakravorty">{{cite book|author1=PHISPC|author2=Burma and Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=F0o7BAAAQBAJ&pg=PA468|publisher=Pearson Education India|isbn=978-81-317-5373-6|pages=468–}}</ref> His studies have been documented and cited in texts and articles.{{Refn|group=note|Please see ''Selected bibliography'' section}}<ref name="Sainis KB [Author] ">{{Cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/?term=Sainis%20KB%5BAuthor%5D&cauthor=true&cauthor_uid=19447493 |title=Sainis KB [Author] |date=2017 |publisher=US National Library of Medicine}}</ref><ref name="Atta-ur-Rahman2017">{{cite book|author=Atta-ur-Rahman|title=Studies in Natural Products Chemistry|url=https://books.google.com/books?id=yZIxDQAAQBAJ&pg=PA486|date=17 February 2017|publisher=Elsevier Science|isbn=978-0-444-63937-0|pages=486–}}</ref><ref name="Radiation2009">{{cite book|author=United Nations. Scientific Committee on the Effects of Atomic Radiation|title=Effects of Ionizing Radiation: UNSCEAR 2006 Report to the General Assembly, with Scientific Annexes|url=https://books.google.com/books?id=xt-ZOQVfmj0C&pg=PA193|year=2009|publisher=United Nations Publications|isbn=978-92-1-142270-2|pages=193–}}</ref><ref name="BechtoldMussak2009">{{cite book|author1=Thomas Bechtold|author2=Rita Mussak|title=Handbook of Natural Colorants|url=https://books.google.com/books?id=hBFxuH5uXyIC&pg=PA253|date=6 April 2009|publisher=John Wiley & Sons|isbn=978-0-470-74496-3|pages=253–}}</ref><ref name="Yusuf">{{cite book|author=Dr. Mohd Yusuf|title=GREEN DYES AND PIGMENTS: CLASSES AND APPLICATIONS|url=https://books.google.com/books?id=nlpmDAAAQBAJ&pg=PA163|publisher=Lulu.com|isbn=978-1-329-93291-3|pages=163–}}</ref> He has also written chapters in books published by others.<ref name="Upadhyay1999">{{cite book|author=Shakti N. Upadhyay|title=Immunopharmacology: Strategies for Immunotherapy|url=https://books.google.com/books?id=hs8qglYfwHAC&pg=PR10|year=1999|publisher=CRC Press|isbn=978-0-8493-0951-9|pages=10–}}</ref><ref name="RaniYadav2014">{{cite book|author1=Vibha Rani|author2=Umesh Chand Singh Yadav|title=Free Radicals in Human Health and Disease|url=https://books.google.com/books?id=aTppBQAAQBAJ&pg=PA349|date=14 November 2014|publisher=Springer|isbn=978-81-322-2035-0|pages=349–}}</ref><ref name="Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles">{{Cite book |url=https://www.amrita.edu/publication/immunomodulatory-properties-stem-extracts-tinospora-cordifolia-cell-targets-and-active |title=Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles |last=K. B. Sainis, Sumariwalla, P. F., Goel, A., Chintalwar, G. J., Sipahimalani, A. T., and Banerji, A. |publisher=Narosa Publishing House |year=1997 |editor-last=S.N. Upadhyay |page=155}}</ref>
Sainis' studies in immunobiology have covered how [[T Cells]] and their receptors influence immune response to [[DNA]] in [[mycobacterial]] [[antigen]]s and [[lupus nephritis]], an [[autoimmune disease]].<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research |page=71 |date=1999}}</ref> He headed a group of scientists at BARC who were involved in research on [[Immunotherapy|immunomodulators]] based on plants.<ref name="PHISPCChakravorty">{{cite book|author1=PHISPC|author2=Burma and Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=F0o7BAAAQBAJ&pg=PA468|publisher=Pearson Education India|isbn=978-81-317-5373-6|pages=468–|year=1900}}</ref> His studies have been documented and cited in texts and articles.{{Refn|group=note|Please see ''Selected bibliography'' section}}<ref name="Sainis KB [Author] ">{{Cite journal |title=Sainis KB [Author] |journal=Biochemical Pharmacology |volume=24 |issue=20 |pages=1903–4 |date=2017 |pmid = 20|last1 = Barthel|first1 = W.|last2=Markwardt |first2=F. }}</ref><ref name="Atta-ur-Rahman2017">{{cite book|author=Atta-ur-Rahman|title=Studies in Natural Products Chemistry|url=https://books.google.com/books?id=yZIxDQAAQBAJ&pg=PA486|date=17 February 2017|publisher=Elsevier Science|isbn=978-0-444-63937-0|pages=486–}}</ref><ref name="Radiation2009">{{cite book|author=United Nations. Scientific Committee on the Effects of Atomic Radiation|title=Effects of Ionizing Radiation: UNSCEAR 2006 Report to the General Assembly, with Scientific Annexes|url=https://books.google.com/books?id=xt-ZOQVfmj0C&pg=PA193|year=2009|publisher=United Nations Publications|isbn=978-92-1-142270-2|pages=193–}}</ref><ref name="BechtoldMussak2009">{{cite book|author1=Thomas Bechtold|author2=Rita Mussak|title=Handbook of Natural Colorants|url=https://books.google.com/books?id=hBFxuH5uXyIC&pg=PA253|date=6 April 2009|publisher=John Wiley & Sons|isbn=978-0-470-74496-3|pages=253–}}</ref><ref name="Yusuf">{{cite book|author=Dr. Mohd Yusuf|title=GREEN DYES AND PIGMENTS: CLASSES AND APPLICATIONS|url=https://books.google.com/books?id=nlpmDAAAQBAJ&pg=PA163|publisher=Lulu.com|isbn=978-1-329-93291-3|pages=163–}}</ref> He has also written chapters in books published by others.<ref name="Upadhyay1999">{{cite book|author=Shakti N. Upadhyay|title=Immunopharmacology: Strategies for Immunotherapy|url=https://books.google.com/books?id=hs8qglYfwHAC&pg=PR10|year=1999|publisher=CRC Press|isbn=978-0-8493-0951-9|pages=10–}}</ref><ref name="RaniYadav2014">{{cite book|author1=Vibha Rani|author2=Umesh Chand Singh Yadav|title=Free Radicals in Human Health and Disease|url=https://books.google.com/books?id=aTppBQAAQBAJ&pg=PA349|date=14 November 2014|publisher=Springer|isbn=978-81-322-2035-0|pages=349–}}</ref><ref name="Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles">{{Cite book |url=https://www.amrita.edu/publication/immunomodulatory-properties-stem-extracts-tinospora-cordifolia-cell-targets-and-active |title=Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles |last=K. B. Sainis, Sumariwalla, P. F., Goel, A., Chintalwar, G. J., Sipahimalani, A. T., and Banerji, A. |publisher=Narosa Publishing House |year=1997 |editor-last=S.N. Upadhyay |page=155}}</ref>


==Affiliations and memberships==
==Affiliations and memberships==
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=== Articles ===
=== Articles ===
* {{Cite journal |last=Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar GJ, Sainis KB |title=Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia |journal=Immunol. Lett. |publication-date=2009 |volume=23 |issue=1 |pages=60–71 |doi=10.1016/j.imlet.2009.02.005}}
* {{Cite journal |last=Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar GJ, Sainis KB |title=Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia |journal=Immunol. Lett. |date=2009 |volume=23 |issue=1 |pages=60–71 |doi=10.1016/j.imlet.2009.02.005|pmid=19428553 }}
* {{Cite journal |last=Deepak Sharma, S. Santosh Kumar, Rahul Checker, Rashmi Raghu, Shazia Khanam, Sunil Krishnan, Krishna Balaji Sainis |title=Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4+ T cells |journal=Mol. Immunol. |publication-date=2009 |volume=46 |issue=11-12 |pages=2403–2412 |doi=10.1016/j.molimm.2009.04.019|pmc=3090723 }}
* {{Cite journal |last=Deepak Sharma, S. Santosh Kumar, Rahul Checker, Rashmi Raghu, Shazia Khanam, Sunil Krishnan, Krishna Balaji Sainis |title=Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4+ T cells |journal=Mol. Immunol. |date=2009 |volume=46 |issue=11–12 |pages=2403–2412 |doi=10.1016/j.molimm.2009.04.019|pmid=19447493 |pmc=3090723 }}
* {{Cite journal |last=Checker R, Sandur SK, Sharma D, Patwardhan RS, Jayakumar S, Kohli V, Sethi G, Aggarwal BB, Sainis KB |title=Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT |journal=PLoS One |publication-date=2012 |volume=7 |issue=2 |pages=e31318 |doi=10.1371/journal.pone.0031318}}
* {{Cite journal |last=Checker R, Sandur SK, Sharma D, Patwardhan RS, Jayakumar S, Kohli V, Sethi G, Aggarwal BB, Sainis KB |title=Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT |journal=PLoS One |date=2012 |volume=7 |issue=2 |pages=e31318 |doi=10.1371/journal.pone.0031318|pmid=22363615 |pmc=3282718 |bibcode=2012PLoSO...731318C }}
* {{Cite journal |last=Patwardhan RS, Checker R, Sharma D, Sandur SK, Sainis KB |title=Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells |journal=PLoS One |publication-date=2013 |volume=8 |issue=6 |pages=e65929 |doi=10.1371/journal.pone.0065929}}
* {{Cite journal |last=Patwardhan RS, Checker R, Sharma D, Sandur SK, Sainis KB |title=Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells |journal=PLoS One |date=2013 |volume=8 |issue=6 |pages=e65929 |doi=10.1371/journal.pone.0065929|pmid=23776571 |pmc=3679038 |bibcode=2013PLoSO...865929P }}
* {{Cite journal |last=Suryavanshi S, Sharma D, Checker R, Thoh M, Gota V, Sandur SK, Sainis KB |title=Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis |journal=Free Radic Biol Med |publication-date=2015 |volume=85 |pages=56–70 |doi=10.1016/j.freeradbiomed.2015.04.007}}
* {{Cite journal |last=Suryavanshi S, Sharma D, Checker R, Thoh M, Gota V, Sandur SK, Sainis KB |title=Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis |journal=Free Radic Biol Med |date=2015 |volume=85 |pages=56–70 |doi=10.1016/j.freeradbiomed.2015.04.007|pmid=25872101 }}


== See also ==
== See also ==

Revision as of 01:16, 30 December 2018

K. B. Sainis
Born (1949-10-20) 20 October 1949 (age 75)
Maharashtra, India
NationalityIndian
Alma mater
Known forImmunobiology research
Awards
Scientific career
Fields
Institutions

Krishna Balaji Sainis (born 20 October 1949) is an Indian immunologist. He is a senior professor of Life Sciences at Homi Bhabha National Institute and an elected fellow of the National Academy of Sciences, India. Since 1999, he has served as the Indian representative on the United Nations Scientific Committee on the Effects of Atomic Radiation. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology for his contributions to medical sciences in 1994.

Biography

University of Pune

Born on 20 October 1949, K. B. Sainis earned a master's degree in biochemistry (MSc) from Savitribai Phule Pune University and did a one-year course in biology and radiobiology at Bhabha Atomic Research Centre (BARC).[1] Upon completion of the course in 1972, he joined BARC as a Scientific Officer while continuing his doctoral studies at Pune University and secured a PhD in biophysics in 1980. Taking a sabbatical, he did his post-doctoral studies at the New England Medical Centre of Tufts University School of Medicine and, with the assistance of an IAEA fellowship, he completed his studies at University College London at its ICRF Tumor Immunology Unit.[2]

Returning to BARC, he served in many positions, heading the Immunology Section and the Cell Biology Division and serving as the associate director of the Bioscience Group. He became director of the Bio-Medical Group in 2006, with the responsibility of six divisions.[3] During his service at BARC, he has also been working as a faculty at the department of Life Sciences of the Homi Bhabha National Institute where he is a senior professor.[2]

Sainis is married to Jayashree Krishna Sainis, a biochemist, and the family lives in Navi Mumbai.[4]

Research

Sainis' studies in immunobiology have covered how T Cells and their receptors influence immune response to DNA in mycobacterial antigens and lupus nephritis, an autoimmune disease.[5] He headed a group of scientists at BARC who were involved in research on immunomodulators based on plants.[6] His studies have been documented and cited in texts and articles.[note 1][7][8][9][10][11] He has also written chapters in books published by others.[12][13][14]

Affiliations and memberships

Sainis has been associated with two international agencies. He served as president of the Standing Advisory Group on Nuclear Applications (SAGNA) of the International Atomic Energy Agency (IAEA) in 2012, and since 1999 has served as the Indian representative on the United Nations Scientific Committee on the Effects of Atomic Radiation.[1][15][16]

Sainis is the president of the Mumbai Immunology Group at Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) of the Tata Memorial Centre[17] and a former vice president of the Maharashtra Academy of Sciences.[18] He is an honorary adviser to the Society for Free Radical Research India (SFRR-India);[19][20] a member of the Advisory Committee of the National Training Program on Radiation Processing of Food for Food and Quarantine Inspectors & Quality Control Personnel organized by Department of Atomic Energy in association with BARC in February 2013;[21] and a member of the Indian Immunology Society.[22]

He was previously associated with ongoing education programs such as the XVII Training Workshop on Radiation Emergency Preparedness for Medical Officers,[23] the Refresher Course 2013 of the Indian Women Scientists Association,[24] and the AKRUTI Technology Package for Rural Deployment of BARC.[25] He has delivered several invited speeches or keynote addresses[26][27] and is a reviewer for Hindawi journals.[28]

Awards and honors

The Council of Scientific and Industrial Research awarded Sainis the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 1994.[29][30] The National Academy of Sciences, India elected him as a fellow in 2002.[31] He is also an elected fellow of the Maharashtra Academy of Sciences.[32]

Selected bibliography

Chapters

  • K. B. Sainis, Sumariwalla, P. F., Goel, A., Chintalwar, G. J., Sipahimalani, A. T., and Banerji, A. (1997). S.N. Upadhyay (ed.). Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles. Narosa Publishing House. p. 155.{{cite book}}: CS1 maint: multiple names: authors list (link)
  • Shakti N. Upadhyay (1999). Immunopharmacology: Strategies for Immunotherapy. CRC Press. pp. 10–. ISBN 978-0-8493-0951-9.
  • Vibha Rani; Umesh Chand Singh Yadav (14 November 2014). Free Radicals in Human Health and Disease. Springer. pp. 349–. ISBN 978-81-322-2035-0.

Articles

See also

Notes

  1. ^ Please see Selected bibliography section

References

  1. ^ a b "Professor Dr. Krishna B. Sainis on UNSCEAR". UN Scientific Committee on the Effects of Atomic Radiation. 2017.
  2. ^ a b "Senior professor - Life Sciences". Homi Bhabha National Institute. 2017.
  3. ^ "Dr. Krishna Balaji Sainis on Vidwan". Vidwan Iflibnet. 2017.
  4. ^ "NASI fellows". National Academy of Sciences, India. 2017. Archived from the original on 16 March 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  5. ^ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 71.
  6. ^ PHISPC; Burma and Chakravorty (1900). From Physiology and Chemistry to Biochemistry. Pearson Education India. pp. 468–. ISBN 978-81-317-5373-6.
  7. ^ Barthel, W.; Markwardt, F. (2017). "Sainis KB [Author]". Biochemical Pharmacology. 24 (20): 1903–4. PMID 20.
  8. ^ Atta-ur-Rahman (17 February 2017). Studies in Natural Products Chemistry. Elsevier Science. pp. 486–. ISBN 978-0-444-63937-0.
  9. ^ United Nations. Scientific Committee on the Effects of Atomic Radiation (2009). Effects of Ionizing Radiation: UNSCEAR 2006 Report to the General Assembly, with Scientific Annexes. United Nations Publications. pp. 193–. ISBN 978-92-1-142270-2.
  10. ^ Thomas Bechtold; Rita Mussak (6 April 2009). Handbook of Natural Colorants. John Wiley & Sons. pp. 253–. ISBN 978-0-470-74496-3.
  11. ^ Dr. Mohd Yusuf. GREEN DYES AND PIGMENTS: CLASSES AND APPLICATIONS. Lulu.com. pp. 163–. ISBN 978-1-329-93291-3.
  12. ^ Shakti N. Upadhyay (1999). Immunopharmacology: Strategies for Immunotherapy. CRC Press. pp. 10–. ISBN 978-0-8493-0951-9.
  13. ^ Vibha Rani; Umesh Chand Singh Yadav (14 November 2014). Free Radicals in Human Health and Disease. Springer. pp. 349–. ISBN 978-81-322-2035-0.
  14. ^ K. B. Sainis, Sumariwalla, P. F., Goel, A., Chintalwar, G. J., Sipahimalani, A. T., and Banerji, A. (1997). S.N. Upadhyay (ed.). Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles. Narosa Publishing House. p. 155.{{cite book}}: CS1 maint: multiple names: authors list (link)
  15. ^ United Nations. Scientific Committee on the Effects of Atomic Radiation (2008). Report of the United Nations Scientific Committee on the Effects of Atomic Radiation: Fifty-sixth Session (10-18 July 2008). United Nations Publications. pp. 30–. GGKEY:B5URFLG7851.
  16. ^ United Nations. Scientific Committee on the Effects of Atomic Radiation (2000). Sources and Effects of Ionizing Radiation: Sources. United Nations Publications. pp. 16–. ISBN 978-92-1-142238-2.
  17. ^ "President - Mumbai Immunology Group". Mumbai Immunology Group - ACTREC. 2017.
  18. ^ "Special ASET Colloquium" (PDF). Tata Institute of Fundamental Research. 2017.
  19. ^ "Current Managing Committee (2016-2018)". SFFR India. 2017.
  20. ^ "Honorary Advisers". AIIMS. 2017.
  21. ^ "Advisory Committee National Training Program on Radiation Processing" (PDF). Global Centre for Nuclear Energy Partnership. 2017.
  22. ^ "IIS Member" (PDF). Indian Immunology Society. 2017.
  23. ^ "XVII Training Workshop on Radiation Emergency Preparedness for Meeical Officers" (PDF). BARC. 2017.
  24. ^ "Refresher Course 2013". Indian Women Scientists Association. 2017.
  25. ^ "AKRUTI Technology Package for Rural Deployment". BARC. 2017.
  26. ^ "The Director, Bio-Medical Group, BARC, Mumbai, Dr. K.B. Sainis addressing". Sarkari Mirror. 25 September 2013.
  27. ^ "RADIATION AND SOCIETY: Benefits and Apprehensions". Tata Institute of Fundamental Research. 2017.
  28. ^ "India: Reviewers Hindawi journals". Hindawi. 2017.
  29. ^ "Medical Sciences". Council of Scientific and Industrial Research. 2017. Archived from the original on 24 February 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  30. ^ "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 12 November 2016.
  31. ^ "Zone wise list of Fellows & Honorary Fellows" (PDF). National Academy of Sciences, India. 2017.
  32. ^ "MAS fellows". Maharashtra Academy of Sciences. 2017.

Further reading

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