Decongestant: Difference between revisions
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Most decongestants cause response from [[adrenoreceptor]] a<sub>1</sub>, chiefly responsible for [[vasoconstriction]] (a<sub>2</sub> modulates [[adrenaline]]/[[noradrenaline]] levels, b<sub>1</sub> is the most [[stimulant| stimulating]] and increases [[cardiac output]], b<sub>2</sub> [[bronchodilation| dilates the bronchial walls]], and b<sub>3</sub> induces [[lipolysis]]). The effects are not limited to the nose and these medicines can increase hypertension (blood pressure) through [[vasoconstriction]], but most decongestants are not pronounced stimulants due to lack of response from the other adrenoreceptors. |
Most decongestants cause response from [[adrenoreceptor]] a<sub>1</sub>, chiefly responsible for [[vasoconstriction]] (a<sub>2</sub> modulates [[adrenaline]]/[[noradrenaline]] levels, b<sub>1</sub> is the most [[stimulant| stimulating]] and increases [[cardiac output]], b<sub>2</sub> [[bronchodilation| dilates the bronchial walls]], and b<sub>3</sub> induces [[lipolysis]]). The effects are not limited to the nose and these medicines can increase hypertension (blood pressure) through [[vasoconstriction]], but most decongestants are not pronounced stimulants due to lack of response from the other adrenoreceptors. |
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These are normally paired with [[antihistamines]] to lessen this effect, but they don't always even each other out. |
These are normally paired with [[antihistamines]] to lessen this effect, but they don't always even each other out. {{fact}} |
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==Administration== |
==Administration== |
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Revision as of 02:23, 19 February 2008
A decongestant is a broad class of medications used to relieve nasal congestion. Generally, they work by reducing swelling of the mucous membranes in the nasal passages.
Mechanism
Most decongestants cause response from adrenoreceptor a1, chiefly responsible for vasoconstriction (a2 modulates adrenaline/noradrenaline levels, b1 is the most stimulating and increases cardiac output, b2 dilates the bronchial walls, and b3 induces lipolysis). The effects are not limited to the nose and these medicines can increase hypertension (blood pressure) through vasoconstriction, but most decongestants are not pronounced stimulants due to lack of response from the other adrenoreceptors.
These are normally paired with antihistamines to lessen this effect, but they don't always even each other out. [citation needed]
Administration
These agents are usually administered topically (by the intranasal route) or orally.
Examples
The most common oral decongestants are pseudoephedrine and phenylephrine; phenylpropanolamine (PPA) is another, although it's no longer available in the US. Oxymetazoline and phenylephrine are a commonly available topical decongestants (nasal sprays).
See also
- Nasal congestion (includes non-pharmacological remedies)
- Topical decongestant
- Adrenoreceptor
- Expectorant
Major chemical drug groups – based upon the Anatomical Therapeutic Chemical Classification System | |
|---|---|
| gastrointestinal tract / metabolism (A) | |
| blood and blood forming organs (B) | |
| cardiovascular system (C) | |
| skin (D) | |
| genitourinary system (G) | |
| endocrine system (H) | |
| infections and infestations (J, P, QI) | |
| malignant disease (L01–L02) | |
| immune disease (L03–L04) | |
| muscles, bones, and joints (M) | |
| brain and nervous system (N) |
|
| respiratory system (R) | |
| sensory organs (S) | |
| other ATC (V) | |
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