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==Anatomy==
==Anatomy==


[[Image:Kidney section.jpg|thumb|left|Above each human kidney is one of the two [[adrenal gland]]s.]]
[[Image:Gray1127.png|thumb|left|Above each human kidney is one of the two [[adrenal gland]]s.]]
In a normal [[human]] adult, each kidney is about 10 cm long, 5.5 cm in width and about 3 cm thick, weighing 150 grams.<ref>{{cite book|author=Martini F. |title=Fundamentals of Anatomy and Physiology 5th edition. Prentice Hall International Inc. 2001}}</ref> Together, kidneys weigh about 0.5% of a person's total body weight {{Fact|date=August 2007}}. The kidneys are "bean-shaped" organs, and have a [[wiktionary:Concave|concave]] side facing inwards (medially). On this medial aspect of each kidney is an opening, called the [[hilum]], which admits the renal [[artery]], the renal [[vein]], [[nerve]]s, and the [[ureter]].
In a normal [[human]] adult, each kidney is about 10 cm long, 5.5 cm in width and about 3 cm thick, weighing 150 grams.<ref>{{cite book|author=Martini F. |title=Fundamentals of Anatomy and Physiology 5th edition. Prentice Hall International Inc. 2001}}</ref> Together, kidneys weigh about 0.5% of a person's total body weight {{Fact|date=August 2007}}. The kidneys are "bean-shaped" organs, and have a [[wiktionary:Concave|concave]] side facing inwards (medially). On this medial aspect of each kidney is an opening, called the [[hilum]], which admits the renal [[artery]], the renal [[vein]], [[nerve]]s, and the [[ureter]].


Revision as of 22:02, 23 April 2008

Kidney
File:Kidneys from behind.jpg
Human kidneys viewed from behind with spine removed
Details
Arteryrenal artery
Veinrenal vein
Nerverenal plexus
Identifiers
Latinren
MeSHD007668
TA98A08.1.01.001
TA23358
FMA7203
Anatomical terminology

The kidneys are complex organs that have numerous biological roles. Their primary role is to maintain the homeostatic balance of bodily fluids by filtering and secreting metabolites (such as urea) and minerals from the blood and excreting them, along with water, as urine. Because the kidneys are poised to sense plasma concentrations of ions such as sodium, potassium, hydrogen, oxygen, and compounds such as amino acids, creatine, bicarbonate, and glucose, they are important regulators of blood pressure, glucose metabolism, and erythropoeisis (the process by which red blood cells (erythrocytes) are produced). The medical field that studies the kidneys and diseases of the kidney is called nephrology[1]. The prefix nephro- meaning kidney is from the Ancient Greek word nephros (νεφρός); the adjective renal meaning related to the kidney is from Latin rēnēs, meaning kidneys. [2]

In humans, the kidneys are located in the posterior part of the abdomen. There is one on each side of the spine; the right kidney sits just below the liver, the left below the diaphragm and adjacent to the spleen. Above each kidney is an adrenal gland (also called the suprarenal gland). The asymmetry within the abdominal cavity caused by the liver results in the right kidney being slightly lower than the left one while the left kidney is located slightly more medial.

The kidneys are retroperitoneal and range from 9 to 13 cm in diameter; the left slightly larger than the right. They are approximately at the vertebral level T12 to L3. The upper parts of the kidneys are partially protected by the eleventh and twelfth ribs, and each whole kidney is surrounded by two layers of fat (the perirenal and pararenal fat) which help to cushion it. Congenital absence of one or both kidneys, known as unilateral or bilateral renal agenesis, can occur.

Anatomy

Above each human kidney is one of the two adrenal glands.

In a normal human adult, each kidney is about 10 cm long, 5.5 cm in width and about 3 cm thick, weighing 150 grams.[3] Together, kidneys weigh about 0.5% of a person's total body weight [citation needed]. The kidneys are "bean-shaped" organs, and have a concave side facing inwards (medially). On this medial aspect of each kidney is an opening, called the hilum, which admits the renal artery, the renal vein, nerves, and the ureter.

The outer portion of the kidney is called the renal cortex, which sits directly beneath the kidney's loose connective tissue/fibrous capsule. Deep to the cortex lies the renal medulla, which is divided into 10-20 renal pyramids in humans. Each pyramid together with the associated overlying cortex forms a renal lobe. The tip of each pyramid (called a papilla) empties into a minor calyx, which empties into one of the 3-5 major calices, which in turn empty into the renal pelvis. The pelvis transmits urine to the urinary bladder via the ureter. People are born with two kidneys but are able to live with only one.

The poles are the highest and lowest points of the kidney. Since the kidneys are located on different heights, the upper pole of the right kidney is at the same level as the hilum of the left kidney. This also happens to be at the same level as the transpyloric plane.[4]

Blood supply

Main article: Renal circulation

The two kidneys together receive between 20% and 25% of the total cardiac output.

Innervation

The kidney is innervated by the renal and ureteric nerve, which arises from the renal plexus. [5] It is sympathetic, parasympathetic and visceral afferent.[5] The renal plexus, in turn, is innervated by thoracic splanchnic nerves, especially the caudal ones.[5]

Nephron

Parts of the kidney:
1. Renal pyramid         
2. Efferent artery
3. Renal artery
4. Renal vein
5. Renal hilum
6. Renal pelvis
7. Ureter
8. Minor calyx
9. Renal capsule		10. Inferior renal capsule
11. Superior renal
      capsule
12. Afferent vein
13. Nephron
14. Minor calyx
15. Major calyx
16. Renal papilla
17. Renal column
Main article: Nephron

The basic functional unit of the kidney is the nephron, of which there are more than a million within the cortex and medulla of each normal adult human kidney.

Collecting duct system

Main article: Collecting duct system

The fluid flows from the nephron into the collecting duct system.

Functions

Main article: Renal physiology

Excretion of waste products

The kidneys excrete a variety of waste products produced by metabolism, including the nitrogenous wastes: urea (from protein catabolism) and uric acid (from nucleic acid metabolism) and water.

Homeostasis

The kidney is one of the major organs involved in whole-body homeostasis. Among its homeostatic functions are acid-base balance, regulation of electrolyte concentrations, control of blood volume, and regulation of blood pressure. The kidneys accomplish these homeostatic functions independently and through coordination with other organs, particularly those of the endocrine system. The kidney communicates with these organs through hormones secreted into the bloodstream.

Acid-base balance

The kidneys regulate the pH of blood by adjusting H+ ion levels, referred as augmentation of mineral ion concentration, as well as water composition of the blood.

Blood pressure

Main article: Renin-angiotensin system

Sodium ions are controlled in a homeostatic process involving aldosterone which increases sodium ion reabsorption in the distal convoluted tubules.

Plasma volume

Any significant rise or drop in plasma osmolality is detected by the hypothalamus, which communicates directly with the posterior pituitary gland. A rise in osmolality causes the gland to secrete antidiuretic hormone, resulting in water reabsorption by the kidney and an increase in urine concentration and volume. The two factors work together to return the plasma osmolality to its normal levels.

Hormone secretion

The kidneys secrete a variety of hormones, including erythropoietin, urodilatin, renin and vitamin D.

Embryology

Main article: Development of the urinary and reproductive organs

The mammalian kidney develops from intermediate mesoderm. Kidney development, also called nephrogenesis, proceeds through a series of three successive phases, each marked by the development of a more advanced pair of kidneys: the pronephros, mesonephros, and metanephros.[6] (The plural forms of these terms end in -oi.)

Pronephros

Main article: Pronephros

During approximately day 22 of human gestation, the paired pronephroi appear towards the cranial end of the intermediate mesoderm. In this region, epithelial cells arrange themselves in a series of tubules called nephrotomes and join laterally with the pronephric duct, which does not reach the outside of the embryo. Thus the pronephros is considered nonfunctional in mammals because it cannot excrete waste from the embryo.

Mesonephros

Main article: Mesonephros

Each pronephric duct grows towards the tail of the embryo, and in doing so induces intermediate mesoderm in the thoracolumbar area to become epithelial tubules called mesonephric tubules. Each mesonephric tubule receives a blood supply from a branch of the aorta, ending in a capillary tuft analogous to the glomerulus of the definitive nephron. The mesonephric tubule forms a capsule around the capillary tuft, allowing for filtration of blood. This filtrate flows through the mesonephric tubule and is drained into the continuation of the pronephric duct, now called the mesonephric duct or Wolffian duct. The nephrotomes of the pronephros degenerate while the mesonephric duct extends towards the most caudal end of the embryo, ultimately attaching to the cloaca. The mammalian mesonephros is similar to the kidneys of aquatic amphibians and fishes.

Metanephros

During the fifth week of gestation, the mesonephric duct develops an outpouching, the ureteric bud, near its attachment to the cloaca. This bud, also called the metanephrogenic diverticulum, grows posteriorly and towards the head of the embryo. The elongated stalk of the ureteric bud, the metanephric duct, later forms the ureter. As the cranial end of the bud extends into the intermediate mesoderm, it undergoes a series of branchings to form the collecting duct system of the kidney. It also forms the major and minor calyces and the renal pelvis.

The portion of undifferentiated intermediate mesoderm in contact with the tips of the branching ureteric bud is known as the metanephrogenic blastema. Signals released from the ureteric bud induce the differentiation of the metanephrogenic blastema into the renal tubules. As the renal tubules grow, they come into contact and join with connecting tubules of the collecting duct system, forming a continuous passage for flow from the renal tubule to the collecting duct. Simultaneously, precursors of vascular endothelial cells begin to take their position at the tips of the renal tubules. These cells differentiate into the cells of the definitive glomerulus.

Terms

Microscopic photograph of the renal cortex.
Microscopic photograph of the renal medulla.
  • renal capsule: The membranous covering of the kidney.
  • cortex: The outer layer over the internal medulla. It contains blood vessels, glomeruli (which are the kidneys' "filters") and urine tubes and is supported by a fibrous matrix.
  • hilus: The opening in the middle of the concave medial border for nerves and blood vessels to pass into the renal sinus.
  • renal column: The structures which support the cortex. They consist of lines of blood vessels and urinary tubes and a fibrous material.
  • renal sinus: The cavity which houses the renal pyramids.
  • calyces: The recesses in the internal medulla which hold the pyramids. They are used to subdivide the sections of the kidney. (singular - calyx)
  • papillae: The small conical projections along the wall of the renal sinus. They have openings through which urine passes into the calyces. (singular - papilla)
  • renal pyramids: The conical segments within the internal medulla. They contain the secreting apparatus and tubules and are also called malpighian pyramids.
  • renal artery: Two renal arteries come from the aorta, each connecting to a kidney. The artery divides into five branches, each of which leads to a ball of capillaries. The arteries supply (unfiltered) blood to the kidneys. The left kidney receives about 60% of the renal bloodflow.
  • renal vein: The filtered blood returns to circulation through the renal veins which join into the inferior vena cava.
  • renal pelvis: Basically just a funnel, the renal pelvis accepts the urine and channels it out of the hilus into the ureter.
  • ureter: A narrow tube 40 cm long and 4 mm in diameter. Passing from the renal pelvis out of the hilus and down to the bladder. The ureter carries urine from the kidneys to the bladder by means of peristalsis.
  • renal lobe: Each pyramid together with the associated overlying cortex forms a renal lobe

Diseases and disorders

Congenital

Acquired

drawing of an enlarged kidney by John Hunter

The failing kidney

Generally, humans can live normally with just one kidney, as one has more functioning renal tissue than is needed to survive, possibly due to the nature of the prehistoric human diet. Only when the amount of functioning kidney tissue is greatly diminished will Stage 5 Chronic Kidney Disease develop. If the glomerular filtration rate (a measure of renal function) has fallen very low ( Stage 5 Chronic Kidney Disease), or if the renal dysfunction leads to severe symptoms, then renal replacement therapy is indicated, either dialysis or kidney transplantation.

Medical terminology

  • Medical terms related to the kidneys involve the prefixes renal- and nephro-.
  • Surgical removal of the kidney is a nephrectomy, while a radical nephrectomy is removal of the kidney, its surrounding tissue, lymph nodes, and potentially the adrenal gland. A radical nephrectomy is performed for the removal of the cancers.

Histology

Human cell types found in the kidney include:

Animal kidneys as food

The kidneys of animals can be cooked and eaten by humans (along with other offal). If prepared properly, they can be nutritious and pleasant tasting. Veal kidneys and lamb kidneys are particularly prized for their tenderness and flavour. Kidneys can be grilled or sautéed, though they become tough and unpleasant if overcooked.

See also

References

Wikimedia Commons has media related to Kidneys.
  1. ^ "Nephrology". Dictionary.com. Retrieved 2007-08-04.
  2. ^ Maton, Anthea (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1. {{cite book}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ Martini F. Fundamentals of Anatomy and Physiology 5th edition. Prentice Hall International Inc. 2001.
  4. ^ Bålens ytanatomi (surface anatomy). Godfried Roomans, Mats Hjortberg and Anca Dragomir. Institution for Anatomy, Uppsala. 2008.]]
  5. ^ a b c Essential Clinical Anatomy. K.L. Moore & A.M. Agur. Lippincott, 2 ed. 2002.
  6. ^ Bruce M. Carlson (2004). Human Embryology and Developmental Biology (3rd edition ed.). Saint Louis: Mosby. ISBN 0-323-03649-X. {{cite book}}: |edition= has extra text (help)
  7. ^ mednote.co
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