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| section_title =
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| summary_text = This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
| summary_text = This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
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==Interactions==
==Interactions==
PPP2R1B has been shown to [[Protein-protein_interaction|interact]] with [[PPP2R5E]],<ref name=pmid8703017>{{cite journal |last=McCright |first=B |authorlink= |coauthors=Rivers A M, Audlin S, Virshup D M |year=[[1996]]|month=Sep. |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm |journal=J. Biol. Chem. |volume=271 |issue=36 |pages=22081–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8703017 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.36.22081 }}</ref> [[PPP2R5D]],<ref name=pmid8703017/> [[PPP2R3B]],<ref name=pmid12370081>{{cite journal |last=Zhou |first=Jin |authorlink= |coauthors=Pham Huong T, Ruediger Ralf, Walter Gernot |year=[[2003]]|month=Jan. |title=Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution |journal=Biochem. J. |volume=369 |issue=Pt 2 |pages=387–98 |publisher= |location = England| issn = 0264-6021| pmid = 12370081 |doi = 10.1042/BJ20021244 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1223084 }}</ref> [[PPP2R2A]],<ref name=pmid1328247>{{cite journal |last=Kamibayashi |first=C |authorlink= |coauthors=Lickteig R L, Estes R, Walter G, Mumby M C |year=[[1992]]|month=Oct. |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits |journal=J. Biol. Chem. |volume=267 |issue=30 |pages=21864–72 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 1328247 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12370081/> [[PPP2R5C]],<ref name=pmid8703017/> [[PPP2R5B]],<ref name=pmid8703017/> [[PPP2R5A]],<ref name=pmid18782753>{{cite journal |last=Goudreault |first=Marilyn |authorlink= |coauthors=D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |year=[[2009]]|month=Jan. |title=A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein |journal=Mol. Cell Proteomics |volume=8 |issue=1 |pages=157–71 |publisher= |location = United States| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2621004 }}</ref><ref name=pmid12370081/><ref name=pmid8703017/> [[PPP2CB]]<ref name=pmid12370081/> and [[PPP2CA]].<ref name=pmid18782753/><ref name=pmid12370081/>
PPP2R1B has been shown to [[Protein-protein interaction|interact]] with [[PPP2R5E]],<ref name=pmid8703017>{{cite journal |last=McCright |first=B |authorlink= |coauthors=Rivers A M, Audlin S, Virshup D M |year=[[1996]]|month=Sep. |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm |journal=J. Biol. Chem. |volume=271 |issue=36 |pages=22081–9 |publisher= |location = United States| issn = 0021-9258| pmid = 8703017 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.36.22081 }}</ref> [[PPP2R5D]],<ref name=pmid8703017/> [[PPP2R3B]],<ref name=pmid12370081>{{cite journal |last=Zhou |first=Jin |authorlink= |coauthors=Pham Huong T, Ruediger Ralf, Walter Gernot |year=[[2003]]|month=Jan. |title=Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution |journal=Biochem. J. |volume=369 |issue=Pt 2 |pages=387–98 |publisher= |location = England| issn = 0264-6021| pmid = 12370081 |doi = 10.1042/BJ20021244 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1223084 }}</ref> [[PPP2R2A]],<ref name=pmid12370081/><ref name=pmid1328247>{{cite journal |last=Kamibayashi |first=C |authorlink= |coauthors=Lickteig R L, Estes R, Walter G, Mumby M C |year=[[1992]]|month=Oct. |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits |journal=J. Biol. Chem. |volume=267 |issue=30 |pages=21864–72 |publisher= |location = United States| issn = 0021-9258| pmid = 1328247 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPP2R5C]],<ref name=pmid8703017/> [[PPP2R5B]],<ref name=pmid8703017/> [[PPP2R5A]],<ref name=pmid8703017/><ref name=pmid12370081/><ref name=pmid18782753>{{cite journal |last=Goudreault |first=Marilyn |authorlink= |coauthors=D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |year=[[2009]]|month=Jan. |title=A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein |journal=Mol. Cell Proteomics |volume=8 |issue=1 |pages=157–71 |publisher= |location = United States| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2621004 }}</ref> [[PPP2CB]]<ref name=pmid12370081/> and [[PPP2CA]].<ref name=pmid12370081/><ref name=pmid18782753/>


==References==
==References==
{{reflist}}
{{Reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
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| citations =
| citations =
*{{cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=10.1016/S0006-2952(00)00424-X }}
*{{cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=10.1016/S0006-2952(00)00424-X }}
*{{cite journal | author=Kamibayashi C |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21864–72 |year= 1992 |pmid= 1328247 |doi= | author-separator=, | author2=Lickteig RL | author3=Estes R | display-authors=3 | last4=Walter | first4=G | last5=Mumby | first5=MC }}
*{{cite journal | author=Kamibayashi C |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21864–72 |year= 1992 |pmid= 1328247 |doi= | author-separator=, | author2=Lickteig RL | author3=Estes R | display-authors=3 | last4=Walter | first4=G | last5=Mumby | first5=MC }}
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Revision as of 14:38, 14 November 2011

Template:PBB Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.[1][2][3]

Template:PBB Summary

Interactions

PPP2R1B has been shown to interact with PPP2R5E,[4] PPP2R5D,[4] PPP2R3B,[5] PPP2R2A,[5][6] PPP2R5C,[4] PPP2R5B,[4] PPP2R5A,[4][5][7] PPP2CB[5] and PPP2CA.[5][7]

References

  1. ^ Hemmings BA, Adams-Pearson C, Maurer F, Muller P, Goris J, Merlevede W, Hofsteenge J, Stone SR (1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–73. doi:10.1021/bi00465a002. PMID 2159327. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Baysal BE, Farr JE, Goss JR, Devlin B, Richard CW 3rd (1998). "Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23". Gene. 217 (1–2): 107–16. doi:10.1016/S0378-1119(98)00350-3. PMID 9795170. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  3. ^ "Entrez Gene: PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform".
  4. ^ a b c d e McCright, B (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36). United States: 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  5. ^ a b c d e Zhou, Jin (2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. 369 (Pt 2). England: 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  6. ^ Kamibayashi, C (1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. 267 (30). United States: 21864–72. ISSN 0021-9258. PMID 1328247. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  7. ^ a b Goudreault, Marilyn (2009). "A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein". Mol. Cell Proteomics. 8 (1). United States: 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)

Further reading

Template:PBB Further reading

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