Talk:Ivermectin

USE OF IVERMECTIN IN CAMELS

In Isiolo(Kenya)there has been an outbreak of an unknown disease that is killing camels without any symptoms. The animals dying are normally very healthy, either lactating or pregnant. Since the Minstry of livestock has not been able to diagonise the problem, Farmers are trying all sorts of medicines. Some farmers have tried the IVOMEC and are claiming to have stopped the deaths.41.223.57.34 11:21, 20 May 2007 (UTC)JAMES MACHARIA KARANI P .O. BOX 277 ISIOLO e-mail adress jamesmkarani@yahoo.com

Dangerous and illegal dosing information for pet owners

I am very concerned about the content in this article that advises dog owners of how to treat their pets with Ivermectin intended for cattle. The average citizen is not skilled in calculating drug dosages or administering drugs and could easily overdose their pet dog. Also, Ivermectin should not be administered for heartworm prevention unless the dogs are known to be currently free of heartworm disease. If a pet owner reads this information and administers Ivermectin to a dog that is infected with heartworms, it would cause a massive die-off of the microfilarial lifestage, which could cause kidney failure, respiratory distress, and an acute immune reaction by the dog. Basically, people could easily kill their pets by following the advice on this page. Also, it is illegal for a non-veterinarian to use veterinary drugs off-label, such as using a drug labelled for cattle in a dog. Please, for the safety of our pets, remove this off-label dosing information from this webpage. "A little knowledge is a dangerous thing." 03:46, 10 July 2007 (UTC) Someone who cares

Thanks for pointing that out. I made the changes. --Joelmills 04:01, 10 July 2007 (UTC)

Heartgard

This article ought to mention Heartgard to explain why it redirects here. ~ Booya ^Bazooka 18:05, 10 September 2011 (UTC)

Agreed. Ivermectin is the primary ingredient in Heartgard, used to treat heartworms in dogs (and perhaps other animals). I'm not sure I like the statement early in the article that Ivermectin is sold under certain brand names in various countries, as that list is certainly not completely inclusive, and sounds brand-preferential. IrishCowboy (talk) 23:12, 23 February 2012 (UTC)

All this talk of Heartgard and no one had added it :) I've added it. Cheers. P shadoh (talk) 19:47, 10 January 2014 (UTC)

Ivermectin Approved By FDA For Lice

See http://www.medscape.org/viewarticle/758988?src=cmemp - I don't have time to re-format the "Arthropods" section of the article. Paulburnett (talk) 21:50, 5 March 2012 (UTC)

Contraindications etc

There should be information in the article on contraindications, I'll find some info and try to add a section. Thanks. 152.38.65.133 (talk) 15:53, 20 April 2012 (UTC) Hey, it's the guy from above. I just made an account, and added some information. Hopefully, I can pull some people and information and expand the section a bit more. Cfowla (talk) 16:29, 20 April 2012 (UTC)

Untitled comments

Where does the high toxicity information come from? It contridicts the previous paragraph that states it low toxocity in mamammals and gives a contradictory LD50. I am removing the high toxicity paragraph. --Richard Arthur Norton (1958- ) 06:08, 12 January 2006 (UTC)

It comes from [1]. The keyword in that phrase is pure. As used, most avermectin formulations contain very little actual avermectin, thus the low toxicity. Pure--undiluted--avermectin is highly toxic. I will restore that paragraph. --Lensim 03:21, 15 January 2006 (UTC)

In the Use in Humans paragraph, you mention that Ivermectin can be used for "certain scabies". I thought there was one species of scabies -- how many species of scabies are there, and which ones are not affected by Ivermectin? Margaret now 13:41, 14 March 2007 (UTC)

The particular edit you reference was made by User:68.57.36.46. See also Scabies. Lensim 16:18, 14 March 2007 (UTC)

Since when is an iPod nano a credible unit of measurement? This wikipedia entry paid for by Steve Jobs?

"Soolantra" Ivermectin cream

As of December 23, 2014, an Ivermectin cream called Soolantra has apparently been approved by the FDA for rosacea, per this press release. This information should probably be put into the article in some form. —BarrelProof (talk) 00:27, 1 January 2015 (UTC)

Eradication vs treatment of river blindness

Per the Carter Center:

"The Carter Center's Onchocerciasis Elimination Program for the Americas (OEPA) works to end illness and transmission of onchocerciasis in Brazil, Ecuador, Guatemala, Mexico, Venezuela, and Colombia....

As of September 2015, a total of 11 foci of the 13 endemic areas have eliminated or interrupted transmission as a result of health education and mass drug administration (MDA) with Mectizan®. Colombia (2007) and Ecuador (2009) became the first countries in the world to halt river blindness transmission through health education and semiannual distribution of Mectizan..... Thanks to these achievements, the Americas region will soon permanently free itself from the threat of this debilitating disease.

http://www.cartercenter.org/health/river_blindness/oepa.html — Preceding unsigned comment added by 73.162.132.47 (talk) 18:06, 5 October 2015 (UTC)

History

We don't need a MEDRS compliant source for the inventorship of avermectin, as MEDRS covers biomedical information only. Per MEDRS:

"This guideline supports the general sourcing policy at Wikipedia:Verifiability with specific attention given to sources appropriate for biomedical content in any type of article, including alternative medicine. Sources for all other types of content – including all non-medical information in medicine-related articles – are covered by the general guideline on identifying reliable sources rather than this guideline.:

Historical details of individual contributions to research is not medical content.

Omura's webpage states:

"The discovery of avermectins was the result of a collaboration with Merck Sharp & Dohme Research Laboratories."

The Nobel Prize Committe Press release states that

"Satoshi Ōmura searched for bioactive substances from the soil and isolated a new microorganism (Streptomyces avermitilis) with remarkable properties. William C. Campbell identified the antiparasitic activity of Ōmura’s microbial culture and characterized the effective component, named Avermectin, against a variety of parasitic worms in domestic and farm animals."

Please don't tell me you are suggesting that the Nobel Committee didn't do its research and that the co-Laureate is lying.

Annual Reviews in Pharmacology and Toxicology, 1992, 32:537 unambiguously states:

"The avermectins were discovered in 1975 at Merck and Co... They are produced by a culture that originated in a Japanese soil sample sent by the Kitasato Institute"

There's your MEDRS source if you require one.

73.162.132.47 (talk) 00:20, 6 October 2015 (UTC)

One of the revisions introduced a lot of passive voice into it, but looks ok now. Are you sure about Campbell and Omura "discovering the avermectin family of compounds". I got the impression that was mostly Omura, and that Campbell did the extraction of avermectin after getting samples from Omura. Later research at Merck developed ivermectin, which is what pharmcos do, to improve properties and make something they can patent. ~ juanTamad (talk) 03:10, 6 October 2015 (UTC)

That's what I thought. I think this raises legitimate questions of the discovery process. Omura discovered Streptomyces avermitilis and its "remarkable properties". What were those remarkable properties? Campbell identified the "antimicrobial activities."

If, as the entry reads now, "Omura identified avermectin from the bacterium Streptomyces avermitilis," that means Omura did the biggest part of the discovery job. He discovered Streptomyces avermitilis and avermectin, and handed the cultures over to Campbell for isolation and purification. So if Omura had already identified the bacterium and the drug, what was left for Campbell to discover?

But here's a version that says Campbell discovered and named avermectin:

https://www.bostonglobe.com/metro/2015/10/05/nobel-winner-there-some-way-can-verify-this/87yPyykypdfOrkDLUoSFmJ/story.html

Stunned Nobel winner: ‘Is there some way I can verify this?’

By Eric Boodman and Helen Branswell

STAT

October 05, 2015

Omura, a microbiologist who specializes in isolating natural compounds, sent Merck soil samples for bacterial research. But the freeze-dried samples sat on a shelf in the microbiology department for a year.

When Campbell and his colleagues in the parasitology department later came up with a new method for testing potential compounds against parasitic worms, the soil samples were tested.

To his astonishment, the samples contained a compound that paralyzed parasitic worms. That substance was named avermectin, which was later modified and named ivermectin.

--Nbauman (talk) 04:48, 6 October 2015 (UTC)

@Nbauman: I'd like to apologize for the overheated language I used above.

I think there is some confusion in the press regarding the process, which a lot of laypeople don't understand. My understanding from the more sophisticated sources is that:

1) Omuara's group specialized in obtaining novel microorganizm cultures and testing them for biological actiivity. They identified the bacteria that produces avermectin and detected that the crude extract of these bacterial cultures killed parasites

2) This by itself, did not complete the "discovery" of avermectin. Biological actiivity in crude cultures may be due to substances that are simply biocides or for other reasons, would not work in vivo. The discovery process was completed at Merck, where the spectrum of activity of the crude extract ws demonstrated to be of interest, the activity in animal models was confirmed and the active molecules in the crude culture extract were isolated and their chemical structure determined.

It is my understanding from the Nobel Committee press release, Omura's website, and the Annual Reviews paper. You guys can decide how to handle this, I will not comment further. Again, sorry for getting so overheated.

73.162.132.47 (talk) 10:00, 6 October 2015 (UTC)

Brand names

Is there any reason for this long list of international brand names in the introduction? There are so many more important things about ivermectin than its brand name in Canada or Nepal. I would keep the one or two most common brand names in the introduction, and move the rest to a section headed "Marketing," if we include it at all.

It is sold under brand names Heartgard, Sklice[1] and Stromectol[2] in the United States, Ivomec worldwide by Merial Animal Health, Mectizan in Canada by Merck, Iver-DT[3] in Nepal by Alive Pharmaceutical and Ivexterm in Mexico by Valeant Pharmaceuticals International. In Southeast Asian countries, it is marketed by Delta Pharma Ltd. under the trade name Scabo 6. While in development, it was assigned the code MK-933 by Merck.[4]

(Valeant is one of the companies that buys up small-volume drugs and raises their prices, so it might be interesting to find out whether they did the same to ivermectin.) --Nbauman (talk) 00:21, 12 October 2015 (UTC)

Infobox

I have hidden the Chemical data section of the infobox because something in there is breaklng the page and causing it to fill my browser window. It appears that {{nowrap}} templates are responsible, but I can't fix the error so I'll leave the section hidden. Cheers, Baffle gab1978 (talk) 02:42, 7 May 2016 (UTC)

User:Baffle gab1978 I am not seeing the problem. Maybe User:DePiep who is the expert in these things can help. Can you post a picture of the problem you see. Doc James (talk · contribs · email) 23:56, 7 May 2016 (UTC)

No USA FDA approved medicine for worms?

After some searches it looks like the FDA has not approved any medication for deworming in Humans in the USA. The article recommends this formula, but it can only be found available for horses, dogs and cattle. It should be discussed whether formulations for other animals can be taken by Humans as last resort and what are the dangers of doing do.