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Artesunate/amodiaquine

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Artesunate/amodiaquine
Combination of
ArtesunateAntimalarial
AmodiaquineAntimalarial
Clinical data
Trade namesCamoquin, others[1]
Other namesASAQ
ATC code
Identifiers
CAS Number
ChemSpider
  • none
UNII
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Artesunate/amodiaquine, sold under the trade name Camoquin among others, is a medication used for the treatment of malaria.[3][4] It is a fixed-dose combination of artesunate and amodiaquine.[3] Specifically it recommended for acute uncomplicated Plasmodium falciparum malaria.[5] It is taken by mouth.[4]

Common side effects include loss of appetite, nausea, abdominal pain, sleepiness, trouble sleeping, and cough.[6] Safety in pregnancy is not clear; however, the medication may be used if others are not possible.[6] It is believed to be safe for use during breastfeeding.[6] Artesunate and amodiaquine are both antimalarial medication; however, work by different mechanisms.[6]

Artesunate/amodiaquine was commercially launched in 2007.[7] It is on the World Health Organization's List of Essential Medicines.[3] Artesunate/amodiaquine is available as a generic medication.[7] As of 2014 it is not commercially available in the United States or United Kingdom.[1][8]

Medical uses

Early clinical trials showed that a once-a-day dosage was effective.[9] It was subsequently clinically shown to be equally effective as artemether/lumefantrine,[10] although it is likely to be more effective in the field due to its simpler once-a-day dosage compared to artemether/lumefantrine twice-per-day dosage.

Society and culture

Artesunate/amodiaquine was commercially launched in 2007 as an affordable treatment for malaria, devised by DNDi in partnership with Sanofi-Aventis.[7] ASAQ was handed over to the MMV Access and Product Management Team in May 2015.[11]

References

  1. ^ a b Ainsworth SB (2014). "Amodiaquine with artesunate". Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. John Wiley & Sons. p. 75. ISBN 9781118819517. Archived from the original on 2016-12-20.
  2. ^ https://go.drugbank.com/drugs/DB09274
  3. ^ a b c World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  4. ^ a b Oyakhirome S, Pötschke M, Schwarz NG, Dörnemann J, Laengin M, Salazar CO, et al. (March 2007). "Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children". Malaria Journal. 6: 29. doi:10.1186/1475-2875-6-29. PMC 1831475. PMID 17352806.
  5. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 187. hdl:10665/44053. ISBN 9789241547659.
  6. ^ a b c d "Artesunate Amodiaquine Winthrop" (PDF). WIPO. August 2010. Archived (PDF) from the original on 24 October 2016. Retrieved 12 December 2016.
  7. ^ a b c "New, Once-a-Day Fixed-Dose Combination Against Malaria Now Available – DNDi". www.dndi.org. 1 March 2007. Archived from the original on 20 December 2016. Retrieved 12 December 2016.
  8. ^ Rosenthal PJ, Kamya M (2015). "Malaria". In Goldman L, Schafer AI (eds.). Goldman-Cecil Medicine. Elsevier Health Sciences. p. 2112. ISBN 9780323322850. Archived from the original on 2016-12-20.
  9. ^ Ndiaye JL, Randrianarivelojosia M, Sagara I, Brasseur P, Ndiaye I, Faye B, et al. (June 2009). "Randomized, multicentre assessment of the efficacy and safety of ASAQ--a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria". Malaria Journal. 8: 125. doi:10.1186/1475-2875-8-125. PMC 2698916. PMID 19505304.
  10. ^ Ndiaye JL, Faye B, Gueye A, Tine R, Ndiaye D, Tchania C, et al. (August 2011). "Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial". Malaria Journal. 10: 237. doi:10.1186/1475-2875-10-237. PMC 3171378. PMID 21838909.
  11. ^ "DNDi passes the ball to MMV | Medicines for Malaria Venture". www.mmv.org. 22 May 2015. Retrieved 2020-02-13.
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