Broca's area
| Broca's area | |
|---|---|
 Approximate location of Broca's area highlighted in gray | |
 Broca's area visible but not labeled. | |
| Details | |
| Part of | Frontal lobe |
| Artery | Middle cerebral |
| Vein | Superior sagittal sinus |
| Identifiers | |
| MeSH | D065711 |
| NeuroNames | 2062 |
| FMA | 242176 |
| Anatomical terms of neuroanatomy | |
Broca's area is a region of the brain responsible for speech production.
The importance of Broca’s area in producing language has been recognized since Paul Pierre Broca reported impairments in two patients he encountered. They had lost the ability to speak after injury to the posterior inferior frontal gyrus of the brain.[1] Since then, the approximate region he identified has become known as Broca’s area, and the deficit in language production as Broca’s aphasia. Broca’s area is now typically defined in terms of the pars opercularis and pars triangularis of the inferior frontal gyrus, represented in Brodmann’s cytoarchitectonic map as areas 44 and 45.[1] Studies of chronic aphasia have implicated an essential role of Broca’s area in various speech and language functions. Further, functional MRI studies have also identified activation patterns in Broca’s area associated with various language tasks.
Anatomy and Connectivity
Broca's area is often identified by visual inspection of the topography of the brain either by macrostructural landmarks such as sulci or by the specification of coordinates in a particular reference space. The currently used Talairach and Tournoux atlas projects Brodmann's cytoarchitectonic map on to a template brain. Because Brodmann's parcelation was based on subjective visual inspection of cytoarchitectonic borders and also Brodmann analyzed only one hemisphere of one brain, the result is imprecise. Further, because of considerable variability across brain in terms of shape, size, and position relative to sulcal and gyral structure, a resulting localization precision is limited.[2]
Nevertheless, Broca’s area in the left hemisphere and its homologue in the right hemisphere are designations usually used to refer to pars triangularis (PTr) and pars opercularis (POp) of the inferior frontal gyrus. The PTr and POp are defined by structural landmarks that only probabilistically divide the inferior frontal gyrus into anterior and posterior cytoarchitectonic areas of 45 and 44, respectively, by Brodmann’s classification scheme.[3]
Area 45 receives more afferent connections from prefrontal cortex, the superior temporal gyrus, and the superior temporal sulcus, compared to area 44, which tends to receive more afferent connections from motor, somatosensory, and inferior parietal regions.[3]
The differences between area 45 and 44 in cytoarchitecture and in connectivity suggest that these areas might perform different functions. Indeed, recent neuroimaging studies have shown that the PTr and Pop, coressponding to areas 45 and 44, respectively, play different functional roles in the human with respect to language comprehension and action recognition/understanding.[3]
Broca's Area Revisited
In a recent study, the preserved brains of both Leborgne and Lelong (patients of Paul Pierre Broca) were reinspected using high-resolution volumetric MRI. The purpose of this study was to scan the brains in three dimensions and to identify the extent of both cortical and subcortical lesions in more detail. The study also sought to locate the exact site of the lesion in the frontal lobe in relation to what is now called Broca's area with the extent of subcortical involvement.[1]
Broca's Patients
Leborgne
Leborgne was a patient of Paul Pierre Broca. He was unable to produce any words or phrases. The only word he could repetitively produce was 'tan'. After his death, a lesion was discovered on the surface of the left frontal lobe.
Lelong
Lelong was another patient of Paul Pierre Broca. He also exhibited reduced productive speech. He could only say five words, 'yes,' 'no,' 'three,' 'always,' and 'lelo' (a mispronunciation of his own name). At autopsy, a lesion was also found in the same region of lateral frontal lobe as in Leborgne. These two cases led Paul Pierre Broca to believe that the localization of speech to this particular area.
MRI Findings
Examination of the brains of Paul Pierre Broca's two historic patients with high resolution MRI has produced several interesting findings. First, the MRI findings suggest that other areas besides Broca's area may also have contributed to the patients' reduced productive speech. This finding is significant because it has been found that though lesions to Broca's area alone can possibly cause temporary speech disruption, they do not result in severe speech arrest. Therefore, there is a possibility that the aphasia denoted by Broca as an absence of productive speech also could have been influenced by the lesions in the other region. Another interesting finding is that the lesion, which was once considered to be critical for speech by Broca, is not precisely the same region as what is now known as Broca's area. This study provides further evidence that language and cognition are far more complicated than once thought and involve various networks of brain regions.
Functions
Language Comprehension
For a long time, it was assumed that the role of Broca's area was more devoted to language production than language comprehension. However, recent evidence demonstrates that Broca's area also plays a significant role in language comprehension. Patients with lesions in Broca's area who exhibit agrammatical speech production also show inability to use syntactic information to determine the meaning of sentences.[4] Also, a number of neuroimaging studies have implicated an involvement of Broca's area, particularly of the pars opercularis of the left inferior frontal gyrus, during the processing of complex sentences.[5] Further, it has been recently found in functional magnetic resonance imaging (fMRI) experiments involving highly ambiguous sentences result in more activated inferior frontal gyrus.[3] Therefore, activity level in inferior frontal gyrus and the level of lexical ambiguity are directly proportional to each other, because of the increased retrieval demands associated with highly ambiguous content.
Action Recognition and Production
Recent experiments have indicated that Broca's area is involved in various cognitive and perceptual task. One important contribution of Brodmann's area 44 is also found in the motor-related processes. Observation of meaningful hand shadows resembling moving animals activates frontal language area, demonstrating that Broca's area indeed plays a role in interpreting action of others.[6] An activation of BA 44 was also reported during execution of grasping and manipulation.[7]
Speech-Associated Gestures
It has been speculated that because speech-associated gestures could possibly reduce lexical or sentential ambiguity, comprehension should improve in the presence of speech-associated gestures. As a result of improved comprehension, the involvement of Broca's area should be reduced.[3]
Many neuroimaging studies have also shown activation of Broca's area when representing meaningful arm gestures. A recent study has shown evidence that word and gesture are related at the level of translation of particular gesture aspects such as goal and intention.[8] This finding that aspects of gestures are translated in words within Broca's area also explains language development in terms of evolution. Indeed, many authors have proposed that speech evolved from a primitive communication that arose from gestures.[6],[9] (see Evolution of Language below)
Aphasia
Definition
"Aphasia is an acquired language disorder affecting all modalities such as writing, reading, speaking, and listening and results from brain damage. It is often a chronic condition that creates changes in all areas of one’s life."
From the interview with Dr. Jacqueline Laures-Core, an Assistant Profesor of Communication Disorders at Georgia State University and co-president of Atlanta Aphasia Association[10]
Broca's Aphasia vs. Other Aphasia
Patients' with Broca's aphasia are individuals who know "what they want to say, they just cannot get it out." [10] They are typically able to understand what is being said to them, but unable to fluently speak. This is also known as non-fluent aphasia. Some of other symptoms may include problems with fluency, articulation, word-finding, repetition, and producing and comprehending complex grammatical sentences, both orally and in writing.[1] These characteristics distinguish them from other individuals with other types of aphasia. Other aphasia types may have more difficulty with understand what is said to them. They may also struggle more with reading and writing than do individuals with Broca’s aphasia. While the individuals with Broca’s aphasia also have a good ability to self-monitor their language output, other types of aphasia may be more unaware of their language performance. Also, site of lesion (brain damaged area) differs between the different aphasias.
Table 1. Major Characteristics of Different Types of Aphasia[10]
| Type of Aphasia | Repetition | Naming | Auditory Comprehension | Fluency |
|---|---|---|---|---|
| Broca's | Mod-severe | Mod-severe | Mild difficulty | Non-fluent, effortful, slow |
| Wernicke's | Mild-severe | Mild-severe | Defective | Fluent paraphasic |
| Conduction | Poor | Poor | Relatively good | Fluent |
| Mixed Transcortical | Moderate | Poor | Poor | Non-fluent |
| Transcortical Motor | Good | Mild-severe | Mild | Non-fluent |
| Transcortical Sensory | Good | Mod-severe | Poor | Fluent |
| Global | Poor | Poor | Poor | Non-fluent |
| Anomic | Mild | Mod-severe | Mild | Fluent |
Case Study
Broca’s area is located in the left posterior inferior front cortex comprising of Brodmann’s area 44 and 45. It is responsible for speech production, language processing, and language comprehension. In this study, it was hypothesized that language functions are dependent on Broca’s area; and will therefore be impaired when the neural tissue within Broca’s area is selectively hypoperfused. As evidence for the hypothesis, a variety of language functions in a patient with hyperacute stroke, exhibiting selective hypoperfusion with minimal infarct in Broca’s area was studied. MRI scans including diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI) showed a very small infarct in the left posterior frontal lobe, surrounded by a much larger perfusion deficit in the region.[11]
The language tests were administered 5 hours before and 32 hours after restoring function of Broca’s area. Some of the language tests included: 1) oral and written naming, 2) oral reading, 3) spelling to dictation, and 4) repetition. As a control, the median score obtained from 50 neurologically normal subjects on the same language tests was used to compare with the patient’s score. It was reported that the median score for the normal subjects was 100% correct; and no one scored below 90%. Prior to the treatment to restore the function of Broca’s area, the patient scored normally on simple auditory questions, oral reading, and repetition. However, he performed poorly on other languages tests such as oral naming and spelling. Then, he was treated with intravenous saline to increase his blood pressure, which in turn, improved blood flow to the area of cortex to restore function of Broca’s area. Further, PWI was used to show complete reperfusion of Broca’s area. When the language tests were administered again 32 hours after the treatment, it was found that he scored normal or above average levels on all language tasks.[11]
The hypothesis that sufficient function of Broca’s area was necessary for a variety of language comprehension and production tasks was confirmed. In addition, as seen in this patient, restoration of normal blood flow to the Broca’s area resulted in rapid recovery of these functions. Therefore, this study clearly demonstrates that Broca’s area plays an essential role in oral naming and spelling; auditory active and passive sentences; written active and passive sentences; and finally, motor planning and programming of speech articulation.[11]
Evolution of Language
Several models have been proposed to explain the origin of human language. Human language is thought to have evolved as the “evolutionary refinement of an implicit communication system, already present in lower primates, based on a set of hand/mouth goal-directed action representations.”[6] The recent finding that Broca’s area is involved during meaningful action observation supports this idea. It was hypothesized that Broca’s area precursor was involved in generating action meanings by interpreting motor sequences in terms of goal. It was further argued that this ability might have been generalized during the evolution that gave this area the capability to deal with meanings. The activated frontal language areas when observing meaningful hand shadows resembling moving animals provides evidence that the human language may have evolved from neural substrates already involved in gestural recognition. Therefore, the study has demonstrated human Broca’s area as the motor center for speech, assembling and decoding communicative gestures. Consistent with this idea is that the neural substrate that regulated motor control in the common ancestor of apes and humans was most likely modified to enhance cognitive and linguistic ability.[9]
Another recent finding has showed significant areas of activation in subcortical and neocortical areas during the production of communicative manual gestures and vocal signals in chimpanzees.[12] Further, the data indicating that chimpanzees intentionally produce manual gestures as well as vocal signals to communicate with humans suggests that the precursors to human language are present at both the behavioral and neuronanatomical levels.
See also
References
- ^ a b c d N. F. Dronkers, O. Plaisant, M. T. Iba-Zizen, and E. A. Cabanis (2007). "Paul Broca's Historic Cases: High Resolution MR Imaging of the Brains of Leborgne and Lelong". Brain. 130: 1432-1441. doi:10.1093/brain/awm042. PMID 17405763.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yosef Grodzinsky and Andrea Santi (2002). "The Battle for Broca's Region". Trends in Cognitive Sciences. 12 (12): 474-480. doi:10.1016/j.tics.2008.09.001. PMID 18930695.
- ^ a b c d e Jeremy I. Skipper, Susan Goldin-Meadow, Howard C. Nusbaum, and Steven L. Small (2007). "Speech-Associated Gestures, Broca's Area, and the Human Mirror System". Brain and Language. 101: 260-277. doi:10.1016/j.bandl.2007.02.008. PMID 17533001.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ David Caplan (2006). "Why is Broca's Area Involved in Syntax?". Cortex. 42: 469-471. PMID 16881251.
- ^ Tanja Crewe, Ina Bornkessel, Stefan Zysset, Richard Wiese, D. Yves von Cramon, and Matthias Schlesewksy (2005). "The Emergence of the Unmarked: A New Perspective on the Language-Specific Function of Broca's Area". Human Brain Mapping. 26: 178-190. doi:10.1002/hbm.20154. PMID 15929098.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b c Luciano Fadiga, Laila Craighero, Maddalena Fabbri Destro, Livio Finos, Nathalie Cotilon-Williams, Andrew T. Smith, and Umberto Castiello (2006). "Language in Shadow". Social Neuroscience. 1 (2): 77-89. doi:10.1080/17470910600976430. PMID 18633777.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Luciano Fadiga and Laila Craighero (2006). "Hand Actions and Speech Representation In Broca's Area". Cortex. 42: 486-490. PMID 16881255.
- ^ Maurizio Gentilucci, Paolo Bernardis, Girolamo Crisi, and Riccardo Dalla Volta (2006). "Repetitive Transcranial Magnetic Stimulation of Broca's Area Affects Verbal Responses to Gesture Observation". Journal of Cognitive Neuroscience. 18 (7): 1059-1074. doi:10.1162/jocn.2006.18.7.1059. PMID 16839281.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Philip Lieberman (2002). "On the Nature and Evolution of the Neural Bases of Human Language". Yearbook of Physical Anthropology. 45: 36-62. PMID 12653308.
- ^ a b c "What is Aphasia". Atlanta Aphasia Association. 2006. Retrieved 2008-12-01.
- ^ a b c Cameron Davis, Jonathan T. Kleinman, Melissa Newhart, Leila Gingis, Mikolaj Pawlak, and Argye E. Hillis (2008). "Speech and Language Functions that Require a Functioning Broca's Area". Brain and Language. 105: 50-58. doi:10.1016/j.bandl.2008.01.012. PMID 18325581.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Jared P. Taglialatela, Jamie L. Russell, Jennifer A. Schaeffer, and William D. Hopkins (2008). "Communicative Signaling Activates 'Broca's' Homolog in Chimpanzees". Current Biology. 18: 343-348. doi:10.1016/j.cub.2008.01.049. PMID 18308569.
{{cite journal}}: CS1 maint: multiple names: authors list (link)