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Neuroblastoma

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Neuroblastoma
SpecialtyOncology Edit this on Wikidata
Sympathetic nervous system

Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy, with an annual incidence of about 650 new cases per year in the US.[1] Close to 50 percent of neuroblastoma cases occur in children younger than two years old.[2] It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system or SNS. A branch of the autonomic nervous system, the SNS is a nerve network that carries messages from the brain throughout the body and is responsible for the fight-or-flight response and production of adrenaline or epinephrine. Its solid tumors, which take the form of a lump or mass, commonly begin in one of the adrenal glands, though they can also develop in nerve tissues in the neck, chest, abdomen, or pelvis. Esthesioneuroblastoma, also known as olfactory neuroblastoma, is believed to arise from the olfactory epithelium and classification remains controversial. Since it is not a sympathetic nervous system malignancy it is a distinct clinical entity not to be confused with neuroblastoma.[3][4]

Neuroblastoma is one of the rare human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance.[5]

Epidemiology

Neuroblastoma comprises 6-10% of all childhood cancers, and 15% of cancer deaths in children. The annual mortality rate is 10 per million children in the 0- to 4-year-old age group, and 4 per million in the 4- to 9-year old age group.[6]

The highest incidence is in the first year of life, and some cases are congenital. The age range is broad, including older children and adults,[7] but only 10% of cases occur in people older than 5 years of age.[8] A large European study reported less than 2% of over 4000 neuroblastoma cases were over 18 years old.[9]

Etiology

The etiology of neuroblastoma is not well understood. Several risk factors have been proposed and are the subject of ongoing research. Due to characteristic early onset many studies have focused on parental factors around conception and during gestation. Factors investigated have included occupation (i.e. exposure to chemicals in specific industries), smoking, alcohol consumption, use of medicinal drugs during pregnancy and birth factors, however results have been inconsistent.[10]

Other studies have examined possible links with atopy and exposure to infection early in life,[11] use of hormones and fertility drugs,[12] and maternal use of hair dye.[13][14]

Familial neuroblastoma is very rare, and germline mutations in the anaplastic lymphoma kinase (ALK) gene are linked to most hereditary neuroblastomas.[15]

Diagnosis

MRI showing orbital and skull vault metastatic NB in 2 year old

The first symptoms of neuroblastoma are often vague and may include fatigue, loss of appetite, and fever. Later symptoms depend on tumor locations:[16]

Often because symptoms are so unclear, 50 to 60% of all neuroblastomas have already spread (metastasized) to other parts of the body by the time a diagnosis is made.[17]

The diagnosis is usually confirmed by a surgical pathologist, taking into account the clinical presentation, microscopic findings, and other laboratory tests. On microscopy, the tumor cells are typically described as small, round and blue, and rosette patterns (Homer-Wright pseudo-rosettes) may be seen.[18] A variety of immunohistochemical stains are used by pathologists to distinguish neuroblastomas from histological mimics, such as rhabdomyosarcoma, Ewing's sarcoma, lymphoma and Wilms' tumor. In February 2007, Althea Technologies announced the development of a molecular diagnostic capable of clearly differentiating various types of childhood cancers, developed in cooperation with the U.S. National Cancer Institute (NCI).[19]

In about 90% of cases of neuroblastoma, elevated levels of catecholamines or its metabolites are found in the urine or blood. Catecholamines and their metabolites include dopamine, homovanillic acid (HVA), and/or vanillylmandelic acid (VMA).[20]

Another way to detect neuroblastoma is the mIBG scan (meta-iodobenzylguanidine), which is taken up by 90 to 95% of all neuroblastomas, often termed "mIBG-avid."[8] The mechanism is that mIBG is taken up by sympathetic neurons, and is a functioning analog of the neurotransmitter norepinephrine. When it is radio-ionated with I-131 or I-123 (radioactive iodine isotopes), it is a very good radiopharmaceutical for diagnosis and monitoring of response to treatment for this disease. With a half-life of 13 hours, I-123 is the preferred isotope for imaging sensitivity and quality. I-131 has a half-life of 8 days and at higher doses is an effective therapy as targeted radiation against relapsed and refractory neuroblastoma.[21]

Histology

microscopic view of stroma-rich ganglioneuroblastoma

Neuroblastoma is one of the peripheral neuroblastic tumors (pNTs) that have similar origins and show a wide pattern of differentiation ranging from benign ganglioneuroma to stroma-rich ganglioneuroblastoma with differentiating neuroblastic cells intermixed or in nodules, to highly malignant neuroblastoma. This distinction in the pre-treatment tumor pathology is an important prognostic factor, along with age and mitosis-karyorrhexis index (MKI). This pathology classification system describes "favorable" and "unfavorable" tumors by the International Neuroblastoma Pathology Committee (INPC, also called Shimada system) which was established in 1999 and revised in 2003.[22]

Stage and risk assignment

The "International Neuroblastoma Staging System" (INSS) established in 1986 and revised in 1988 stratifies neuroblastoma according to its anatomical presence at diagnosis:[23][24][25]

  • Stage 1: Localized tumor confined to the area of origin.
  • Stage 2A: Unilateral tumor with incomplete gross resection; identifiable ipsilateral and contralateral lymph node negative for tumor.
  • Stage 2B: Unilateral tumor with complete or incomplete gross resection; with ipsilateral lymph node positive for tumor; identifiable contralateral lymph node negative for tumor.
  • Stage 3: Tumor infiltrating across midline with or without regional lymph node involvement; or unilateral tumor with contralateral lymph node involvement; or midline tumor with bilateral lymph node involvement.
  • Stage 4: Dissemination of tumor to distant lymph nodes, bone marrow, bone, liver, or other organs except as defined by Stage 4S.
  • Stage 4S: Age <1 year old with localized primary tumor as defined in Stage 1 or 2, with dissemination limited to liver, skin, or bone marrow (less than 10 percent of nucleated bone marrow cells are tumors).

Although international agreement on staging (INSS) has been used, the need for an international consensus on risk assignment has also been recognized in order to compare similar cohorts in results of studies. Beginning in 2005, representatives of the major pediatric oncology cooperative groups have met to review data for 8,800 neuroblastoma patients treated in Europe, Japan, USA, Canada, and Australia between 1990 and 2002. This task force has proposed the International Neuroblastoma Risk Group (INRG) classification system. Retrospective studies revealed the high survival rate of 12-18 month old age group, previously categorized as high-risk, and prompted the decision to reclassify 12-18 month old children without MYCN amplification to intermediate risk category.[26]

The new INRG risk assignment will classify neuroblastoma at diagnosis based on a new International Neuroblastoma Risk Group Staging System (INRGSS):

  • Stage L1: Localized disease without image-defined risk factors.
  • Stage L2: Localized disease with image-defined risk factors.
  • Stage M: Metastatic disease.
  • Stage MS: Metastatic disease "special" where MS is equivalent to stage 4S.

The new risk stratification will be based on the new INRGSS staging system, age (dichotomized at 18 months), tumor grade, MYCN amplification, unbalanced 11q aberration, and ploidy into four pre-treatment risk groups: very low, low, intermediate, and high risk.[27][28]

Cytogenetic Profiles and Outcome

Based on a series of 493 neuroblastoma samples, it has been reported that overall genomic pattern, as tested by array-based karyotyping, is a predictor of outcome in neuroblastoma[29]:

  • Tumors presenting exclusively with whole chromosome copy number changes were associated with excellent survival.
  • Tumors presenting with any kind of segmental chromosome copy number changes were associated with a high risk of relapse.
  • Within tumors showing segmental alterations, additional independent predictors of decreased overall survival were MYCN amplification, 1p and 11q deletions, and 1q gain.

Earlier publications categorized neuroblastomas into three major subtypes based on cytogenetic profiles[30]:

  • Subtype 1: favorable neuroblastoma with near triploidy and a predominance of numerical gains and losses, mostly representing non-metastatic NB stages 1, 2 and 4S.
  • Subtypes 2A and 2B: found in unfavorable widespread neuroblastoma, stages 3 and 4, with 11q loss and 17q gain without MYCN amplification (subtype 2A) or with MYCN amplification often together with 1p deletions and 17q gain (subtype 2B).

Virtual karyotyping can be performed on fresh or paraffin-embedded tumors to assess copy number at these loci. SNP array virtual karyotyping is preferred for tumor samples, including neuroblastomas, because they can detect copy neutral loss of heterozygosity (acquired uniparental disomy). Copy neutral LOH can be biologically equivalent to a deletion and has been detected at key loci in neuroblastoma.[31] ArrayCGH, FISH, or conventional cytogenetics cannot detect copy neutral LOH.

Screening

Urine catecholamine level can be elevated in pre-clinical neuroblastoma. Screening asymptomatic infants at three weeks, six months, and one year has been performed in Japan, Canada, and Germany since the 1980s.[32][33] Japan began screening six-month olds for neuroblastoma via analysis of the levels of homovanillic acid and vanilmandelic acid in 1984. Screening was halted in 2004 after studies in Canada and Germany showed no reduction in deaths due to neuroblastoma, but rather caused an increase in diagnoses that would have disappeared without treatment, subjecting those infants to unnecessary surgery and chemotherapy.[34][35] [36]

Treatment

Current

When the lesion is localized, it is generally curable. However, long-term survival for children with advanced disease older than 18 months of age is poor despite aggressive multimodal therapy (intensive chemotherapy, surgery, radiation therapy, stem cell transplant, differentiation agent isotretinoin also called 13-cis-retinoic acid, and frequently immunotherapy[37] with anti-GD2 monoclonal antibody therapy).

Biologic and genetic characteristics have been identified, which, when added to classic clinical staging, has allowed patient assignment to risk groups for planning treatment intensity.[38] These criteria include the age of the patient, extent of disease spread, microscopic appearance, and several other biological features, most importantly MYCN oncogene amplification (MYCN regulates microRNAs[39]), into low, intermediate, and high risk disease. A recent biology study (COG ANBL00B1) analyzed 2687 neuroblastoma patients and the spectrum of risk assignment was determined: 37% of neuroblastoma cases are low risk, 18% are intermediate risk, and 45% are high risk.[40] (There is some evidence that the high- and low-risk types are caused by different mechanisms, and are not merely two different degrees of expression of the same mechanism.)[41]

The therapy for these different risk categories is very different.

With current treatments, patients with low and intermediate risk disease have an excellent prognosis with cure rates above 90% for low risk and 70%-90% for intermediate risk. In contrast, therapy for high-risk neuroblastoma results in cures only about 30% of the time.[45]

Chemotherapy agents used in combination have been found to be effective against neuroblastoma. Agents commonly used in induction and for stem cell transplant conditioning are platinum compounds (cisplatin, carboplatin), alkylating agents (cyclophosphamide, ifosfamide, melphalan), topoisomerase II inhibitor (etoposide), anthracycline antibiotics (doxorubicin) and vinca alkaloids (vincristine). Some newer regimens include topoisomerase I inhibitors (topotecan and irinotecan) in induction which have been found to be effective against recurrent disease.

Clinical trials for new frontline treatments

Recent focus has been to reduce therapy for low and intermediate risk neuroblastoma while maintaining survival rates at 90%.[46] A study of 467 intermediate risk patients enrolled in A3961 from 1997 to 2005 confirmed the hypothesis that therapy could be successfully reduced for this risk group. Those with favorable characteristics (tumor grade and response) received four cycles of chemotherapy, and those with unfavorable characteristics received eight cycles, with three-year event free survival and overall survival stable at 90% for the entire cohort. Future plans are to intensify treatment for those patients with aberration of 1p36 or 11q23 chromosomes as well as for those who lack early response to treatment.[47]

By contrast, focus the past 20 years or more has been to intensify treatment for high-risk neuroblastoma. Chemotherapy induction variations, timing of surgery, stem cell transplant regimens, various delivery schemes for radiation, and use of monoclonal antibodies and retinoids to treat minimal residual disease continue to be examined. Recent phase III clinical trials with randomization have been carried out to answer these questions to improve survival of high-risk d.

  • 1982-1985: European Neuroblastoma Study Group (ENSG1) enrolled 167 children and randomized to melphalan autologous bone marrow transplant or no further therapy (no radiation therapy given to any). Transplant and no-transplant arms each had 65 patients, and recent long-term follow-up report revealed significantly better 5 year event-free survival for stage 4 over 1 year old in melphalan-transplant group versus no further treatment: 33% versus 17% respectively.[48]
  • 1990-1999: European study (EU-20592 or CCLGNB-1990-11) randomized 262 high-risk children over 1 year old and revealed higher survival rate for rapid sequence induction (10-day cycle) versus standard induction (21-day cycle) with same total dose. Ten-year event free survival was 27% and 18% respectively with non-aggressive surgical approach, no radiotherapy, and melphalan-only autologous bone marrow or stem cell transplant for both groups.[49]
  • 1991-1996: Phase III trial with two sequential randomizations for 379 high-risk NB patients was carried out by the Children's Cancer Group (CCG-3891) which demonstrated improved survival with myeloablative therapy (with total body irradiation) and 13-cis-retinoic acid (Accutane) with 50 patients in each of the four arms of the study.[50],[51]
  • 1996-2003: The German (GPOH) study NB97 compared outcomes of 295 high-risk NB patients randomized for stem cell transplant or consolidation chemotherapy. Results showed increased survival with transplant.[52]
  • 2000-2006: The recent study (COG-A3973)[[#cite_note-titleClinical_Trials_(PDQ�)_-_National_Cancer_Institute-53|[53]]] questioned the need for purged stem cells for CEM-LI (carboplatin, etoposide, melphalan, with local irradiation)[54] transplant, and accrued 486 patients. Purging stem cells was not found to improve survival[55]
  • 2000-2012: An additional study (COG-ANBL0032)[56] determined that the antibody ch14.18 with interleukin 2 and GMCSF (studied retrospectively in German GPOH NB90 and NB 97 at a lower dose and without cytokines[57]) improved survival, and will accrue a total of 423 patients.[58]
  • 2002-2008: SIOP (International Society of Paediatric Oncology) formed the European SIOP Neuroblastoma Group (ESIOP NB) in 1994 [59] and activated a phase III high-risk NB protocol in 2002 (SIOP-EUROPE-HR-NBL-1) [60] using “rapid” COJEC (8 cycles of chemotherapy given at 10-day intervals) followed by transplant randomization to CEM (carboplatin, etoposide, melphalan) or BuMel (busulfan, melphalan) and then randomization to with or without ch14.18 antibody treatment. This study will evaluate the use of growth factors as well as compare transplant regimens, with or without ch14.18 antibody, and all patients receive retinoic acid. This trial will accrue 1000 patients (175 per year). There are eight arms to this study.
  • 2005-2010: The current German NB2004 [61] randomization will include MIBG therapy and randomize topotecan use in up-front therapy and will accrue a total of 642 for all risk groups (roughly half will be high-risk). After transplant, the high-risk protocol includes six months of cis-retinoic acid, a three month break, and another three months of retinoic acid.
  • 2007: The COG phase III ANBL0532 [62] trial opened December 2007 for accrual of 495 and will compare single versus tandem transplants, and induction begins with two cycles of topotecan.[63]

In addition to these phase III studies, research institutions such as Baylor College of Medicine/Texas Children's, St. Jude Children's Research Hospital (Memphis, Tennessee), and Memorial Sloan-Kettering Cancer Center in New York offer unique treatment protocols. Texas Children's uses a novel induction regimen which includes a method of giving chemotherapy called “chemo-switching” where cisplatin is given as high-dose pulse and etoposide is given at low-dose over several weeks for the first two cycles.[64] St Jude's recently finished (2007) testing a new up-front chemotherapy regimen in 23 children which included irinotecan and gefitinib with 16 months of maintenance chemotherapy after stem cell transplant with alternating oral 13-cis-retinoic acid and topotecan.[65] In December 2008 St Jude's opened a new trial using temsirolimus and irinotecan in induction.[66] Sloan-Kettering offers treatment that includes a mouse-derived monoclonal antibody, 3F8, used in protocols since the mid 1980s. This antibody is used for treating minimal residual disease or consolidation instead of stem cell transplant.[67]

Clinical trials for refractory and relapsed neuroblastoma

microscopic view of a NB cell line (SH-SY5Y) used in preclinical research for testing new agents

Some children (particularly in high-risk cases) do not respond completely to frontline treatment (with a complete response or very good partial response) and are labeled refractory. These children are removed from the frontline therapy (clinical trial) and are eligible for clinical trials using new therapies. Many high-risk children have a good response to frontline therapy and achieve a remission, but later the disease recurs (relapse). These children are also eligible for new therapies being tested in clinical trials. The protein p53 is believed to play a role in the development of resistance to chemotherapy.[68]

Chemotherapy with topotecan and cyclophosphamide is frequently used in refractory setting and after relapse. A randomized study (2004) with 119 patients (comparing topotecan alone to topotecan and cyclophosphamide) revealed a 31% complete or partial response rate with two-year progression-free survival at 36% in the topotecan and cyclophosphamide group.[69] Irinotecan (intravenous or oral) and oral temozolomide are also used in refractory and recurrent neuroblastoma.[70][71]

Many phase I and phase II trials are currently testing new agents against neuroblastoma in children who have relapsed or are resistant to initial therapy. Investigators are studying targeted therapy, anti-angiogenesis agents, and new monoclonal antibodies such as hu14.18-IL2.

In November 2006, DRAXIS Health received approval from the U.S. Food and Drug Administration (FDA) to run two clinical trials using radioactive Iobenguane I-131 Injection (I-131 MIBG) to treat high-risk neuroblastoma[72] and in May 2008 Molecular Insight Pharmaceuticals announced the opening of a Phase IIa trial of Azedra, the I-131 MIBG molecule radiolabeled using Molecular Insight's proprietary Ultratrace technology, which removes unnecessary nonradioactive molecules, effectively concentrating radiation in the neuroblastoma tumor cells.[73][74][75] These trials are coordinated by a group of 11 children’s hospitals and two universities in the United States known as the New Advances in Neuroblastoma Therapy (NANT) consortium, and are continuations of earlier NANT studies. The NANT consortium is also currently offering trials using a tyrosine kinase inhibitor CEP-701 (lestaurtinib), new oral powder formulation of fenretinide, intravenous fenretinide, and bisphosphonate (Zometa).[76]

In February 2007, a study in Sweden reported that a common painkiller, might inhibit the development of neuroblastoma and help make treatment of the disease more effective. Celecoxib, an analgesic, anti-inflammatory substance that works by inhibiting the effect of the inflammatory enzyme, Cox-2, and thus could affect neuroblastoma tumors, which depend on Cox-2 for their growth and proliferation. Clinical studies are now planned; research to date has been done only in animals and cell cultures.[77][78]

Post-treatment prognosis and late-effects

Neuroblastoma frequently recurs in high-risk cases. Further treatment is available in phase I and phase II clinical trials that test new agents and combinations of agents against neuroblastoma, but the outcome remains very poor for relapsed high-risk disease.[79]

Most long-term survivors alive today had low or intermediate risk disease and milder courses of treatment compared to high-risk disease. The majority of survivors have long-term effects from the treatment. Survivors of intermediate and high-risk treatment often experience hearing loss. Growth reduction, thyroid function disorders, learning difficulties, and greater risk of secondary cancers affect survivors of high-risk disease.[80][81] An estimated two of three survivors of childhood cancer will ultimately develop at least one chronic and sometimes life-threatening health problem within 20 to 30 years after the cancer diagnosis.[82][83]

References

  1. ^ "eMedicine - Neuroblastoma : Article by Norman J Lacayo, MD". Retrieved 2008-07-30.
  2. ^ Janet Sassi, "Cellular Communication: Unraveling the Secrets of Histone Proteins", Fordham University, February 16, 2007
  3. ^ "eMedicine - Esthesioneuroblastoma : Article by Pavel Dulguerov, MD". Retrieved 2008-07-30.
  4. ^ Cheung, Nai-Kong (2005). Neuroblastoma. p. 73. Springer-Verlag. ISBN 10 3-540-40841-X. {{cite book}}: Check |isbn= value: length (help)
  5. ^ Bénard J, Raguénez G, Kauffmann A; et al. (2008). "MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: a molecular portrait of stage 4S". Mol Oncol. 2 (3): 261–71. doi:10.1016/j.molonc.2008.07.002. PMID 19383347. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. ^ Brodeur GM, Castleberry RP. Neuroblastoma. In: Pizzo PA, Poplack DG. Principles and practice of pediatric oncology, 3rd ed. 1997:761-797.
  7. ^ Franks LM, Bollen A, Seeger RC, Stram DO, Matthay KK (1997). "Neuroblastoma in adults and adolescents: an indolent course with poor survival". Cancer. 79 (10): 2028–35. PMID 9149032.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ a b Howman-Giles R, Shaw PJ, Uren RF, Chung DK (2007). "Neuroblastoma and other neuroendocrine tumors". Semin Nucl Med. 37 (4): 286–302. doi:10.1053/j.semnuclmed.2007.02.009. PMID 17544628.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Ladenstein R, Pötschger U, Hartman O; et al. (2008). "28 years of high-dose therapy and SCT for neuroblastoma in Europe: lessons from more than 4000 procedures". Bone Marrow Transplant. 41 Suppl 2: S118–27. doi:10.1038/bmt.2008.69. PMID 18545256. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  10. ^ Olshan, AF, Bunin, GR (2000) Epidemiology of Neuroblastoma. In: Brodeur, GM, Sawada, T, Tsuchida, Y, Voute, PA eds. , Neuroblastoma, Elsevier, Amsterdam, pp 33-39. ISBN 044450222X [1]
  11. ^ Menegaux F, Olshan AF, Neglia JP, Pollock BH, Bondy ML (2004). "Day care, childhood infections, and risk of neuroblastoma". Am. J. Epidemiol. 159 (9): 843–51. doi:10.1093/aje/kwh111. PMC 2080646. PMID 15105177. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  12. ^ Olshan AF,et al. "Hormone and Fertility Drug Use and the Risk of Neuroblastoma: A Report from the Children's Cancer Group and the Pediatric Oncology Group", Am J Epidemiol 1999;150:930-8.
  13. ^ ,McCall EE,et al. "Maternal hair dye use and risk of neuroblastoma in offspring", Cancer Causes and Control 2005; 16,6:743-8
  14. ^ Heck JE, Ritz B, Hung RJ, Hashibe M, Boffetta P (2009). "The epidemiology of neuroblastoma: a review". Paediatr Perinat Epidemiol. 23 (2): 125–43. doi:10.1111/j.1365-3016.2008.00983.x. PMID 19159399. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  15. ^ Mossé YP, Laudenslager M, Longo L; et al. (2008). "Identification of ALK as a major familial neuroblastoma predisposition gene". Nature. 455 (7215): 930–5. doi:10.1038/nature07261. PMID 18724359. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  16. ^ "Neuroblastoma in children : Cancerbackup". Retrieved 2008-01-01.
  17. ^ "Neuroblastoma: Pediatric Cancers: Merck Manual Professional". Retrieved 2008-01-01.
  18. ^ Miura K, Mineta H, Yokota N, Tsutsui Y (2001). "Olfactory neuroblastoma with epithelial and endocrine differentiation transformed into ganglioneuroma after chemoradiotherapy". Pathol. Int. 51 (12): 942–7. doi:10.1046/j.1440-1827.2001.01300.x. PMID 11844067.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  19. ^ "Althea Technologies Announces the Development of a Diagnostic Capable of Differentiating Multiple Forms of Childhood Cancer", press release, February 20, 2007
  20. ^ Strenger V, Kerbl R, Dornbusch HJ; et al. (2007). "Diagnostic and prognostic impact of urinary catecholamines in neuroblastoma patients". Pediatr Blood Cancer. 48 (5): 504–9. doi:10.1002/pbc.20888. PMID 16732582. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  21. ^ Pashankar F,O’Dorisio M, Menda Y (2005). "MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use". Journal of Nuclear Medicine. 46 (1 (suppl)): 55S–61S. PMID 15653652.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  22. ^ Peuchmaur M, d'Amore ES, Joshi VV; et al. (2003). "Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular". Cancer. 98 (10): 2274–81. doi:10.1002/cncr.11773. PMID 14601099. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  23. ^ a b "Neuroblastoma Treatment - National Cancer Institute". Retrieved 2008-07-30. Cite error: The named reference "titleNeuroblastoma Treatment - National Cancer Institute" was defined multiple times with different content (see the help page).
  24. ^ Brodeur GM, Seeger RC, Barrett A; et al. (1988). "International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma". J. Clin. Oncol. 6 (12): 1874–81. PMID 3199170. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  25. ^ Brodeur GM, Pritchard J, Berthold F; et al. (1993). "Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment". J. Clin. Oncol. 11 (8): 1466–77. PMID 8336186. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  26. ^ Schmidt ML, Lal A, Seeger RC, Maris JM, Shimada H, O'Leary M, Gerbing RB, Matthay KK (2005). "Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study". J Clin Oncol. 23 (27): 6474–80. doi:10.1200/JCO.2005.05.183. PMID 16116154.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  27. ^ Maris JM, Hogarty MD, Bagatell R, Cohn SL (2007). "Neuroblastoma". Lancet. 369 (9579): 2106–20. doi:10.1016/S0140-6736(07)60983-0. PMID 17586306.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  28. ^ Cohn SL, London WB, Monclair T, Matthay KK, Ambros PF, Pearson AD, for the INRG Working Group (2007). "Update on the development of the international neuroblastoma risk group (INRG) classification schema" (abstract). Journal of Clinical Oncology 2007 ASCO Annual Meeting Proceedings Part 1. 25 (18S).{{cite journal}}: CS1 maint: multiple names: authors list (link)
  29. ^ Janoueix-Lerosey I, Schleiermacher G, Michels E; et al. (2009). "Overall genomic pattern is a predictor of outcome in neuroblastoma". J. Clin. Oncol. 27 (7): 1026–33. doi:10.1200/JCO.2008.16.0630. PMID 19171713. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  30. ^ Michels, E; Vandesompele, J; Hoebeeck, J; Menten, B; De Preter, K; Laureys, G; Van Roy, N; Speleman, F. Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints. Cytogenet Genome Res. 2006;115:273–282. doi: 10.1159/000095924. [PubMed]
  31. ^ Carén H, Erichsen J, Olsson L, Enerbäck C, Sjöberg RM, Abrahamsson J, Kogner P, Martinsson T. High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene. BMC Genomics. 2008 Jul 29;9:353.
  32. ^ Woods WG, Gao RN, Shuster JJ; et al. (2002). "Screening of infants and mortality due to neuroblastoma". N. Engl. J. Med. 346 (14): 1041–6. doi:10.1056/NEJMoa012387. PMID 11932470. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  33. ^ Schilling FH, Spix C, Berthold F; et al. (2003). "Children may not benefit from neuroblastoma screening at 1 year of age. Updated results of the population based controlled trial in Germany". Cancer Lett. 197 (1–2): 19–28. doi:10.1016/S0304-3835(03)00077-6. PMID 12880955. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  34. ^ Tsubono Y, Hisamichi S (2004). "A halt to neuroblastoma screening in Japan". N. Engl. J. Med. 350 (19): 2010–1. doi:10.1056/NEJM200405063501922. PMID 15128908.
  35. ^ "Neuroblastoma Screening - National Cancer Institute". Retrieved 2008-07-30.
  36. ^ Darshak Sanghavi, "Screen Alert: How an Ounce of RX Prevention can Cause a Pound of Hurt", Slate magazine, November 28, 2006
  37. ^ Johnson E, Dean SM, Sondel PM (2007). "Antibody-based immunotherapy in high-risk neuroblastoma" (abstract). Expert Rev Mol Med. 9 (34): 1–21. doi:10.1017/S1462399407000518. PMID 18081947.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  38. ^ Neuroblastoma: biological insights into a clinical enigma. Brodeur GM. Nature Reviews Cancer. 2003 Mar;3(3):203-16. PMID 12612655
  39. ^ Schulte JH, Horn S, Otto T; et al. (2008). "MYCN regulates oncogenic MicroRNAs in neuroblastoma". Int. J. Cancer. 122 (3): 699–704. doi:10.1002/ijc.23153. PMID 17943719. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  40. ^ "Translating Neuroblastoma Genomics to the Clinic - J. Maris presentation ASCO 2007". Retrieved 2008-01-13.
  41. ^ Gisselsson D, Lundberg G, Ora I, Höglund M (2007). "Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas". J Carcinog. 6: 15. doi:10.1186/1477-3163-6-15. PMID 17897457.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  42. ^ Haase GM, Perez C, Atkinson JB (1999). "Current aspects of biology, risk assessment, and treatment of neuroblastoma". Semin Surg Oncol. 16 (2): 91–104. doi:10.1002/(SICI)1098-2388(199903)16:2<91::AID-SSU3>3.0.CO;2-1. PMID 9988866.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  43. ^ Fish JD, Grupp SA (2007). "Stem cell transplantation for neuroblastoma". Bone Marrow Transplant. 41: 159. doi:10.1038/sj.bmt.1705929. PMID 18037943.
  44. ^ Matthay KK, Villablanca JG, Seeger RC; et al. (1999). "Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group". N. Engl. J. Med. 341 (16): 1165–73. doi:10.1056/NEJM199910143411601. PMID 10519894. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  45. ^ "Neuroblastoma Treatment - National Cancer Institute". Retrieved 2008-07-30.
  46. ^ "Neuroblastoma Committee - Current Focus of Research". Retrieved 2008-01-13.
  47. ^ "A phase III trial of biologically-based therapy reduction for intermediate risk neuroblastoma. - ASCO". Retrieved 2008-01-13.
  48. ^ Pritchard J, Cotterill SJ, Germond SM, Imeson J, de Kraker J, Jones DR (2005). "High dose melphalan in the treatment of advanced neuroblastoma: results of a randomised trial (ENSG-1) by the European Neuroblastoma Study Group". Pediatr Blood Cancer. 44 (4): 348–57. doi:10.1002/pbc.20219. PMID 15546135.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  49. ^ Pearson AD, Pinkerton CR, Lewis IJ, Imeson J, Ellershaw C, Machin D (2008). "High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial". Lancet Oncol. 9 (3): 247–256. doi:10.1016/S1470-2045(08)70069-X. PMID 18308250.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  50. ^ Matthay KK, Villablanca JG, Seeger RC; et al. (1999). "Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group". N. Engl. J. Med. 341 (16): 1165–73. doi:10.1056/NEJM199910143411601. PMID 10519894. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  51. ^ Matthay KK, Reynolds CP, Seeger RC; et al. (2009). "Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study". J. Clin. Oncol. 27 (7): 1007–13. doi:10.1200/JCO.2007.13.8925. PMID 19171716. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  52. ^ Berthold F, Boos J, Burdach S; et al. (2005). "Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial". Lancet Oncol. 6 (9): 649–58. doi:10.1016/S1470-2045(05)70291-6. PMID 16129365. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  53. [[#cite_ref-titleClinical_Trials_(PDQ�)_-_National_Cancer_Institute_53-0|^]] [http://www.cancer.gov/templates/view_clinicaltrials.aspx?version=healthprofessional&cdrid=67429+ "Clinical Trials (PDQ�) - National Cancer Institute"]. Retrieved 2008-02-02. {{cite web}}: replacement character in |title= at position 21 (help)
  54. ^ "Autologous Stem Cell Transplantation for High-Risk Neuroblastoma" (PDF). Retrieved 2008-02-02.
  55. ^ "Response and toxicity to a dose-intensive multi-agent chemotherapy induction regimen for high risk neuroblastoma (HR-NB): A Children's Oncology Group (COG A3973) study. - ASCO". Retrieved 2008-02-02.
  56. ^ "Clinical Trials - National Cancer Institute". Retrieved 2008-02-02.
  57. ^ "Consolidation Treatment With Chimeric Anti-GD2-Antibody ch14.18 in Children Older Than 1 Year With Metastatic Neuroblastoma -- Simon et al. 22 (17): 3549 -- Journal of Clinical Oncology". Retrieved 2008-02-02.
  58. ^ "NCI Cancer Bulletin for May 19, 2009 - National Cancer Institute".
  59. ^ "Neuroblastoma Education Book" (PDF). Retrieved 2008-02-02.
  60. ^ [http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=69191&version=HealthProfessional&protocolsearchid=4015135 "Clinical Trials (PDQ�) - National Cancer Institute"]. Retrieved 2008-02-02. {{cite web}}: replacement character in |title= at position 21 (help)
  61. ^ "NB2004 - kinder krebs info . de". Retrieved 2008-02-02.
  62. ^ [http://www.cancer.gov/clinicaltrials/COG-ANBL0532 "Clinical Trials (PDQ�) - National Cancer Institute"]. Retrieved 2008-02-19. {{cite web}}: replacement character in |title= at position 21 (help)
  63. ^ George RE, Li S, Medeiros-Nancarrow C; et al. (2006). "High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update". J. Clin. Oncol. 24 (18): 2891–6. doi:10.1200/JCO.2006.05.6986. PMID 16782928. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  64. ^ "Texas Children's Cancer Center - Clinical Trials - PEPI: Protracted Etoposide In a Phase II Upfront Window for Induction Therapy for High Risk Neuroblastoma". Retrieved 2008-02-19.
  65. ^ "Neuroblastoma Protocol 2005: Therapy for Children with Advanced Stage High-Risk Neuroblastoma". Retrieved 2008-02-02.
  66. ^ "Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk Neuroblastoma - Full Text View - ClinicalTrials.gov".
  67. ^ "Sloan-Kettering - Neuroblastoma: Our Clinical Trials". Retrieved 2008-02-02.
  68. ^ Xue C, Haber M, Flemming C; et al. (2007). "p53 determines multidrug sensitivity of childhood neuroblastoma". Cancer Res. 67 (21): 10351–60. doi:10.1158/0008-5472.CAN-06-4345. PMID 17974978. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  69. ^ "Recurrent neuroblastoma: Randomized treatment with topotecan + cyclophosphamide (T+C) vs. topotecan alone(T). A POG/CCG Intergroup Study -- Frantz et al. 22 (14 Supplement): 8512 -- ASCO Meeting Abstracts". Retrieved 2008-03-13.
  70. ^ "Irinotecan Plus Temozolomide for Relapsed or Refractory Neuroblastoma -- Kushner et al. 24 (33): 5271 -- Journal of Clinical Oncology". Retrieved 2008-03-13.
  71. ^ "Phase I study of oral irinotecan and temozolomide in children with relapsed high-risk neuroblastoma: A New Approach to Neuroblastoma Therapy (NANT) Consortium study -- Wagner et al. 25 (18 Supplement): 9567 -- ASCO Meeting Abstracts". Retrieved 2008-03-13.
  72. ^ "DRAXIS Radiopharmaceutical Unit Approved to Run 2 Clinical Trials to Treat Neuroblastoma", DRAXIS Health Inc. press release, November 22, 2006
  73. ^ "Molecular Insight Pharmaceuticals, Inc. Initiates Phase 2a Azedra(TM) Clinical Trial in Neuroblastoma Patients".
  74. ^ "Molecular Insight Pharmaceuticals : Azedra Trials".
  75. ^ "Iodine I 131 Metaiodobenzylguanidine and a Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory High-Risk Neuroblastoma - Full Text View - ClinicalTrials.gov".
  76. ^ "NANT Home Page". Retrieved 2008-02-02.
  77. ^ "Painkiller Helps Against Child Cancer", medicalnewstoday.com, February 8, 2007, accessed March 8, 2007 (source apparently is a press release from the Karolinska Institutet in Sweden)
  78. ^ Ponthan F, Wickström M, Gleissman H; et al. (2007). "Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo". Clin. Cancer Res. 13 (3): 1036–44. doi:10.1158/1078-0432.CCR-06-1908. PMID 17289900. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  79. ^ Ceschel S, Casotto V, Valsecchi MG; et al. (2006). "Survival after relapse in children with solid tumors: a follow-up study from the Italian off-therapy registry". Pediatr Blood Cancer. 47 (5): 560–6. doi:10.1002/pbc.20726. PMID 16395684. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  80. ^ Gurney JG, Tersak JM, Ness KK, Landier W, Matthay KK, Schmidt ML (2007). "Hearing loss, quality of life, and academic problems in long-term neuroblastoma survivors: a report from the Children's Oncology Group". Pediatrics. 120 (5): e1229–36. doi:10.1542/peds.2007-0178. PMID 17974716.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  81. ^ Trahair TN, Vowels MR, Johnston K, Cohn RJ, Russell SJ, Neville KA, Carroll S, Marshall GM (2007). "Long-term outcomes in children with high-risk neuroblastoma treated with autologous stem cell transplantation". Bone Marrow Transplant. 40 (8): 741–6. doi:10.1038/sj.bmt.1705809. PMID 17724446.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  82. ^ "Childhood Cancer Survivors Face Increased Sarcoma Risk", HealthDay News, February 21, 2007
  83. ^ Oeffinger et al., "Chronic Health Conditions in Adult Survivors of Childhood Cancer", New England Journal of Medicine, October 12, 2006

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