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(R)-citramalate synthase

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(R)-citramalate synthase
Identifiers
EC no.2.3.1.182
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

(R)-citramalate synthase (EC 2.3.1.182, CimA) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + pyruvate + H2O CoA + (2R)-2-hydroxy-2-methylbutanedioate

This enzyme participates in a novel pyruvate pathway for isoleucine biosynthesis.

References

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  1. ^ Howell DM, Xu H, White RH (January 1999). "(R)-citramalate synthase in methanogenic archaea". Journal of Bacteriology. 181 (1): 331–3. PMC 103565. PMID 9864346.
  2. ^ Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G (August 2004). "Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway". Journal of Bacteriology. 186 (16): 5400–9. doi:10.1128/jb.186.16.5400-5409.2004. PMC 490871. PMID 15292141.
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