October 23: The Harvard women's hockey team took a 2-1 lead into the third period but allowed a goal for a 2-2 tie at Bright Hockey Center. McGill took advantage of a five-on-three situation early in the first period as Cathy Chartrand took a feed from Gillian Ferrari and beat Bellamy for an 1-0 lead. Harvard had several opportunities on the power play in the 17th minute, but could not score on McGill netminder Andrea Wickman. With less than a minute to play in the game, McGill pulled its goaltender. With an extra skater, Ann-Sophie Bettez and Leslie Oles almost scored. In the end, Katia Clement-Hydra converted from close range to tie the score at 2-2. The overtime stanza did not result in a game winning goal.
On September 18, 2010, Gillian Ferrari, a first-year Martlets player scored her first-ever CIS goal. It was on a 4-on-3 power play versus Wilfrid Laurier University.
On October 8, 2010, Leslie Oles, a first-year Martlets player scored once and added a pair of assists as the Martlets skated to a 7-4 win over Concordia Stingers in the season opener. The victory extended McGill's win streak to 82 consecutive games over QUHL opponents.
On February 10, 2011, Melodie Daoust signed a letter of intent to play for the McGill Martlets. She refused offers from numerous Canadian and American universities, including Cornell, Dartmouth and a full scholarship from Boston University.
December 31: Charline Labonte required only 13 saves to post her 59th career shutout as McGill defeated the nationally ranked fifth overall Alberta Pandas by a 3-0 mark in the final game of the Bisons Holiday Classic tournament at Max Bell Arena. In the game, the Martlets held a 31-13 edge in shots. Gillian Ferrari was credited with the game-winner on the power-play at 5:49 of the first period. Jasmine Sheehan, a fifth-year defender scored the second goal of the game. Logan Murray, a freshman from Calgary, scored the last goal of the contest.
McGill went into the six-team national tournament as the No. 1 seed for the fifth straight year after posting a 20-0 record to finish first in the Quebec conference for the sixth consecutive year and the seventh time in school history. Their CIS final opponents, StFX finished with a 29-1 record in league and playoff action and a silver-medal finish, the best result ever by an Atlantic conference team. The five Martlets goals were scored by Ann-Sophie Bettez, Jordanna Peroff, Caroline Hill, Jasmine Sheehan, and Alessandra Lind-Kenny.