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4-Aminoquinoline

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4-Aminoquinoline
Structural formula of 4-aminoquinoline
Space-filling model of the 4-aminoquinoline molecule
Names
IUPAC name
Quinolin-4-amine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.167.771 Edit this at Wikidata
UNII
  • InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11) checkY
    Key: FQYRLEXKXQRZDH-UHFFFAOYSA-N checkY
  • InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
  • n1ccc(c2ccccc12)N
Properties
C9H8N2
Molar mass 144.177 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline.

A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. Examples include amodiaquine, chloroquine, and hydroxychloroquine.[1]

References

  1. ^ Bray PG, Hawley SR, Ward SA (1996). "4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake". Mol. Pharmacol. 50 (6): 1551–8. PMID 8967977.