Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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4-HO-MPT, or 4-hydroxy-N-methyl-N-propyltryptamine, is a lesser-known psychedelic drug. It is part of the tryptamine class of psychoactive compounds and can be considered a derivative of the naturally occurring compound psilocin as well as being the 4-hydroxyl analog of MPT. 4-HO-MPT was first synthesized by Alexander Shulgin. In his book TiHKAL, the minimum dosage is listed as 10-20 mg, and the duration listed as 4–6 hours. The book describes 4-HO-MPT as producing visual distortion, vertigo, and slight insomnia.
Anecdotal reports on this substance vary greatly in detail, including any combination of visual distortion, sedation, stimulation, and dissociated thoughts. Some users report taking very large amounts via multiple routes of ingestion and feeling nothing. There are many possible explanations for this phenomenon, including placebo, fast tolerance-building, cross-tolerance with other compounds, differences between the salt and the freebase, differences in bio-availability between routes of ingestion, and an uncertainty of what users are actually ingesting.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. Additionally, this chemical may be considered illegal in the United States due to the Federal Analog Act. Extreme caution should be exercised by anyone planning on purchasing or ingesting this substance.
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