MS-245

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MS-245
MS-245 structure.png
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C19H22N2O3S
Molar mass 358.454 g/mol
3D model (Jmol)
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MS-245 is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor antagonist with a Ki of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT6 agonist EMDT.[1] It has been used as a lead compound for further development of tryptamine-derived 5-HT6 antagonists.[2][3] In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine.[4][5]

See also[edit]

References[edit]

  1. ^ Tsai Y, Dukat M, Slassi A, MacLean N, Demchyshyn L, Savage JE, Roth BL, Hufesein S, et al. (October 2000). "N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists". Bioorganic & Medicinal Chemistry Letters. 10 (20): 2295–9. doi:10.1016/S0960-894X(00)00453-4. PMID 11055342. 
  2. ^ Abate C, Kolanos R, Dukat M, Setola V, Roth BL, Glennon RA (August 2005). "Interaction of chiral MS-245 analogs at h5-HT6 receptors". Bioorganic & Medicinal Chemistry Letters. 15 (15): 3510–3. doi:10.1016/j.bmcl.2005.05.092. PMID 15990303. 
  3. ^ Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA (February 2008). "Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies". Journal of Medicinal Chemistry. 51 (3): 603–11. doi:10.1021/jm070910s. PMID 18201064. 
  4. ^ Pullagurla M, Bondareva T, Young R, Glennon RA (June 2004). "Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245". Pharmacology, Biochemistry, and Behavior. 78 (2): 263–8. doi:10.1016/j.pbb.2004.03.017. PMID 15219766. 
  5. ^ Young R, Bondareva T, Wesolowska A, Young S, Glennon RA (September 2006). "Effect of the 5-HT(6) serotonin antagonist MS-245 on the actions of (-)nicotine". Pharmacology, Biochemistry, and Behavior. 85 (1): 170–7. doi:10.1016/j.pbb.2006.07.029. PMID 16950502.