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Delta-beta thalassemia

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Delta-beta thalassemia
Delta-beta thalassemia
SpecialtyHematology Edit this on Wikidata
CausesProduces only gamma-globin and forms HbF(deletes entire delta and beta gene sequence)[1]
Diagnostic methodHigh-performance liquid chromatography
TreatmentBlood transfusions[2]

Delta-beta thalassemia is a rare form of thalassemia in which there is a reduced production of hemoglobin subunit delta and hemoglobin subunit beta and raised levels of hemoglobin subunit gamma. It is an autosomal recessive disorder.[1][3]

Signs and symptoms

An individual with delta-beta thalassemia is usually asymptomatic, however microcytosis can occur where the red blood cells are abnormally small.[1][4]

Mechanism

Structure of hemoglobin the proteins α and β subunits are in red and blue,

Delta-beta thalassemia is autosomal recessive disorder,[1] which means both parents are affected and two copies of the gene must be present.[5] A carrier gets a normal gene to produce hemoglobin A, from one parent and the other parent supplies a gene which makes no hemoglobin A.[6] Delta-beta thalassemia is considered rare.[2]

Delta-beta-thalassemia is caused by deletions of the entire delta and beta genes sequences and only gamma-globin and HbF are formed. Rarely, non-deletional forms have been reported.[7][8]

When two delta0 mutations are inherited, no hemoglobin A2 (alpha2, delta2) are formed. This is innocuous because only 2-3% of normal adult hemoglobin is hemoglobin A2. The individual will have normal hematological parameters (erythrocyte count, total hemoglobin, mean corpuscular volume).[medical citation needed] The delta-beta thalassemia demonstrates one mutation is at the +69 position.[9]

Relation to beta thalassemia

Delta-beta thalassemia can mask the diagnosis of beta thalassemia trait. In beta thalassemia, an increase in hemoglobin A2 results, but the co-existence of a delta-beta thalassemia mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia trait[10]

Diagnosis

Following the detection of hypochromic microcytic red blood cells, delta-beta thalassemia is confirmed by high-performance liquid chromatography.[11]

Treatment

When needed, treatment for anemia, such as blood transfusions are used.[2]

Stem cell transplant is another option, but the donor and the individual who will receive the bone marrow transplant must be compatible, the risks involved should be evaluated.[2][12][13]

See also

References

  1. ^ a b c d "Delta-beta-thalassemia". Orphanet. Retrieved 16 September 2016.
  2. ^ a b c d "Thalassaemia | Health | Patient". Patient. Retrieved 17 September 2016.
  3. ^ "HBD - hemoglobin subunit delta". Orphanet. Retrieved 17 September 2016.
  4. ^ Pal, G. K. & (2005). Textbook Of Practical Physiology - 2Nd Edn. Orient Blackswan. p. 53. ISBN 9788125029045. Retrieved 17 September 2016.
  5. ^ "Autosomal recessive: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 17 September 2016.
  6. ^ "Delta beta thalassemia carrier" (PDF). Public Health England. Archived from the original (PDF) on 24 September 2016. Retrieved 17 September 2016.
  7. ^ "Transcription and Translation - National Human Genome Research Institute (NHGRI)". www.genome.gov. NIH. Retrieved 17 September 2016.
  8. ^ Proytcheva, Maria, ed. (2010). Diagnostic pediatric hematopathology. Cambridge: Cambridge University Press. p. 61. ISBN 9780521881609. Retrieved 17 September 2016.
  9. ^ "OMIM Entry - * 142000 - HEMOGLOBIN--DELTA LOCUS; HBD". www.omim.org. Retrieved 17 September 2016.
  10. ^ Galanello, Renzo; Origa, Raffaella (2010). "Beta-thalassemia". Orphanet Journal of Rare Diseases. 5 (1): 11. doi:10.1186/1750-1172-5-11. ISSN 1750-1172. PMC 2893117. PMID 20492708.
  11. ^ Ahmad SQ, Zafar SI, Malik HS, Ahmed S (November 2017). "Delta-Beta Thalassaemia in a Pathan Family". Journal of the College of Physicians and Surgeons (Pakistan). 27 (11): 722–724. PMID 29132487.
  12. ^ Cao, Antonio; Galanello, Renzo (2010-02-01). "Beta-thalassemia". Genetics in Medicine. 12 (2): 61–76. doi:10.1097/GIM.0b013e3181cd68ed. ISSN 1098-3600. PMID 20098328.
  13. ^ "Risks". nhs.uk. Retrieved 2018-04-28.

Further reading

Scholia has a topic profile for Delta-beta thalassemia.
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