Kinin
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A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin.[1] They are members of the autacoid family.[2]
They act locally to induce vasodilation and contraction of smooth muscle.[3] Kinins function as mediators for inflammatory responses by triggering the immune system. They are also able to regulate cardiovascular and renal function through mediating the effects of ACE inhibitors.[4]
It is a component of the kinin-kallikrein system.
Their precursors are kininogens.[5]
In botany, the plant hormones known as cytokinins were first called kinins, but the name was changed to avoid confusion.[6]
Aspirin inhibits the activation of kallenogen by interfering with the formation of kallikrein enzyme which is essential in the process of activation.
References
- ^ Kinins. De Gruyter. 2011. ISBN 978-3-11-025235-4.
- ^ Kinins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ "Kinin" at Dorland's Medical Dictionary
- ^ Rhaleb NE, Yang XP, Carretero OA (April 2011). "The kallikrein-kinin system as a regulator of cardiovascular and renal function". Comprehensive Physiology. 1 (2): 971–93. doi:10.1002/cphy.c100053. PMC 4685708. PMID 23737209.
- ^ Online Medical Dictionary
- ^ Galuszka, Petr; Spíchal, Lukáš; Kopečný, David; Tarkowski, Petr; Frébortová, Jitka; Šebela, Marek; Frébort, Ivo (2008). "Metabolism of plant hormones cytokinins and their function in signaling, cell differentiation and plant development". Bioactive Natural Products (Part N). Studies in Natural Products Chemistry. Vol. 34. pp. 203–64. doi:10.1016/S1572-5995(08)80028-2. ISBN 978-0-444-53180-3.
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External links
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