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Symbols EFNA4 ; EFL4; EPLG4; LERK4
External IDs OMIM601380 MGI106643 HomoloGene3830 GeneCards: EFNA4 Gene
RNA expression pattern
PBB GE EFNA4 205107 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1945 13639
Ensembl ENSG00000243364 ENSMUSG00000028040
UniProt P52798 O08542
RefSeq (mRNA) NM_005227 NM_007910
RefSeq (protein) NP_005218 NP_031936
Location (UCSC) Chr 1:
155.06 – 155.07 Mb
Chr 3:
89.33 – 89.34 Mb
PubMed search [1] [2]

Ephrin-A4 is a protein that in humans is encoded by the EFNA4 gene.[1][2]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.[2]


  1. ^ Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976. 
  2. ^ a b "Entrez Gene: EFNA4 ephrin-A4". 

Further reading[edit]