Ephrin A4

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EFNA4
Identifiers
AliasesEFNA4, EFL4, EPLG4, LERK4, ephrin A4
External IDsMGI: 106643 HomoloGene: 3830 GeneCards: EFNA4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for EFNA4
Genomic location for EFNA4
Band1q21.3Start155,063,731 bp[1]
End155,069,553 bp[1]
RNA expression pattern
PBB GE EFNA4 205107 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182690
NM_005227
NM_182689

NM_007910

RefSeq (protein)

NP_005218
NP_872631
NP_872632

NP_031936

Location (UCSC)Chr 1: 155.06 – 155.07 MbChr 3: 89.33 – 89.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene.[5][6]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243364 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028040 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics. 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976. 
  6. ^ a b "Entrez Gene: EFNA4 ephrin-A4". 

Further reading[edit]