Dipraglurant

Dipraglurant
Clinical data
ATC code	None;
Identifiers
	IUPAC name 6-Fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]imidazo[1,2-a]pyridine;
CAS Number	872363-17-2;
PubChem CID	44557636;
ChemSpider	25069676;
UNII	CV8JZR21A1;
CompTox Dashboard (EPA)	DTXSID90236230 ;
Chemical and physical data
Formula	C16H12FN3
Molar mass	265.291 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1ccnc(c1)C#CCCc2cn3cc(ccc3n2)F;
	InChI InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2; Key:LZXMUJCJAWVHPZ-UHFFFAOYSA-N;

Dipraglurant (INN) (code name ADX-48621) is a negative allosteric modulator of the mGlu₅ receptor which is under development by Addex Therapeutics for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID).^[1]^[2]^[3] As of 2014, it is in phase II clinical trials for this indication.^[1] Addex Therapeutics is also investigating an extended-release formulation of dipraglurant for the treatment of non-parkinsonian dystonia.^[4]

References

^ ^a ^b Ana Martinez; Carmen Gil (29 July 2013). Emerging Drugs and Targets for Parkinson's Disease. Royal Society of Chemistry. pp. 255–. ISBN 978-1-84973-617-6.
^ John E. Macor (2012). Annual Reports in Medicinal Chemistry. Academic Press. pp. 83–. ISBN 978-0-12-396492-2.
^ Susan H. Fox; Jonathan M. Brotchie (8 October 2014). Levodopa-Induced Dyskinesia in Parkinson's Disease. Springer. pp. 323–. ISBN 978-1-4471-6503-3.
^ Addex Therapeutics. "Dipraglurant-ER for dystonia".

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