Metabotropic glutamate receptor 6

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GRM6
Identifiers
Aliases GRM6, CSNB1B, GPRC1F, MGLUR6, mGlu6, glutamate metabotropic receptor 6
External IDs MGI: 1351343 HomoloGene: 20232 GeneCards: GRM6
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GRM6
Genomic location for GRM6
Band 5q35.3 Start 178,978,327 bp[1]
End 178,996,206 bp[1]
RNA expression pattern
PBB GE GRM6 208035 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000843

NM_173372

RefSeq (protein)

NP_000834

NP_775548

Location (UCSC) Chr 5: 178.98 – 179 Mb Chr 5: 50.85 – 50.87 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutamate receptor, metabotropic 6, also known as GRM6, is a protein which in humans is encoded by the GRM6 gene.[5][6]

Function[edit]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113262 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000617 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: GRM6 glutamate receptor, metabotropic 6". 
  6. ^ Hashimoto T, Inazawa J, Okamoto N, Tagawa Y, Bessho Y, Honda Y, Nakanishi S (June 1997). "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6". Eur. J. Neurosci. 9 (6): 1226–35. PMID 9215706. doi:10.1111/j.1460-9568.1997.tb01477.x. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.