Metabotropic glutamate receptor 6

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Glutamate receptor, metabotropic 6
Symbols GRM6 ; CSNB1B; GPRC1F; MGLUR6; mGlu6
External IDs OMIM604096 HomoloGene20232 IUPHAR: 294 ChEMBL: 4573 GeneCards: GRM6 Gene
RNA expression pattern
PBB GE GRM6 208035 at tn.png
More reference expression data
Species Human Mouse
Entrez 2916 108072
Ensembl ENSG00000113262 ENSMUSG00000000617
UniProt O15303 Q5NCH9
RefSeq (mRNA) NM_000843 NM_173372
RefSeq (protein) NP_000834 NP_775548
Location (UCSC) Chr 5:
178.98 – 179 Mb
Chr 11:
50.85 – 50.87 Mb
PubMed search [1] [2]

Glutamate receptor, metabotropic 6, also known as GRM6, is a protein which in humans is encoded by the GRM6 gene.[1][2]


L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.[1]

See also[edit]


  1. ^ a b "Entrez Gene: GRM6 glutamate receptor, metabotropic 6". 
  2. ^ Hashimoto T, Inazawa J, Okamoto N, Tagawa Y, Bessho Y, Honda Y, Nakanishi S (June 1997). "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6". Eur. J. Neurosci. 9 (6): 1226–35. doi:10.1111/j.1460-9568.1997.tb01477.x. PMID 9215706. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.