Polidocanol

Polidocanol
Clinical data
Other names	Polydocanol; Laureth 9; Macrogol lauryl ether; Lauromacrogol; PEG-9 lauryl alcohol; POE-9 lauryl alcohol; Dodecylpolyethyleneglycolether; Hydroxyl polyethoxy dodecane; Oxypolyethoxydodecane;
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Topical: allowed; Injection: contraindication in months 1–3 and after week 36;
Routes of; administration	topical, subcutaneous injection
ATC code	C05BB02 (WHO) ;
Legal status
Legal status	OTC (topical), ℞ (injection);
Identifiers
	IUPAC name 3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-1-ol;
CAS Number	9002-92-0 ; 3055-99-0;
PubChem CID	656641;
ChemSpider	570993 ;
UNII	0AWH8BFG9A;
KEGG	D01993 ;
ChEMBL	ChEMBL1201751 ;
CompTox Dashboard (EPA)	DTXSID5039721 ;
ECHA InfoCard	100.019.351
Chemical and physical data
Formula	C30H62O10
Molar mass	582.816 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO;
	InChI InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3 ; Key:ONJQDTZCDSESIW-UHFFFAOYSA-N ;
	(what is this?) (verify)

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin.^[1] It is formed by the ethoxylation of dodecanol.

Sclerotherapy

Polidocanol is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol^[2] and Varithena.^[3] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.^[4]^[5]

References

^ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
^ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
^ "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Archived from the original (PDF) on 4 August 2016. Retrieved 1 October 2015.
^ Facts and Companies: Varicose Vein Treatment Approved
^ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

[1] "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.

[2] Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com

[3] "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Archived from the original (PDF) on 4 August 2016. Retrieved 1 October 2015.

[4] Facts and Companies: Varicose Vein Treatment Approved

[5] "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.

[1]

[2]

[3]

[4]

[5]