Polidocanol

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Polidocanol
Polidocanol skeletal.svg
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • Topical: allowed
    Injection: contraindication in months 1–3 and after week 36
Routes of
administration
topical, subcutaneous injection
ATC code
Legal status
Legal status
  • OTC (topical), (injection)
Identifiers
Synonyms

 

  • Polydocanol
  • Laureth 9
  • Macrogol lauryl ether
  • Lauromacrogol
  • PEG-9 lauryl alcohol
  • POE-9 lauryl alcohol
  • Dodecylpolyethyleneglycolether
  • Hydroxyl polyethoxy dodecane
  • Oxypolyethoxydodecane
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.105.513
Chemical and physical data
Formula C30H62O10
Molar mass 582.8073 g/mol (predicted)
3D model (Jmol)
 NYesY (what is this?)  (verify)

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin.[1] It is formed by the ethoxylation of dodecanol.

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol[2] and Varithena.[3] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.[4][5]

Pure polidocanol for pharmaceutical use

References[edit]

  1. ^ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12. 
  2. ^ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
  3. ^ "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Retrieved 1 October 2015. 
  4. ^ Facts and Companies: Varicose Vein Treatment Approved
  5. ^ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.